Protein Alignment Ir25a and gria1

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_004912781.1
• Gene: gria1 / 100127569
• XenbaseID: XB-GENE-995621
• Length: 903
• Species: Xenopus tropicalis
• Alignment Length: 1000
• Identity: 249/1000 - (24%)
• Similarity: 432/1000 - (43%)
• Gaps: 255/1000 - (25%)

  Fly    36 INVLFINEVDNEPAAKAVEVVLTYLKKNIRYGLS---------VQLDSIEANKSDAKVLLEAICN 91
            |..||.|:...|.||             .|:.||         .|:|.:  |.||:..:....|:
 Frog    27 IGGLFPNQQSQEHAA-------------FRFALSQLSEPPKLLPQIDIV--NISDSFEMTYTFCS 76

  Fly    92 KYATSI------EKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEA 150
            :::..:      ..::|.:::             .||..||.:..|:.|:..           ..
 Frog    77 QFSKGVYAIFGFYDRKTVNML-------------TSFCGALHVCFITPSFPV-----------AT 117

  Fly   151 KQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDG 215
            ..:::||:.|.   :.:|:.|::.:........:||..     :..|:||.:          .|.
 Frog   118 SNQFVLQLRPE---LQDALISVIEYYKWKKFVYIYDAD-----RGLSVLQKV----------LDT 164

  Fly   216 KREREEQIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATI 280
            ..|:..|:..:.       .:..|.:..|::.:                     ::...:|...:
 Frog   165 AAEKNWQVTAVN-------ILTTTEEGYRLLFQ---------------------DLDKSKDRQIV 201

  Fly   281 MFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTI--KEMLQSGAWPKDMEYLN 343
            :..:       .:||..:.|...:..|..: ..:::.||...|:.|  ::..::||.....:.:|
 Frog   202 IDCE-------SERLNAILTQVVVKLEKNI-IGYHYILANLGFMDIDMQKFKEAGANVTGFQLVN 258

  Fly   344 CDDFQGGNTPQ--RNLDLR-----DYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQ 401
            ..|.......|  :|.|.|     |:  |..:.||..|:|.|....:.|  .|..|..:||:
 Frog   259 YTDTMVSRIMQQWKNYDGREQPRVDW--KKPKYTSALTYDGVRVMAEAF--QSLRKQRIDIS--- 316

  Fly   402 IRG--GSSVNSKSIGKW--------------ISGLNSELIVKDEEQMKNLTA------------- 437
            .||  |..:.:.:: .|              :.||:..:...::.:..|.|.
 Frog   317 RRGNAGDCLANPAV-PWGQGIDIQRALQQVRLEGLSGNVQFNEKGRRTNYTLHVLELKHEGIRHI 380

  Fly   438 --------------------DTV------YRIFTVVQAPFIMRDETAPK-----GYKGYCIDLIN 471
                                ||:      |.:.|:::||::|..:.|.:     .::|||::|..
 Frog   381 AHWNEDDKLIPLATDAQAGNDTIGVQNRTYIVTTILEAPYVMLKKNADQLEGNDRFEGYCVELAA 445

  Fly   472 EIAAIVHFDYTIQEVEDGKFGNMDENGQ-WNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPY 535
            |||..|.|.|.::.|:|||:|..|.:.: |||:|.:|:..:||:.:..:::...||.||||:.|:
 Frog   446 EIAKHVGFKYKLEIVKDGKYGARDSDMKAWNGMVGELVYGRADLAVAPLTITLVREEVIDFSKPF 510

  Fly   536 YDLVGITIMMQRP-SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYK 599
            ..| ||:||:::| .|...:|.||..|...:|:||:.||...|.::::..|:|||.:.|  |:::
 Frog   511 MSL-GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHN--EEFE 572

  Fly   600 DDEEK------REFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAA 658
            :.:|:      .||.:...|||.:.:...||...:|::||||:|...||.|..|||:||||||||
 Frog   573 EGKEQPTTDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAA 637

  Fly   659 FLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVER 723
            ||||.|:.:|:||.||||||.:|.|..|:..|...:|                          :|
 Frog   638 FLTVERMVSPIESADDLAKQTEIAYGTLDSGSTKEFF--------------------------KR 676

  Fly   724 SKLAVWDYPVSDKYTKMWQAMQEAKLPA----TLDEAVARVRNSTAATGFAFLGDATDIRYL-QL 783
            ||:||::        |||..|:.|: |:    |.:|.:.|||.|...  :|:|.::|...|: |.
 Frog   677 SKIAVFE--------KMWTYMRSAE-PSVFVKTTEEGMNRVRKSKGK--YAYLLESTMNEYIEQR 730

  Fly   784 TNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWW-KNDEALAKCDKP 847
            ..||...||.....|.|.||..:||.|:...|.|:|.|..:..|:|||.||| ...|..:|....
 Frog   731 KPCDTMKVGGNLDSKGYGIATPKGSPLRGAVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGS 795

  Fly   848 EDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRII-------------DVAEAN 899
            :|::..:|:.|:.|||.::..|:|:|.:..:.|: .|:.|...:.:             .|..|.
 Frog   796 KDKTSALSLSNVAGVFYILIGGLGLAMLVALIEF-CYKSRSESKKMKGFCLIPQTTVTETVRMAT 859

  Fly   900 AERSNAADHPGKLVDGVILGHSGEK 924
            ..|.:.|...|:  :|.::.|...|
 Frog   860 LPRPSTAGGSGE--NGRVVSHDFPK 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	70/420 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	152/422 (36%)
gria1	XP_004912781.1	PBP1_iGluR_AMPA_GluR1	26..393	CDD:380613	75/466 (16%)
		PBP2_iGluR_AMPA_GluR1	407..788	CDD:270447	150/420 (36%)