DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and Dqx1

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_291084.1	Gene:	Dqx1 / 93838	MGIID:	2136388	Length:	718	Species:	Mus musculus

Alignment Length:	659	Identity:	192/659 - (29%)
Similarity:	324/659 - (49%)	Gaps:	45/659 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LMEQRERLPIRQYRDQILYCLEKHQ--VVILVGETGSGKSTQVPQYLYEW----GWHTKGLIGIT 98
            |:|||..|||...|...|..||...  ||::.|:.|||||||:||:..|:    |:.| |.:.:|
Mouse    35 LLEQRRALPIWAARFLFLEHLESSPTGVVLVSGDPGSGKSTQIPQWCAEFALARGFQT-GQVTVT 98

  Fly    99 EPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGV 163
            :|..::.::||:|||.|....:|..:||.:...:.....|.::|..:.:.|:||.:......:.|
Mouse    99 QPYPLAAMSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSV 163

  Fly   164 IIVDEAHERNMLTDMILGLLKKI-LRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEG 227
            :|:|||.||::.:|::.|||:.. ||.......::  ...|.:...:|.::.|:..: |::..|.
Mouse   164 LILDEAQERSVASDLLQGLLRDTRLRNLPGDPRVV--VVTDPALEPKFQAFWGNSPI-VRVPREP 225

  Fly   228 RMHPVSNFYLNEPCADYVKETVETVWKL-HQKEPPGDILAFLTGQEEVLEALDLLREYIASSEQE 291
            ...|...:....| .|.|:...:.|.:| .|:|.|||:|.:|..:||:....:.|     |.|..
Mouse   226 GGDPTLAYKDTVP-TDLVEAACQAVLELCQQEEAPGDVLVYLPSEEEISLCCESL-----SGEMG 284

  Fly   292 NL-------KVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVK 349
            .|       :|||::...:...| :|:.......||:|:...:|:.|.::|.|.:|||.|.....
Mouse   285 TLAVPGPPPRVLPLHPGCAQAIQ-TVYEDTDVSVRKIVVTHWLADFSFSLPSIQHVIDSGLELRS 348

  Fly   350 WYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQP-PEMRRSELSGA 413
            .|||:..::|.|:.|:||..|..|..||....||...|||:||..|..||..| |::....||..
Mouse   349 VYNPRIRAESQVLRPISKCQAEARLLRAKGFPPGSCLRLYSKSTLELEAPPLPHPKVCEENLSSL 413

  Fly   414 ILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKM 478
            :|.|....|.......|...|..:.|:.|||.|..|.|:::.|.|: .:|.:|:|.|....|:|.
Mouse   414 VLLLMRKQIAEPGECHFLDRPAPEALMRALEDLDYLAALNDDGELS-DLGVILSEFPLPPELAKA 477

  Fly   479 LYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAEGDFITMLNAYTGFVEE 543
            |..|.:..|.:|::|:.|:|.....|:||..:..:.:.|   |..|.|:||..:::..|..||:.
Mouse   478 LLASCEFNCVDEMLTLAAMLTAAPGFTRPPLSAGEAALR---RALEHADGDHSSLIQVYEAFVQS 539

  Fly   544 GMTKEFCGQYFLIYRNLKRAHSLREQLITVARK---KYGIPIFSCKGDVEKLCKCITAGFFTQVA 605
            |..:.:|....|.:.:|.:|..||.:|:.:.::   ....|.|..:.:...|.|.:.:|:|.:||
Mouse   540 GADEAWCQARGLNWESLCQARKLRAELVELMQRIELPLSQPAFGSEQNRRDLQKALLSGYFLKVA 604

  Fly   606 --------YLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYGELLQTTKLFMNYVTVIKREW 662
                    ||..:  ::.::..:....:.|......|.. :|:|.....:....:..|:.|:.|.
Mouse   605 RDTDGTGNYLLLT--HKHVAQLSPYCSYRNRRTPAQPPT-WVLYHSFSISKDNCLCIVSEIQPEM 666

  Fly   663 LTELAPHYY 671
            |.||||.|:
Mouse   667 LVELAPPYF 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	189/654 (29%)
		DEXDc	64..202	CDD:238005	45/144 (31%)
		HELICc	289..380	CDD:197757	30/97 (31%)
		HA2	448..534	CDD:214852	26/85 (31%)
		OB_NTP_bind	<581..670	CDD:285018	22/96 (23%)
Dqx1	NP_291084.1	HrpA	9..672	CDD:224557	189/654 (29%)
		DEAQ box	167..170		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820