DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and dhx40

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001184155.2	Gene:	dhx40 / 733877	XenbaseID:	XB-GENE-995801	Length:	744	Species:	Xenopus tropicalis

Alignment Length:	656	Identity:	244/656 - (37%)
Similarity:	382/656 - (58%)	Gaps:	44/656 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVSTVTLANR 111
            |||.:::.:::.....:..:|::|:|||||:||:|||||:.|:...|:||:|:||||:|:::|.|
Frog    21 LPIHRWKGELVKAATDNPFLIVMGDTGSGKTTQLPQYLYKAGFGKNGMIGVTQPRRVATISVAQR 85

  Fly   112 VAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLT 176
            ||:|....:|.||||.|||.:..|..|.||:||:|.|||..||||.||:|..|::||||||::.|
Frog    86 VAEEMNCSLGSTVGYQVRFDDCTSERTVIKYMTDGCLLRNTLADPDLTKYSTIVLDEAHERSLST 150

  Fly   177 DMILGLLKK------ILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNF 235
            |::.|||||      ..|::..||:|:.|||:::...|.||     |...| ::|.|::.|:...
Frog   151 DILFGLLKKQFQLRSFKRRKYPLKVIVMSATLESQKLSSFF-----GNCPV-VTIPGKVFPIKER 209

  Fly   236 YLN------EPCADYVKETVETVWKLHQKEPPGDILAFLTGQEEVLEALDLL---------REYI 285
            :||      :....||.|||:...:.|..||.||||.|||||.|:..|.:||         |..:
Frog   210 FLNLIGPRDKDSTAYVTETVKITLQTHLNEPEGDILVFLTGQAEIERACNLLFKKAEGIDYRHDV 274

  Fly   286 ASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKW 350
            .....|.|.:||:||||.:..|..:|..||.|.||.||:||||.||:||.||.||||.|:||...
Frog   275 YDRSVEGLLILPLYGSMPTDQQKRIFVPPPSGIRKCVLSTNIAATSVTIEGIRYVIDSGFVKQLN 339

  Fly   351 YNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAP-RQPPEMRRSELSGAI 414
            |||:...|.|.|||:||:.|:||||||||..|||.:|:|::..::...| ...|:::|:.|:..|
Frog   340 YNPRAGLDILEIVPISKSEAVQRAGRAGRTAPGKCFRIYSEEFWDKCMPDHMIPDIKRTSLASVI 404

  Fly   415 LQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKML 479
            |.||.|.|.:::||.:...|..:::|.||:.|:...|||..|.:|| :|:.:.|.|.|..|:..:
Frog   405 LTLKCLDIHDVIRFPYLDQPEERHILEALKKLYQCSAIDRTGCVTK-LGHFIIEFPLSPNLACAV 468

  Fly   480 YVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAEG---DFITMLNAYTGFV 541
            ..:...||.:.::.:.|:|.|:.:|.:...:..|:...:.|.:.....|   ||.|:|..:....
Frog   469 IKATSFGCEDLLLPVAAMLSVEHVFIQSGQSQKQKEAGLGHEELSQLAGGCNDFATLLYIFEQCK 533

  Fly   542 EEGMTKEFCGQYFLIYRNLKRAHSLREQLITVA---RKKYGIPIFSCKGD-VEKLCKCITAGFFT 602
            .......:|.:..:.:|.||.|.::.:||..:.   ::....|:....|. .|.|.:|:.||:|:
Frog   534 ASPKPASWCHENGIHWRALKSALNVEKQLKEITNRLKQNKDFPVEKFDGPRNEMLRRCLCAGYFS 598

  Fly   603 QVAYLHHSGVYRQISS----GTELAIHPNSTLY-TLPQAQYVVYGELLQTTKLFMNYVTVIKREW 662
            .||   ...|.|...:    |:.:.|||:|.|: ...:.:::::..:|.|:|:|:..|..|:.||
Frog   599 NVA---RRSVGRTFCTMDGHGSMIHIHPSSALFGKESELEWILFHNVLVTSKIFVRTVCPIRYEW 660

  Fly   663 LTELAP 668
            :.:|.|
Frog   661 VKDLLP 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	243/654 (37%)
		DEXDc	64..202	CDD:238005	74/143 (52%)
		HELICc	289..380	CDD:197757	52/90 (58%)
		HA2	448..534	CDD:214852	23/88 (26%)
		OB_NTP_bind	<581..670	CDD:285018	28/94 (30%)
dhx40	NP_001184155.2	HrpA	1..700	CDD:224557	244/656 (37%)
		DEXDc	40..182	CDD:238005	74/141 (52%)
		HELICc	281..368	CDD:197757	50/86 (58%)
		HA2	441..526	CDD:214852	23/85 (27%)
		OB_NTP_bind	560..668	CDD:285018	30/110 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010