Protein Alignment Ir25a and grin2ca

DIOPT Version :9

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 1023
• Identity: 211/1023 - (20%)
• Similarity: 375/1023 - (36%)
• Gaps: 307/1023 - (30%)

  Fly     9 SKILWLLGFLSLLSSFSLEIA-------AQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKN-IR 65
            |..|| |..|.|||..|:...       .:.|.|:.|:|      ..:|...|:.....::| :.
Zfish     9 SDTLW-LPVLLLLSVCSVPCCQCRPFGMVEPTVNVAVVF------SGSAYQTEIKGRLSRENFLD 66

  Fly    66 YGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSF-----TQA 125
            ..|.|...::..|.::.:.||..||:..|.:     ..|.::  .:..|.||.|...     ||.
Zfish    67 LPLEVNPITVLVNNTNPRTLLTRICDTLAAN-----RVHGVV--FEDNIGSEAVAQILDFISTQT 124

  Fly   126 LGLPTISASYG------QQGD-----------LRQWRDLDEAKQKY-------LLQVMPPADIIP 166
             .:|.:..|.|      .:||           .:|...:.:..::|       :..:.|..|...
Zfish   125 -AVPIVGISGGSAVVLPHKGDGSTFLQLGSSIEQQINGMFKVMEEYNWDSFVVVTSLYPGYDTYV 188

  Fly   167 EAIRSIVIHMNITNAAILYDDSFVM-----------------DHKYKSLLQNIQTRHVITAIAKD 214
            :.|||.:            |.|:.:                 |.:.:.|||.|..:.::...:.|
Zfish   189 DYIRSFI------------DTSYFLWELQDTLTFDMSADGMNDLRARRLLQQIDAQVLLVYCSHD 241

  Fly   215 GKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNAT 279
                 |.|.                |.|:...:..|.|.|
Zfish   242 -----EAQY----------------LFSMAREVGLVGPGY------------------------- 260

  Fly   280 IMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLT------IKEMLQSGAWPKD 338
            |.|:..:|       :|          .|.::....|.:.|.|.:|      ::..::.|.   .
Zfish   261 IWFIPSLA-------VG----------NPNIAPPDSFPVGLISIITDRWKMSLRNRVRDGV---A 305

  Fly   339 MEYLNCDDF--QGGNTPQRNLDLRDYFTKITEPTSYGT-----FDLVTQSTQ-PFNGHSFMKFEM 395
            :.....:.|  |.|..|..::|.    .....|.|.||     .::..::|. .||...::....
Zfish   306 IVVKGVESFRKQRGFIPDGHMDC----LSPIRPASNGTLYRHMLNVSWENTDFSFNSDGYLVNPS 366

  Fly   396 DINVLQIRGGSSVNSKSIGKWISGL---------NSELIVKDEEQMKNLTADTVYRIFTVVQAPF 451
            .|.:...||.   ....:|.:.||:         .....::.....::||      :.|:.:.||
Zfish   367 MIIITLDRGR---QWDKVGNYESGILQMRYPVWPRYGTFLEPVSDNRHLT------VATLEERPF 422

  Fly   452 IMRDETAP--------------------------KGY-----KGYCIDLINEIAAIVHFDYTIQE 485
            ::.:...|                          :.|     ||:|||::.:::..:.|.|.:..
Zfish   423 VIVEAVDPVTGTCLSNTVPCRRQSNKTETIVGHTEPYTKLCCKGFCIDILKKLSRNIKFSYDLYL 487

  Fly   486 VEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSS 550
            |.:||.|.: ..|.|||::.::..|:||:.:||:::..||..:|||:||:.: .||::|:.|.:.
Zfish   488 VTNGKHGKL-VRGIWNGMIGEVFYKRADMAIGSLTINEERSEIIDFSVPFVE-TGISVMVARSNG 550

  Fly   551 PSSLFKFLTVLETNVW-----LCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLK 610
            ..|...||......||     :|:..    .:..:::|:..||..|..:....||.... .|.:.
Zfish   551 TVSPSAFLEPYSPAVWVMMFVMCLTV----VAVTVFVFEYCSPVGYNRSLVSAKDPGGP-TFTIG 610

  Fly   611 ECLW----FCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVES 671
            :.:|    ....:..|.   |.||..:.:::...|..|..|.:||||||||||:...:....|..
Zfish   611 KSVWLLWGIVFNNSVPI---ENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSG 672

  Fly   672 LDDLAKQY---KILYAPL------NGSSAMTYFER--MSNIEQMFYEI--WKDLSLNDSLTAVER 723
            |.|  |::   :..|.|.      |||:     ||  .||..:|...:  :....:.|:|.:::.
Zfish   673 LSD--KKFQKPQDQYPPFRFGTVPNGST-----ERNIRSNYPEMHSHMVKYNQKGVEDALNSLKT 730

  Fly   724 SKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYL--QLTNC 786
            .||.                                          ||:.||..:.|:  :...|
Zfish   731 GKLD------------------------------------------AFIYDAAVLNYMAGKDEGC 753

  Fly   787 DLQVV--GEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPED 849
            .|..:  |:.|:...|.||:|:.|..|...:.|:|..|.....:||:..|.   ..:.:.:|.|.
Zfish   754 KLVTIGSGKVFATTGYGIALQKESRWKRPIDLALLQFLADGDTQKLQTVWL---TGICRNEKKEV 815

  Fly   850 QSDGISIQNIGGVFIVIFVGIGMACITLVFE---YWWYRY--RKNPRI 892
            .|..:.|.|:.|||.::.|.:|::.:...:|   ||..|:  ||:.|:
Zfish   816 MSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYWKLRHSVRKSERL 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	74/455 (16%)
		PBP2_iGluR_putative	438..836	CDD:270435	106/454 (23%)
		Lig_chan	565..870	CDD:278489	76/330 (23%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..398	CDD:107373	77/458 (17%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	108/468 (23%)
		NMDAR2_C	847..>938	CDD:313729	6/17 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830