DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and Dhx34

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001258381.1	Gene:	Dhx34 / 684903	RGDID:	1584452	Length:	1143	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	216/562 - (38%)
Similarity:	321/562 - (57%)	Gaps:	36/562 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGW 89
            ||..||    .....|..:|..|||.||.::||..|::||||::.|:||.||||||||||...|:
  Rat   145 QQKQAF----GRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGF 205

  Fly    90 -HTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVL 153
             |    :..|:|||::.::||.||..|.....|..|||.:||..:.|:.|||.|:|.|:|||::.
  Rat   206 SH----VACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQ 266

  Fly   154 ADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGE 218
            .:|.|.||.|:||||.|||::..|.:||:|:::|.:|..||:|:.||||:.|.||.:||.
  Rat   267 CEPRLPQYQVLIVDEVHERHLHNDFLLGVLQRLLPQRPDLKVILMSATINISLFSSYFSH----- 326

  Fly   219 VSVKLSIEGRMHPVSNFYLNEPCADYVKET--------VETVWKLHQKEPP---GDILAFLTGQE 272
             :..:.:.||:.|::..|..:.......::        :..:..:..|.||   ||:|.||:|..
  Rat   327 -APVVQVPGRLFPITVVYQPQEAEQSASKSEKLDPRPFLRVLEAIDNKYPPEERGDLLVFLSGMA 390

  Fly   273 EVLEALDLLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGI 337
            |:...||..:.|...:::  ..|||::.::|..||..||...|.|.||.:|:|||||||:||.||
  Rat   391 EISTVLDAAQAYATLTQR--WVVLPLHSALSVADQDKVFDVAPAGVRKCILSTNIAETSVTIDGI 453

  Fly   338 VYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQP 402
            .:|:|.|.||...|:|:.....|....:|:|||.||.|||||..||..||||.:|||:|.||...
  Rat   454 RFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCYRLYAESDYDAFAPYPV 518

  Fly   403 PEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLA 467
            ||:||..|...:||:|::.:|:...|.|..||||.::.:|:..|....|:|....|| |:|.|||
  Rat   519 PEIRRVALDALVLQMKSMSVGDPRTFPFIEPPPAASVETAILYLQDQGALDSSEALT-PIGSLLA 582

  Fly   468 ELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAEGDFIT 532
            :||...::.||:.:......:|.::||.|.|.|||.|:|  ||.:......|.|..|..:||..|
  Rat   583 QLPVDVVIGKMMILGSMFSLAEPVLTIAAALSVQSPFTR--SAQSNLDCATARRPLESDQGDPFT 645

  Fly   533 MLNAYTGFVE-----EGMTKEFCGQYFLIYRNLKRAHSLREQ 569
            :.|.:..:|:     .|.::::|.:..:....|....:||.|
  Rat   646 LFNVFNAWVQVKSERSGNSRKWCRRRGVEEHRLYEMANLRRQ 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	212/547 (39%)
		DEXDc	64..202	CDD:238005	66/138 (48%)
		HELICc	289..380	CDD:197757	42/90 (47%)
		HA2	448..534	CDD:214852	31/85 (36%)
		OB_NTP_bind	<581..670	CDD:285018
Dhx34	NP_001258381.1	HrpA	155..>687	CDD:224557	211/546 (39%)
Dhx34	NP_001258381.1	OB_NTP_bind	798..909	CDD:400182
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810