Protein Alignment CG3225 and DHX57

DIOPT Version :10

• Sequence 1: NP_608860.1
• Gene: CG3225 / 33680
• FlyBaseID: FBgn0031631
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_945314.1
• Gene: DHX57 / 90957
• HGNCID: 20086
• Length: 1386
• Species: Homo sapiens
• Alignment Length: 786
• Identity: 225/786 - (28%)
• Similarity: 355/786 - (45%)
• Gaps: 189/786 - (24%)

  Fly    40 LMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGLIG-------- 96
            ::::|:.||..:.|:.||..|.|||||::.|.||.||:||:||::.:     ..|.|
Human   537 ILQERQSLPAWEERETILNLLRKHQVVVISGMTGCGKTTQIPQFILD-----DSLNGPPEKVANI 596

  Fly    97 -ITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQ 160
             .|:|||:|.:::|.|||:||.|.||.||||.:|.....||.|::.:.|.|:|||.:..|..|..
Human   597 ICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQG 661

  Fly   161 YGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFF-SWPGSGEVSVKLS 224
            ...|||||.|||...:|.:|.:||.|:.:|..|::|:.|||::|..||::| |.|       .::
Human   662 VSHIIVDEVHERTEESDFLLLVLKDIVSQRPGLQVILMSATLNAELFSDYFNSCP-------VIT 719

  Fly   225 IEGRMHPVSNFYLNEPCA----------------------------------------------- 242
            |.||..||..|:|.:..|
Human   720 IPGRTFPVDQFFLEDAIAVTRYVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLSLHLQ 784

  Fly   243 -------------------------------------DYVKETVETV-----WKLHQKE--PPGD 263
                                                 |:.|..:|.:     |.:..|.  |||.
Human   785 DQDSVKDAVPDQQLDFKQLLARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYPPGA 849

  Fly   264 ILAFLTGQEEVLEALDLLREYIASSEQENLK------VLPMYGSMSSTDQLSVFFTPPKGTRKVV 322
            ||.||.|..|:    .:|.|.:.|:...|.:      :.|::.|:||.:|.:||..||.|..|::
Human   850 ILVFLPGLAEI----KMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKII 910

  Fly   323 LATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYR 387
            ::||||||||||..:|||||.|.:|.|.|:.....:||....||:|:|:||.|||||:..|..:.
Human   911 ISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFH 975

  Fly   388 LYTKSDY-EALAPRQPPEMRRSELSGAILQLKALGI--GNILRFDFP---SPPPAQNLLSALESL 446
            |:|...| ..|..:|.||::|..|....|::|.|.:  .:.|:..|.   .||...:|.::...|
Human   976 LFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSVFSRLIEPPHTDSLRASKIRL 1040

  Fly   447 FALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAV 511
            ..|.|:.....|| |:||.||.||....:.|::.......|.:..:||.|.|..:|.|..|....
Human  1041 RDLGALTPDERLT-PLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKK 1104

  Fly   512 AQQSGRIAHRK---FEVAEGDFITMLNAYTGF---VEEGM--TKEFCGQYFLIYRNLKRAHSLRE 568
            .:     |::|   |..|..|::.:|.||.|:   .:||:  :..:|.|.||..|.|:...||:.
Human  1105 EE-----ANQKKLEFAFANSDYLALLQAYKGWQLSTKEGVRASYNYCRQNFLSGRVLQEMASLKR 1164

  Fly   569 QLITV-----------------ARKKYGIPIFSCKGD--------VEKLCKCITAGFFTQVAYLH 608
            |...:                 .|.:.|..:....|:        .:.:...:.|..:..|..:.
Human  1165 QFTELLSDIGFAREGLRAREIEKRAQGGDGVLDATGEEANSNAENPKLISAMLCAALYPNVVQVK 1229

  Fly   609 H-SGVYRQISSG--------TELA----------IHPNSTLYTLP--QAQYVVYGELLQTTKLFM 652
            . .|.:::.|:|        .||.          |||:|..|.:.  .:.|::|.|.::|:::|:
Human  1230 SPEGKFQKTSTGAVRMQPKSAELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFI 1294

  Fly   653 NYVTVI 658
            ...:::
Human  1295 RDCSMV 1300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	38..>669	CDD:441249	225/786 (29%)
DHX57	NP_945314.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..106
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..147
		UBA_DHX57	181..218	CDD:270502
		RWD_DHX57	242..425	CDD:467661
		zf_CCCH_4	305..323	CDD:465719
		HrpA	543..>1170	CDD:441249	204/648 (31%)
		DEVH box	668..671		2/2 (100%)
		OB_NTP_bind	1213..1310	CDD:400182	17/88 (19%)