DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and gria4

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_031751480.1	Gene:	gria4 / 100125052	XenbaseID:	XB-GENE-5838893	Length:	902	Species:	Xenopus tropicalis

Alignment Length:	983	Identity:	274/983 - (27%)
Similarity:	441/983 - (44%)	Gaps:	220/983 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKN---IRYGLSVQL 72
            :|:..||..|...     |..::..|..|||...|.|..|..:.:.|.....|   ..:.|...:
Frog     9 VLFFSGFWGLAMG-----AFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNESEALFNLVPHV 68

  Fly    73 DSIEANKSDAKVLLEAICNKYATSI------EKKQTPHLILDTTKSGIASETVKSFTQALGLPTI 131
            |:||.:.|.|  :..|.|::|:..:      ..|::.|             |:.||..||.:..|
Frog    69 DNIETSNSFA--VTNAFCSQYSRGVFAIFGLYDKRSVH-------------TLTSFCSALHISLI 118

  Fly   132 SASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYK 196
            :.|:..:|:           .:::||:.|.   :..|:.|::.|....:...|||    .|..|
Frog   119 TPSFPTEGE-----------SQFVLQLRPS---LRGALLSLLDHYGWNHYVFLYD----TDRGY- 164

  Fly   197 SLLQNI-----QTRHVITAIA-------------KDGKREREE------QIEKLRNLDINNFFIL 237
            |:||.|     |....::||.             :|..|.:|.      ::|:|:|:
Frog   165 SILQAIMEKAGQNGWQVSAICVENFNDASYRRLLEDLDRRQENKFVIDCEVERLQNI-------- 221

  Fly   238 GTLQSIRMVLESVKPAYFERNFAWHAITQNEG--EISSQR-----DNAT----IMFMKPMAYTQY 291
              |:.|..|.:.||        .:|.|..|.|  :||..|     .|.|    :.|..|:. |:.
Frog   222 --LEQIVSVGKHVK--------GYHYIIANLGFKDISLDRFMHGGANVTGFQLVDFNTPIV-TEL 275

  Fly   292 RDRLGLL-RTTYNLNEE-PQLSSAFYFDLAL---RSFLTIK-------------EMLQSGAWP-- 336
            ..|...| :..|..:|. |:.:||..:|..|   .:|..::             :.|.:.|.|
Frog   276 MQRWKTLDQREYPGSESPPKYTSALTYDGVLVMAEAFRILRRQKIDLSRRGNAGDCLANPAAPWG 340

  Fly   337 --KDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINV 399
              .|||              |.|..    .:|...|....||           |...:....::|
Frog   341 QGIDME--------------RTLKQ----VRIQGLTGNIQFD-----------HYGRRVNYTMDV 376

  Fly   400 LQIRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTADTVYR---IFTVVQAPFIM--RDETAP 459
            |:::   |...:.||.| :.::..::::.|...||.::....|   :.|:::||::|  ::....
Frog   377 LELK---SNGLRKIGYW-NDMDKLVLLQHEPAFKNDSSGIENRTVIVTTILEAPYVMYKKNHELL 437

  Fly   460 KG---YKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQWNGIVKKLMDKQADIGLGSMS 520
            :|   ::|||:||..|||..:...|.|..|.|||:|..| |...|||:|.:|:..:|:|.:..::
Frog   438 EGNDKFEGYCVDLAYEIAKHIGIKYKIAIVPDGKYGARDSETKIWNGMVGELVYGKAEIAVAPLT 502

  Fly   521 VMAEREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFD 584
            :...||.||||:.|:..| ||:||:::| .|...:|.||..|...:|:||:.||...|.::::..
Frog   503 ITLVREEVIDFSKPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS 566

  Fly   585 RWSPYSYQNNR-EKYKD---DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFG 645
            |:|||.:.... |..|:   |:...||.:...|||.:.:...||...:|::||||:|...||.|.
Frog   567 RFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFT 631

  Fly   646 FIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWK 710
            .|||:||||||||||||.|:.:|:||.:|||||.:|.|..|:..|...:|
Frog   632 LIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFF--------------- 681

  Fly   711 DLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAK---LPATLDEAVARVRNSTAATGFAFL 772
                       :|||:||        |.|||..|:.|:   ...|..|.|||||.|...  ||||
Frog   682 -----------KRSKIAV--------YEKMWTYMKSAEPSVFTKTTAEGVARVRKSKGK--FAFL 725

  Fly   773 GDATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWK 836
            .::|...|: |...||...||.....|.|.:|..:.|.|::..|.|:|.|..:..|:|||.|||.
Frog   726 LESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKHSQLRNAVNLAVLKLNEQGLLDKLKNKWWY 790

  Fly   837 NDEALAKCDK----PEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAE 897
            :.   .:|..    .:|::..:|:.|:.|||.::..|:|:|.:..:.|: .|:.|...:.:.:..
Frog   791 DK---GECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEF-CYKSRAEAKRMKLTF 851

  Fly   898 ANAERSNA 905
            :.|.|:.|
Frog   852 SEAIRNKA 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	96/451 (21%)
		PBP2_iGluR_putative	438..836	CDD:270435	151/415 (36%)
		Lig_chan	565..870	CDD:278489	111/316 (35%)
gria4	XP_031751480.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	98/457 (21%)
gria4	XP_031751480.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	152/420 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100