DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and dhx9

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_002937403.1	Gene:	dhx9 / 733723	XenbaseID:	XB-GENE-967775	Length:	1257	Species:	Xenopus tropicalis

Alignment Length:	740	Identity:	210/740 - (28%)
Similarity:	331/740 - (44%)	Gaps:	144/740 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGL----IGITEPRRVS 104
            ||.||::::.::|::.:....|||:.|.||.||:||||||:.:........    |.:|:|||:|
Frog   387 RESLPVKKFEEEIMHAVHNSPVVIIRGATGCGKTTQVPQYILDECIRNDRAAQCNIVVTQPRRIS 451

  Fly   105 TVTLANRVAQERGELVGDTVGYVVRFLESM--SSCTKIKFMTEGILLREVLADPLLTQYGV---- 163
            .|::|.|||.||||.:|.:.||.||| ||:  .....:.|.|.|:|||::.|       |:
Frog   452 AVSVAERVAFERGEEIGKSCGYSVRF-ESVLPRPHASMLFCTVGVLLRKLEA-------GIRGIS 508

  Fly   164 -IIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSE-FFSWPGSGEVSVKLSIE 226
             :||||.|||::.||.:|.:|:.:::....:::|:.|||||.|.|.| ||:.|       .:.:.
Frog   509 HVIVDEIHERDINTDFLLVVLRDVIQAFPDIRVILMSATIDTSMFCEYFFNCP-------IIEVF 566

  Fly   227 GRMHPVSNFYLNEPCA-----------------------------------DYVKETVETVWKLH 256
            ||..||..::| |.|.                                   ||..||..::.:|.
Frog   567 GRTFPVQEYFL-EDCIQMTQFIPPPRDKKKKDKDEEGGDDEETNCNLVCGDDYGPETRRSMSQLS 630

  Fly   257 QKEP-----------------PGDILAFLTGQEEVLEALDLLREYIASSEQENLKVLPMYGSMSS 304
            :||.                 ||.:|.||.|. .::.|:....|........:..:||::..:..
Frog   631 EKETPLELIEALLKYIETLNVPGAVLVFLPGW-NLIYAMQKHLEMNPHFGSHSYCILPLHSQIPR 694

  Fly   305 TDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKAS 369
            .:|..||...|.|..||:|:||||||||||..:|||||....|||.:.......:...|..||.:
Frog   695 DEQRKVFDPVPDGIIKVILSTNIAETSITINDVVYVIDSCKQKVKLFTSHNNMTNYATVWASKTN 759

  Fly   370 AIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRF--DFPS 432
            ..||.|||||:|||..:.|.:::.:|.|.....||:.|:.|....|.:|.|.:|.|.:|  ....
Frog   760 LEQRKGRAGRVRPGFCFHLCSRARFERLETHLTPEIFRTPLHEVALSIKLLRLGGIGQFLSKAIE 824

  Fly   433 PPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIAL 497
            |||...::.|..:|..|||:|....|| |:|.:||:||....|.||:.    |||...:...:..
Frog   825 PPPLDAVIEAEHTLRELDALDSNDELT-PLGRILAKLPIEPRLGKMMI----MGCIFYVGDALCT 884

  Fly   498 LQVQSIFSRPASAVAQQSGRIAHRKFEVAE-GDFITMLNAYTGFVEEGMTKE-----FCGQYFLI 556
            :...:.|..|..:..::.|.: ||.|.... .|.:.:|:.:..:.:..|..|     ||....|.
Frog   885 ISAATCFPEPFISEGRRLGYV-HRNFAGNRFSDHVALLSVFQAWDDARMGGEEAETRFCEHKRLN 948

  Fly   557 YRNLKRAHSLREQLITVARKKYGIP-------IFSCKG---DVEKLCKCITAGFFTQVAYLHHSG 611
            ...|:.....:.||..:.... |.|       :|:..|   :::.:...:..|.:..|.|....
Frog   949 MATLRMTWEAKVQLKEILVNS-GFPEECLMTQVFNNTGPDNNLDVVISLLAFGVYPNVCYHKEK- 1011

  Fly   612 VYRQI--SSGTELAIHPNST---------LYTLPQAQYVVYGELLQTTKLFMNYVTVIK------ 659
              |:|  :.|....||.:|.         .|..|   :.|:.|.::|..:....:|::.
Frog  1012 --RKILTTEGRNALIHKSSVNCPFSNQDLKYPSP---FFVFSEKIRTRAISAKGMTMVSPLQLLL 1071

  Fly   660 ---------------REWLTELAPH 669
                           .:|:....||
Frog  1072 FASKKVMSDGEFILLDDWIRLSLPH 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	208/737 (28%)
		DEXDc	64..202	CDD:238005	59/148 (40%)
		HELICc	289..380	CDD:197757	37/90 (41%)
		HA2	448..534	CDD:214852	25/86 (29%)
		OB_NTP_bind	<581..670	CDD:285018	21/131 (16%)
dhx9	XP_002937403.1	DSRM_DHX9_rpt1	3..71	CDD:380683
		DSRM_DHX9_rpt2	181..255	CDD:380684
		DEXHc_DHX9	333..565	CDD:350730	73/192 (38%)
		HrpA	345..>1054	CDD:224557	205/696 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910