DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and grin3bb

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_017213803.2	Gene:	grin3bb / 100333101	ZFINID:	ZDB-GENE-131122-77	Length:	1114	Species:	Danio rerio

Alignment Length:	1029	Identity:	218/1029 - (21%)
Similarity:	386/1029 - (37%)	Gaps:	284/1029 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 YGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLIL---DTTKSGIASETVKSFTQALG 127
            |.||:.:.:.||...|.:.|...:|.....     |....:|   .|.:..:..|.:.||   |.
Zfish    82 YNLSLDVVAREAQSGDPESLFRCVCQDIVV-----QGVSAVLAFPQTQEEIVQMEFMSSF---LE 138

  Fly   128 LPTIS-ASYGQQGDLRQWRDLDEAKQKYLLQV---MPPADIIPEAIRSIVIHMNITNA-AIL--- 184
            :|.|| ..:|:.         .:.:.::.||:   :||:.:: |.:.:::.......: |:|
Zfish   139 IPFISIIEHGEP---------LKTQNRFHLQMTTRIPPSGLV-ELLLAVLQRSGWEESMAVLCHG 193

  Fly   185 YDDSFVMDHKYKSLLQNIQTR--------HVITAIAKDGKREREEQIEKLR----NLD------- 230
            ::|:.::|      |..:|.|        |:..|:.......|...|....    |||
Zfish   194 WEDAGLLD------LLKLQGRFGWGPSQWHLRAALNLSHSTARMANISDFLSEHFNLDHSPPASV 252

  Fly   231 -------------INNFFILG-TLQSIRMVL-ESVKPAYFERNFAWHAI-----TQNEGEISSQ- 274
                         :.:...|| ||.::..:: ..:.|.      |.|:|     ....||:..:
Zfish   253 LLFGADPECASSVLRSAHDLGLTLPTVHWIMGHPLSPD------ALHSIGLPLGLLAYGEVDHKP 311

  Fly   275 -----RDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGA 334
                 .|...::.....|.|..|..|.|::...|..::|..                .|:..||.
Zfish   312 LDFYISDALQLINRAVTAATVVRPDLALIQNMVNCFDKPNK----------------HELPSSGQ 360

  Fly   335 WPKDMEYLNCDDFQGGNTP---QRNLDLRDYFTKITEPTSYGTF------DLVTQSTQPFNGHSF 390
            :  ...:|:...|.|...|   ||||.        ...||:...      |.|.|.|....| |:
Zfish   361 Y--IARFLSNTSFVGLTGPVIVQRNLS--------RVHTSHKVHIWSLRRDAVGQPTWVTVG-SW 414

  Fly   391 MKFEMDINVLQIRGGSSVNSKSIG-------KWISGL---NSELIVKDEEQMKNLTADTVYRIFT 445
            ....:::....:..|||...::.|       :|.:|.   .|.|                 |:.|
Zfish   415 EGGRLNVEEQGLWQGSSPRQRTEGQMGREGRRWRAGFPVSGSRL-----------------RVVT 462

  Fly   446 VVQAPFIM-----RDETAPKG--------------------------------YK----GYCIDL 469
            :|:.||:.     .|...|.|                                |.    ||||||
Zfish   463 LVEHPFVFTREVDEDGNCPAGQYCLDAGTNSSETLDHLYAERAQGNKSFLPPDYSKCCYGYCIDL 527

  Fly   470 INEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVP 534
            :.:::..::|::.:..|.|||:|.: :.|||.|:|..|:...||:.:.|.|:.:.|..|||||.|
Zfish   528 LEKLSEDMNFEFDLYIVGDGKYGAV-KGGQWTGLVGDLLSGVADMAVTSFSINSARSKVIDFTSP 591

  Fly   535 YYDL-VGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYS---YQNNR 595
            ::.. :||.:..:..::|  :..|:..|..::|:.|..|...|:..:.:::..||:.   :..||
Zfish   592 FFSTSLGILVRSKDTAAP--IGAFMWPLHWSMWMGIFVALHITALFLTLYEWKSPFGMTPHGRNR 654

  Fly   596 EKYKDDEEKREFNLKECLWFCMTSLTPQG-GGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAF 659
            .|.        |:....|..|...|..:. ..:.||..:||.:...|.:|..::::||||||||.
Zfish   655 VKV--------FSYSSALNLCYAILFGRTVSSKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAV 711

  Fly   660 LTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERS 724
            :...:....|..:.| ||    |:.|..|.       |...:.:...|
Zfish   712 MVGEKTFEEVSGIHD-AK----LHHPSQGF-------RFGTVRESSAE----------------- 747

  Fly   725 KLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRY-LQL-TNCD 787
                 || :...:.:|.:.|::...|.|.| .||.::....... ||:.|...:.| :.: .:|.
Zfish   748 -----DY-MKKSFPEMHEYMRKFNEPTTPD-GVATLKTDPPQLD-AFIMDKALLDYEVSIDADCK 804

  Fly   788 LQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDK---PED 849
            |..||:.|:.:.|.|.:.|.|.|....:..:....:...::.|.:||:|    :..|.|   ...
Zfish   805 LLTVGKPFAIEGYGIGLPQNSPLTSNISEFVSRYKSDGYMDMLHDKWYK----VVPCGKRVFAVT 865

  Fly   850 QSDGISIQNIGGVFIVIFVGIGMACITLV------------------FEYWWYRYRKNPRIIDVA 896
            ::..:.|::..|:|:::.||:..|.:||.                  |:||.:..:|..|.:::.
Zfish   866 ETLQMGIRHFSGLFVLLCVGVTGALLTLAGEHAFYRLVLPHIRRKQKFKYWLHTSQKIHRALNMT 930

  Fly   897 -------EANAERS----NAADHPGKLVDGVILGHSGE-KFEKSKAALRPRFNQ 938
                   .||.|:|    .|..||..  ....||.... ..|.:|.|..|:.|:
Zfish   931 YEDVKRQRANTEKSCNIQKAQPHPPP--QPAPLGSFARWNNESAKVAQEPKDNK 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	83/434 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	105/445 (24%)
		Lig_chan	565..870	CDD:278489	69/313 (22%)
grin3bb	XP_017213803.2	PBP1_iGluR_NMDA_NR3	29..428	CDD:107372	75/402 (19%)
grin3bb	XP_017213803.2	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	105/459 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591835
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840