DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and Dhx16

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_006524936.1	Gene:	Dhx16 / 69192	MGIID:	1916442	Length:	1049	Species:	Mus musculus

Alignment Length:	669	Identity:	290/669 - (43%)
Similarity:	420/669 - (62%)	Gaps:	33/669 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYL 84
            ||..:|:.|           :...|..||:..:|:::|..:..|||:|:.|||||||:||:||||
Mouse   386 SAQAQQKES-----------IQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYL 439

  Fly    85 YEWGWHTKGL-IGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGIL 148
            :|.|:..||: |..|:||||:.:::|.|||:|.|..:|:.|||.:||.:..|..|.:::||:|:|
Mouse   440 FEEGYTKKGMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGML 504

  Fly   149 LREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSW 213
            |||.|::|.|..|.|::|||||||.:.||::.||:|.:.|.|..||::::|||:|.:.||.||
Mouse   505 LREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATLDTARFSAFF-- 567

  Fly   214 PGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQKEPPGDILAFLTGQ-----EE 273
                :.:....|.||..||..||...|.|||::..|.:|.::|..:||||||.|||||     ||
Mouse   568 ----DDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQVSAVVEE 628

  Fly   274 VLEALDLLREYI--ASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPG 336
            :..|.::|::..  ..|:...|.|||:|.::.|..|..:|...|.|.||||:||||||||:||.|
Mouse   629 IEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEG 693

  Fly   337 IVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYE-ALAPR 400
            |:||:|.|:.|.|.|||:|..:||.:.|.|||||.||||||||:..||.:||||...|: .|...
Mouse   694 IIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEET 758

  Fly   401 QPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYL 465
            ..||::|:.|...:|.||:|||.:::.|||..|||.:.||.|||.|:||.|::..|.||.. |..
Mouse   759 TVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELTTS-GRK 822

  Fly   466 LAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQV-QSIFSRPASAVAQQSGRIAHRKFEVAEGD 529
            :||||...|||||:..|.:..|||||:|:.|:|.| .|||.||...|.....  |...|.:..||
Mouse   823 MAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADN--ARVNFFLPGGD 885

  Fly   530 FITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIPIFSCKGDVEKLCK 594
            .:.:||.||.:.|.|.:.::|.:.|:.:|:::||..:||||..:. ::..:.:.||:||..::.|
Mouse   886 HLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLL-ERVEVGLTSCQGDYVRVRK 949

  Fly   595 CITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYGELLQTTKLFMNYVTVIK 659
            .||:|:|...|.|..|| ||.:.....:.|||||:|:. .|.::::|.||:.|||.||..|..|:
Mouse   950 AITSGYFYHTARLTRSG-YRTVKQQQTVFIHPNSSLFE-QQPRWLLYHELVLTTKEFMRQVLEIE 1012

  Fly   660 REWLTELAPHYYQQTTVRD 678
            ..||.|:|||||:...:.|
Mouse  1013 SSWLLEVAPHYYKAKELED 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	280/637 (44%)
		DEXDc	64..202	CDD:238005	70/138 (51%)
		HELICc	289..380	CDD:197757	51/90 (57%)
		HA2	448..534	CDD:214852	36/86 (42%)
		OB_NTP_bind	<581..670	CDD:285018	37/88 (42%)
Dhx16	XP_006524936.1	PTZ00121	<147..>410	CDD:173412	8/34 (24%)
Dhx16	XP_006524936.1	HrpA	377..1036	CDD:224557	290/669 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730