Protein Alignment Ir25a and gria4

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_031751480.1
• Gene: gria4 / 100125052
• XenbaseID: XB-GENE-5838893
• Length: 902
• Species: Xenopus tropicalis
• Alignment Length: 983
• Identity: 274/983 - (27%)
• Similarity: 441/983 - (44%)
• Gaps: 220/983 - (22%)

  Fly    11 ILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKN---IRYGLSVQL 72
            :|:..||..|...     |..::..|..|||...|.|..|..:.:.|.....|   ..:.|...:
 Frog     9 VLFFSGFWGLAMG-----AFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNESEALFNLVPHV 68

  Fly    73 DSIEANKSDAKVLLEAICNKYATSI------EKKQTPHLILDTTKSGIASETVKSFTQALGLPTI 131
            |:||.:.|.|  :..|.|::|:..:      ..|::.|             |:.||..||.:..|
 Frog    69 DNIETSNSFA--VTNAFCSQYSRGVFAIFGLYDKRSVH-------------TLTSFCSALHISLI 118

  Fly   132 SASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYK 196
            :.|:..:|:           .:::||:.|.   :..|:.|::.|....:...|||    .|..|
 Frog   119 TPSFPTEGE-----------SQFVLQLRPS---LRGALLSLLDHYGWNHYVFLYD----TDRGY- 164

  Fly   197 SLLQNI-----QTRHVITAIA-------------KDGKREREE------QIEKLRNLDINNFFIL 237
            |:||.|     |....::||.             :|..|.:|.      ::|:|:|:
 Frog   165 SILQAIMEKAGQNGWQVSAICVENFNDASYRRLLEDLDRRQENKFVIDCEVERLQNI-------- 221

  Fly   238 GTLQSIRMVLESVKPAYFERNFAWHAITQNEG--EISSQR-----DNAT----IMFMKPMAYTQY 291
              |:.|..|.:.||        .:|.|..|.|  :||..|     .|.|    :.|..|:. |:.
 Frog   222 --LEQIVSVGKHVK--------GYHYIIANLGFKDISLDRFMHGGANVTGFQLVDFNTPIV-TEL 275

  Fly   292 RDRLGLL-RTTYNLNEE-PQLSSAFYFDLAL---RSFLTIK-------------EMLQSGAWP-- 336
            ..|...| :..|..:|. |:.:||..:|..|   .:|..::             :.|.:.|.|
 Frog   276 MQRWKTLDQREYPGSESPPKYTSALTYDGVLVMAEAFRILRRQKIDLSRRGNAGDCLANPAAPWG 340

  Fly   337 --KDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINV 399
              .|||              |.|..    .:|...|....||           |...:....::|
 Frog   341 QGIDME--------------RTLKQ----VRIQGLTGNIQFD-----------HYGRRVNYTMDV 376

  Fly   400 LQIRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTADTVYR---IFTVVQAPFIM--RDETAP 459
            |:::   |...:.||.| :.::..::::.|...||.::....|   :.|:::||::|  ::....
 Frog   377 LELK---SNGLRKIGYW-NDMDKLVLLQHEPAFKNDSSGIENRTVIVTTILEAPYVMYKKNHELL 437

  Fly   460 KG---YKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQWNGIVKKLMDKQADIGLGSMS 520
            :|   ::|||:||..|||..:...|.|..|.|||:|..| |...|||:|.:|:..:|:|.:..::
 Frog   438 EGNDKFEGYCVDLAYEIAKHIGIKYKIAIVPDGKYGARDSETKIWNGMVGELVYGKAEIAVAPLT 502

  Fly   521 VMAEREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFD 584
            :...||.||||:.|:..| ||:||:::| .|...:|.||..|...:|:||:.||...|.::::..
 Frog   503 ITLVREEVIDFSKPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS 566

  Fly   585 RWSPYSYQNNR-EKYKD---DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFG 645
            |:|||.:.... |..|:   |:...||.:...|||.:.:...||...:|::||||:|...||.|.
 Frog   567 RFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFT 631

  Fly   646 FIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWK 710
            .|||:||||||||||||.|:.:|:||.:|||||.:|.|..|:..|...:|
 Frog   632 LIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFF--------------- 681

  Fly   711 DLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAK---LPATLDEAVARVRNSTAATGFAFL 772
                       :|||:||        |.|||..|:.|:   ...|..|.|||||.|...  ||||
 Frog   682 -----------KRSKIAV--------YEKMWTYMKSAEPSVFTKTTAEGVARVRKSKGK--FAFL 725

  Fly   773 GDATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWK 836
            .::|...|: |...||...||.....|.|.:|..:.|.|::..|.|:|.|..:..|:|||.|||.
 Frog   726 LESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKHSQLRNAVNLAVLKLNEQGLLDKLKNKWWY 790

  Fly   837 NDEALAKCDK----PEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAE 897
            :.   .:|..    .:|::..:|:.|:.|||.::..|:|:|.:..:.|: .|:.|...:.:.:..
 Frog   791 DK---GECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEF-CYKSRAEAKRMKLTF 851

  Fly   898 ANAERSNA 905
            :.|.|:.|
 Frog   852 SEAIRNKA 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	97/446 (22%)
		PBP2_iGluR_putative	438..836	CDD:270435	151/415 (36%)
gria4	XP_031751480.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	98/457 (21%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	152/420 (36%)