DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3225 and dhx35

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001072515.1	Gene:	dhx35 / 779970	XenbaseID:	XB-GENE-5868299	Length:	701	Species:	Xenopus tropicalis

Alignment Length:	683	Identity:	325/683 - (47%)
Similarity:	465/683 - (68%)	Gaps:	18/683 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KFLKPETDD---AITDSAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVIL 68
            :|.||.|:.   .|.:......:.|:.::|.:.::.:..||::||:.:.|:.|||.:|.:|.|::
Frog     9 RFWKPGTEGPGATIAEERQSNFEVSSVIYNPHASLSIEHQRQKLPVFKLRNHILYLVENYQTVVI 73

  Fly    69 VGETGSGKSTQVPQYLYEWGWHTKG-LIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLE 132
            :||||.|||||:||||.|.||..:| ::|:|:||||:.|::|.|||:|||.::|..|||.:||.:
Frog    74 IGETGCGKSTQIPQYLTEAGWTAEGRVVGVTQPRRVAAVSVAGRVAEERGAVLGHEVGYCIRFDD 138

  Fly   133 SMS-SCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLI 196
            ... ..|:|||:|:|:|:||:::|||||:|.|:::||||||.:.||:.:|||||:.:||..|:|:
Frog   139 CTDPQATRIKFLTDGMLVREMMSDPLLTRYSVLMLDEAHERTLYTDIAIGLLKKVQKKRGDLRLV 203

  Fly   197 ISSATIDASFFSEFFSWPGSGEVS----VKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQ 257
            ::|||:||..|..||:...:.:.|    ..|::|||..||..||...|..||:|.||:||.|:||
Frog   204 VASATLDAEKFKAFFNQNDTNDPSRDTCAILTVEGRTFPVDIFYTQSPVPDYLKSTVQTVMKIHQ 268

  Fly   258 KEPPGDILAFLTGQEEVLEALDLLREYI----ASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGT 318
            .:..|||||||||||||...:.:|.|..    .|..:::|:|||||..:.:::|:.||.......
Frog   269 SDLEGDILAFLTGQEEVESVVSMLVEQARILSRSGMKKHLRVLPMYAGLPTSEQMKVFERVSHSA 333

  Fly   319 RKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPG 383
            ||||:||||||.||||.||.:|||||:||::.|:||...:|||:||||:|||.|||||:||.|.|
Frog   334 RKVVVATNIAEASITINGISFVIDCGFVKLRAYDPKRAVESLVVVPVSQASANQRAGRSGRNRSG 398

  Fly   384 KVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFA 448
            :.|||||:.|:..|.|...|||:||.|:..|||||||||.|:|||.|.||||||:::.|||.|:|
Frog   399 QCYRLYTEEDFLKLPPSTVPEMQRSNLAPVILQLKALGIDNVLRFHFLSPPPAQSMVQALELLYA 463

  Fly   449 LDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQ 513
            |..:|:...||:|:|..:||.|.:.|.:|||..||..|||.||::|.|::|:|:||..|.:   |
Frog   464 LGGLDKHCRLTEPLGVRMAEFPLNPMFAKMLLESGNFGCSAEILSIAAMMQIQNIFVVPPN---Q 525

  Fly   514 QSGRI-AHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKK 577
            :|..| .||||.|.|||.:||||.:..|::...:..:|.|.||.|:.|.||.::||||..:. .|
Frog   526 KSQAIREHRKFAVEEGDHLTMLNVFEAFIKFNKSSHWCQQRFLNYKGLMRAVTVREQLKKLL-SK 589

  Fly   578 YGIPIFSCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYG 642
            :.:|..|.:||.:.:.:||.:|||...|.||.:||||.:..|.||.|||.|.||......:|::.
Frog   590 FKVPKNSSEGDPDPILRCIVSGFFANAAKLHSTGVYRTVRDGHELYIHPTSVLYAEKPPNWVLFS 654

  Fly   643 ELLQTTKLFMNYVTVIKREWLTELAPHYYQQTT 675
            |::||.|.:|..||.::..||.|||||:|||.|
Frog   655 EVVQTNKYYMRDVTAVESAWLLELAPHFYQQGT 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	311/638 (49%)
		DEXDc	64..202	CDD:238005	74/139 (53%)
		HELICc	289..380	CDD:197757	51/90 (57%)
		HA2	448..534	CDD:214852	40/86 (47%)
		OB_NTP_bind	<581..670	CDD:285018	39/88 (44%)
dhx35	NP_001072515.1	HrpA	7..701	CDD:224557	325/683 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8429
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6406
Inparanoid	1	1.050	626	1.000	Inparanoid score	I847
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189127at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto105047
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160