DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and Dhx30

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001239612.1	Gene:	Dhx30 / 72831	MGIID:	1920081	Length:	1223	Species:	Mus musculus

Alignment Length:	685	Identity:	205/685 - (29%)
Similarity:	318/685 - (46%)	Gaps:	96/685 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGL-----IGITE 99
            :.::..:||:..:||.||..:|:|.||::.|:||.||:|::||.|.| .:.|:|.     :.||:
Mouse   456 IWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLE-RYVTEGRGARCNVIITQ 519

  Fly   100 PRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCT--KIKFMTEGILLREVLADPLLTQYG 162
            |||:|.|::|.||:.|.|..:...||:.|| |||.....  .:.|.|.|||||::.::|.|....
Mouse   520 PRRISAVSVAQRVSHELGPSLRRNVGFQVR-LESKPPARGGALLFCTVGILLRKLQSNPSLEGVS 583

  Fly   163 VIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEG 227
            .:||||.|||::.||.:|.|||.:.|...:|:|::.|||.|...||.:|     |...| :.:.|
Mouse   584 HVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYF-----GGCPV-IKVPG 642

  Fly   228 RMHPVSNFYL---------------------NEPCADYVKETVETVWKLHQKEPPGDILAFLTGQ 271
            .|:||...||                     .:.||..:....:.|..:..:..||.||.||.|.
Mouse   643 FMYPVKEHYLEDILAKLGKHQYPHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGW 707

  Fly   272 EEVLEALDLLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPG 336
            :|:......|:|.:...|.:.| :||::.::...||.::|..||.|.||:||||||||||||:..
Mouse   708 QEIKGVQQRLQEALGMHESKYL-ILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVND 771

  Fly   337 IVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQ 401
            ||:|:|.|..|.:.|:.||....|..|.||:|:.|||.|||||.:.|..|.|:.:|..|.:.|.|
Mouse   772 IVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQ 836

  Fly   402 PPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYL- 465
            .||:.|:.|...:||.|         ...|.....:.|..|::|. .:.|:||...|.:.:|.|
Mouse   837 VPEILRTPLENLVLQAK---------IHMPEKTAVEFLSKAVDSP-NIKAVDEAVILLQEIGVLD 891

  Fly   466 -----------LAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIA 519
                       ||.:.....|:|.:.::....|...::.:::.|.     ..|.|:..|....:.
Mouse   892 QREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-----RDPFSSSLQNRAEVD 951

  Fly   520 HRKFEVAE---GDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLR-------------- 567
            ..|..::.   .|.:..:.|..|:.|....::...:...:..||..|.|||
Mouse   952 KVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQFSENIY 1016

  Fly   568 EQLITVARKKYGIPIFSCK--GDVEKLCK-CITAGFFTQVAYLHHSGVYRQISSGTELAIHPNST 629
            |..:........:|...|.  .:.|:|.| .:.||.:..:..:....|.||..      ..|||.
Mouse  1017 EAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGK------FKPNSV 1075

  Fly   630 LYTLPQAQYVVYGELLQTTKLFMNYVTVIKREWLT 664
            .|....      |.:|..........|.::..|||
Mouse  1076 TYRTKS------GNILLHKSTINREATRLRSRWLT 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	205/685 (30%)
		DEXDc	64..202	CDD:238005	60/144 (42%)
		HELICc	289..380	CDD:197757	45/90 (50%)
		HA2	448..534	CDD:214852	17/100 (17%)
		OB_NTP_bind	<581..670	CDD:285018	20/87 (23%)
Dhx30	NP_001239612.1	DEXDc	467..646	CDD:214692	75/186 (40%)
		DEXDc	481..622	CDD:238005	59/142 (42%)
		HELICc	715..814	CDD:197757	46/99 (46%)
		HA2	886..969	CDD:214852	13/87 (15%)
		OB_NTP_bind	1009..1131	CDD:285018	21/108 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810