DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and dhx33

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001093527.3	Gene:	dhx33 / 796505	ZFINID:	ZDB-GENE-131127-77	Length:	680	Species:	Danio rerio

Alignment Length:	686	Identity:	275/686 - (40%)
Similarity:	408/686 - (59%)	Gaps:	54/686 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KPKFLKPETDDAITDSAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILV 69
            ||..|.|....|..                    |:..||..|||.|.|.|::..|.:....:.:
Zfish    25 KPGMLLPRAGHAAA--------------------GVEAQRRHLPIYQSRTQVISQLRQLHSAVFI 69

  Fly    70 GETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESM 134
            |||||||:||:||||||.|...:|:|.||:||||:.::||.|||:|:...:|..|||.|||.:..
Zfish    70 GETGSGKTTQIPQYLYEAGIGRQGIIAITQPRRVAAISLAGRVAEEKKVQLGKLVGYTVRFEDVT 134

  Fly   135 SSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSS-----LK 194
            |..||:||||:|:||||.:.||||.:|.|:|:||||||.:.||::.|::|...|:|..     ||
Zfish   135 SPETKLKFMTDGMLLREAIGDPLLLRYTVVILDEAHERTVHTDVLFGVVKAAQRRRLEQNKIPLK 199

  Fly   195 LIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQKE 259
            :::.|||:|...||::|:      .|..|.:|||.||:..:|..:|.:||::..:.:::::||:.
Zfish   200 VVVMSATMDVDLFSQYFN------KSPVLYLEGRQHPIQIYYTKQPQSDYLQAALVSIFQIHQEA 258

  Fly   260 PPG-DILAFLTGQEEVLEAL-----DLLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGT 318
            |.. |||.|||||||: |||     |:.:....:|  .::.|:|:|.|:....|:.||...|||:
Zfish   259 PSSHDILVFLTGQEEI-EALARTCRDISKHLPDTS--GSMTVVPLYASLPPAQQMRVFLPAPKGS 320

  Fly   319 RKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPG 383
            |||:|:||||||||||.||.||||.|.||.|.:||.:..:.|.:..||||.|.||||||||...|
Zfish   321 RKVILSTNIAETSITISGIKYVIDTGMVKAKRFNPDSGLEVLAVQRVSKAQAWQRAGRAGREDAG 385

  Fly   384 KVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFA 448
            ..|||||:.::|.||....||::|..|:..:|||.|||:.::|.|||.|.|..:::.:|:|.|..
Zfish   386 SCYRLYTEDEFENLANMTVPEIQRCNLASVVLQLLALGVPDVLNFDFVSKPSPESMRTAVEQLCI 450

  Fly   449 LDAIDEQG---NLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASA 510
            |.|:|.:.   :|| |:|..:|..|.....||.|.:|....|:|||:|||:||.|.|:...|.
Zfish   451 LGAVDRKDDHVSLT-PLGKKMACFPLEPRFSKTLLISPDFSCTEEILTIISLLSVDSVLYNPP-- 512

  Fly   511 VAQQSGRIA-HRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVA 574
             |::...|: .:||..:|||.||:||.|..|.:....|::|.:.|:..||:.....:|.||..:.
Zfish   513 -ARRDEVISVRKKFISSEGDHITLLNIYRAFKKVSGNKDWCRENFVNSRNMGLVGEVRAQLRDIC 576

  Fly   575 RKKYGIPIFSCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQ-- 637
             .|..:.:.|...|:..:.:|:..|.|...|.|...|.|..:.:...::|||:|.|:   ||:
Zfish   577 -IKMNLKLESSVCDLANVRRCLAHGLFMSAAELQPDGSYVALDTHQPVSIHPSSVLF---QARPV 637

  Fly   638 YVVYGELLQTTKLFMNYVTVIKREWLTELAPHYYQQ 673
            .|::.|||.|::.:|..:.:|:.:||.|.||.|:::
Zfish   638 CVLFNELLHTSRCYMRDLCLIQTDWLHEAAPEYFRR 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	266/644 (41%)
		DEXDc	64..202	CDD:238005	72/142 (51%)
		HELICc	289..380	CDD:197757	49/90 (54%)
		HA2	448..534	CDD:214852	34/89 (38%)
		OB_NTP_bind	<581..670	CDD:285018	28/90 (31%)
dhx33	NP_001093527.3	DEXDc	50..234	CDD:214692	88/189 (47%)
		DEXDc	64..207	CDD:238005	72/142 (51%)
		Helicase_C	264..381	CDD:278689	62/119 (52%)
		HA2	451..536	CDD:214852	34/88 (39%)
		OB_NTP_bind	570..670	CDD:285018	31/103 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	193	1.000	Domainoid score	I3157
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.730