DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and dhx38

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_002937626.2	Gene:	dhx38 / 734019	XenbaseID:	XB-GENE-990308	Length:	1212	Species:	Xenopus tropicalis

Alignment Length:	677	Identity:	272/677 - (40%)
Similarity:	406/677 - (59%)	Gaps:	31/677 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KPETDDAITDSAGGE----------QQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQ 64
            ||..:|...|....:          :.||.|    :....|||||:.|||...:.::|..:..:.
Frog   474 KPIAEDGAVDYKAEQKFADHMRERSEASSDF----SRKKSLMEQRQYLPIFAVQQELLTIIRDNS 534

  Fly    65 VVILVGETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVR 129
            :||:||||||||:||:.|||:|.|:...|:|..|:||||:.:::|.||::|....:|:.|||.:|
Frog   535 IVIVVGETGSGKTTQLTQYLHEDGYTDYGMIACTQPRRVAAMSVAKRVSEEMQVSLGEEVGYAIR 599

  Fly   130 FLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLK 194
            |.:..|..|.||:||:||||||.|.:..|..|..:|:||||||::.||::.|||::::.:||.||
Frog   600 FEDCTSEKTLIKYMTDGILLRECLREADLDHYSAVIMDEAHERSLNTDVLFGLLREVVTRRSDLK 664

  Fly   195 LIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQKE 259
            ||::|||:||..|:.||     |.|.: ..|.||..||...:...|..|||:..|:...::|...
Frog   665 LIVTSATMDADKFATFF-----GNVPI-FYIPGRTFPVDILFSKTPQEDYVEAAVKQALQIHLSG 723

  Fly   260 PPGDILAFLTGQEEVLEALDLLREYIASSEQ-ENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVL 323
            ..||||.|:.|||::....|.:.|.:...:. ..|.|||:|..:.|..|..:|...|.|.||.::
Frog   724 AAGDILIFMPGQEDIEVTSDQIVERLEELDSAPPLAVLPIYSQLPSDLQAKIFQKAPDGVRKCIV 788

  Fly   324 ATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRL 388
            ||||||||:|:.||::|||.||.|:|.:||:...|:|.|.|:|:|:|.||:|||||..||:.|||
Frog   789 ATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCYRL 853

  Fly   389 YTKSDYE-ALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAI 452
            ||:|.|: .|.....||::|:.||..:|.||:||:.::|.|.|..|||..|:|:::..|:.|.|:
Frog   854 YTQSAYKNELLHTTVPEIQRTNLSNVVLLLKSLGVQDLLLFHFMDPPPEDNMLNSMYQLWILGAL 918

  Fly   453 DEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGR 517
            |..|.|| |.|.|:.|.|....|||||.||..||||.||:.::::|.|.:||.||... .::|.:
Frog   919 DNTGALT-PTGRLMVEFPLDPALSKMLIVSCDMGCSSEILIVVSMLSVPAIFYRPKGR-EEESDQ 981

  Fly   518 IAHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQL--ITVARKKYGI 580
            : ..||.|.|.|.:|.||.:..:.....:..:|.|:|:..:.:::...:|.||  |.|:::   :
Frog   982 V-REKFAVPESDHLTYLNVFLQWKNNNYSSGWCNQHFIHAKAMRKVREVRAQLKDIMVSQR---M 1042

  Fly   581 PIFSCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQA-QYVVYGEL 644
            .:.||..|.:.:.|||.|.:|.|.|.|...|.|..:.:|....:||.|:|:.:... .|:||.||
Frog  1043 SLSSCGSDWDIVRKCICAAYFHQAARLKGIGEYVNVRTGMPCHLHPTSSLFGMGYTPDYIVYHEL 1107

  Fly   645 LQTTKLFMNYVTVIKREWLTELAPHYY 671
            :.|||.:|..||.:..|||.||.|.:|
Frog  1108 VMTTKEYMQCVTAVDGEWLAELGPMFY 1134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	263/632 (42%)
		DEXDc	64..202	CDD:238005	69/137 (50%)
		HELICc	289..380	CDD:197757	45/91 (49%)
		HA2	448..534	CDD:214852	37/85 (44%)
		OB_NTP_bind	<581..670	CDD:285018	35/89 (39%)
dhx38	XP_002937626.2	HrpA	483..1131	CDD:224557	267/663 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920