Protein Alignment CG3225 and Dhx36

DIOPT Version :10

• Sequence 1: NP_608860.1
• Gene: CG3225 / 33680
• FlyBaseID: FBgn0031631
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_082412.2
• Gene: Dhx36 / 72162
• MGIID: 1919412
• Length: 1001
• Species: Mus musculus
• Alignment Length: 726
• Identity: 215/726 - (29%)
• Similarity: 347/726 - (47%)
• Gaps: 121/726 - (16%)

  Fly    44 RERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYL----YEWGWHTKGLIGITEPRRVS 104
            |::||....:.:::..:..|||.::.||||.||:|||.|::    .|.|..:...|..|:|||:|
Mouse   197 RKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRIS 261

  Fly   105 TVTLANRVAQERGELV--GDTVGYVVRFLESM-SSCTKIKFMTEGILLREVLADPLLTQYGVIIV 166
            .:::|.|||.||.|..  |::.||.:|....: .....|.:.|.||:|:.:.:|..|:....|::
Mouse   262 AISVAERVATERAESCGNGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVL 326

  Fly   167 DEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHP 231
            ||.||||:.:|:::.::|.:|..||.||:|:.|||::|..|||:|     |...: :.|.|...|
Mouse   327 DEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYF-----GNCPM-IHIPGFTFP 385

  Fly   232 VSNFYL-----------------------------------------NEPCADYVKE-------- 247
            |..:.|                                         .|....|:||
Mouse   386 VVEYLLEDIIEKIRYVPDQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKERWPAYIKELRTRYSAS 450

  Fly   248 TVETVWKLHQ-----------------KEPPGDILAFLTGQEEVLEALDLLREYIASSEQENLKV 295
            ||:.:..:..                 :|..|.||.||.|.:.:....|||...:.....:.| :
Mouse   451 TVDVLQMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDKFL-I 514

  Fly   296 LPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSL 360
            :|::..|.:.:|..||...|.|.||:|:|||||||||||..:|||||.|.:|...::.:....::
Mouse   515 IPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTM 579

  Fly   361 VIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNI 425
            ....||||:|.||.|||||::||..|.||.......|...|.||:.|:.|....||:|.|.:|.|
Mouse   580 SAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGI 644

  Fly   426 LRF--DFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCS 488
            ..|  ....||..:.::.:::.|..|.|:|:|..|| |:|..||.||....:.||:.......|.
Mouse   645 AYFLSRLMDPPSNEAVVLSIKHLMELSALDKQEELT-PLGVHLARLPVEPHIGKMILFGALFCCL 708

  Fly   489 EEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAE---GDFITMLNAYTGFVE---EGM-- 545
            :.::||.|.|..:..|..|   :.::....|.|| |:|:   .|.:|::||:.|:.|   .|.
Mouse   709 DPVLTIAASLSFKDPFVIP---LGKEKIADARRK-ELAKETRSDHLTVVNAFEGWEEAKRRGFRY 769

  Fly   546 TKEFCGQYFLIYRNLKRAHSLREQLIT-------VARKKYGIPIFSCKGDVEKLCKC-ITAGFFT 602
            .|::|.:|||....|:..|:::.|...       |:.:....|..:...|.||:.|. |.||.:.
Mouse   770 EKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRSPKDPKANINSDNEKIIKAVICAGLYP 834

  Fly   603 QVAYLH-HSGVYRQI------SSGTELAIHPNSTLYTLPQAQY--VVYGELLQTTKLFMNYVTVI 658
            :||.:. :.|..|::      |.|. ::|||.|.........|  ::|...::|:.:::..
Mouse   835 KVAKIRLNLGKKRKMVKVHTKSDGL-VSIHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYD---- 894

  Fly   659 KREWLTELAPH 669
                .||::|:
Mouse   895 ----CTEVSPY 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	38..>669	CDD:441249	214/724 (30%)
Dhx36	NP_082412.2	Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250|UniProtKB:Q9H2U1	1..193
		Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8	1..97
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250|UniProtKB:Q9H2U1	1..44
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H2U1	46..98
		DSM (DHX36-specific motif). /evidence=ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q9H2U1	46..68
		RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79	99..379		66/187 (35%)
		DEXHc_DHX36	200..379	CDD:350739	65/184 (35%)
		HrpA	208..>769	CDD:441249	179/572 (31%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	258..310		18/51 (35%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	327..330		2/2 (100%)
		RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79	380..621		67/241 (28%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	491..550		20/59 (34%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9H2U1	510..521		2/11 (18%)
		WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79	622..691		25/69 (36%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	631..690		20/59 (34%)
		OB_NTP_bind	824..910	CDD:400182	20/87 (23%)
		OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79	834..898		14/72 (19%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	842..853		2/10 (20%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	863..893		6/29 (21%)