DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and dqx1

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001072743.1	Gene:	dqx1 / 780200	XenbaseID:	XB-GENE-5919961	Length:	714	Species:	Xenopus tropicalis

Alignment Length:	686	Identity:	198/686 - (28%)
Similarity:	347/686 - (50%)	Gaps:	52/686 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DDAITDSAGGEQQSSAF---VFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSG 75
            :|...:..||:.:.:.|   .|:..: ..|:.:|..|||...:.|.|..|:...:|::.|..|.|
Frog     3 EDGQEEEDGGDLELNPFDGLPFSSRY-YHLLSERHLLPIWDMKAQFLERLQSSNIVLVCGAPGCG 66

  Fly    76 KSTQVPQYLYEWGWHTK---GLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSC 137
            |||||||:..|:....:   |.|.:::|...:..:||.|||.|....:|..|.:.:...:.....
Frog    67 KSTQVPQWCAEFALSQRFSCGSIMVSQPHPTAAFSLALRVADEMDLNLGHEVAFSLPQEDCTGPS 131

  Fly   138 TKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKL-IISSAT 201
            |.::|..:.:||:|:.::|||...|::::|||..|::.:|::|||||.:..:|...:| :::|..
Frog   132 TILRFSWDSLLLQEMTSNPLLESAGIVVLDEADARSVASDLLLGLLKDVHVQRPEFRLVVVTSPQ 196

  Fly   202 IDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCA-DYVKETVETVWKLHQKEPPGDIL 265
            ::|...|..      ||.:..|.:. ...||.......|.: |.|......|..:|::..|||:|
Frog   197 LEAPLLSFL------GEEASVLRVP-HTAPVCEVVYRPPVSPDCVLAVSHMVLDIHRRGDPGDVL 254

  Fly   266 AFLTGQEEVLE-ALDLLREYIASSEQENLKVLPMYGSM-------SSTDQLSVFFTPPKG----T 318
            .||..:||..: ::.||        .|:|.:.|..|::       ||..::...:...:|    .
Frog   255 VFLASEEEAYQCSVSLL--------TESLSLSPSLGNLVPFTLLESSGSEVQCVYEALQGHCGTQ 311

  Fly   319 RKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPG 383
            |:|.|:.:::|.|.::|.|.||||.|..:...|||:..:|..|..|||||:|..|..|| :....
Frog   312 RRVFLSQSLSELSFSLPNIRYVIDTGAEQQNMYNPRIRADFQVRRPVSKATAEIRRLRA-QATDS 375

  Fly   384 KVYRLYTKSDYEALAPR-QPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLF 447
            ..||||:::.|::..|. .||.:.:..||..:|.:|.|.|.::.:.||...|..::|:.|||.|.
Frog   376 VCYRLYSETVYQSQMPDFSPPRILQENLSRLVLLMKRLDIADMGQCDFLDRPAPESLMQALEDLD 440

  Fly   448 ALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQV--QSIFSRPASA 510
            .|.|:|:.|||:: ||.:::|:|....:||.:..|.:..|..|::|:.|:|.|  :.....|.:|
Frog   441 YLAALDDDGNLSE-VGIIMSEIPLDPQISKSILASCEFHCVSEMLTLAAMLSVVPRCFLPGPHTA 504

  Fly   511 VAQQSGRIAHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVAR 575
            ...:|    .::.:|.|||.:|::|.|..:.|.  .:|:|.:..|..|.|::|..||.:|:.:.:
Frog   505 EVLES----RQELQVPEGDHMTLINIYEKYKES--DEEWCSRCALCPRALQQAERLRAELLELLQ 563

  Fly   576 K---KYGIPIFSCKGDVEKLCKCITAGFFTQVAY-LHHSGVYRQISSGTELAIHPNSTLY-TLPQ 635
            :   ....|.|..:.:...:.:.:.:|.|.:||. :...|.|..::......:||.|..| ..|.
Frog   564 RIELPVSPPNFLSQENTLNIRRSLISGGFLKVARDVDGQGNYLMLTHKHVANLHPFSVYYGCCPP 628

  Fly   636 AQYVVYGELLQTTKLFMNYVTVIKREWLTELAPHYY 671
            ..:|:|.:...:....::..|.|..|.|.|.||.||
Frog   629 PAWVLYHDFTISQDNCISIATEILPEMLVEFAPQYY 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	189/652 (29%)
		DEXDc	64..202	CDD:238005	45/141 (32%)
		HELICc	289..380	CDD:197757	33/101 (33%)
		HA2	448..534	CDD:214852	27/87 (31%)
		OB_NTP_bind	<581..670	CDD:285018	22/90 (24%)
dqx1	NP_001072743.1	HrpA	17..>533	CDD:224557	161/537 (30%)
dqx1	NP_001072743.1	OB_NTP_bind	<570..663	CDD:311586	22/92 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000