DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and Dqx1

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_038964267.1	Gene:	Dqx1 / 680434	RGDID:	1591766	Length:	780	Species:	Rattus norvegicus

Alignment Length:	724	Identity:	199/724 - (27%)
Similarity:	327/724 - (45%)	Gaps:	112/724 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LMEQRERLPIRQYRDQILYCLEKHQ--VVILVGETGSGKSTQVPQYLYEW----GWHTKGLIGIT 98
            |:|||..|||...|...|..||...  ||::.||.|||||||:||:..|:    |:.| |.:.:|
  Rat    35 LLEQRRALPIWAARFLFLEHLESSPTGVVLVSGEPGSGKSTQIPQWCAEFALARGFQT-GQVTVT 98

  Fly    99 EPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGV 163
            :|..::.::||:|||.|....:|..:||.:...:.....|.::|..:.:.|:||.:......:.|
  Rat    99 QPYPLAAMSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSV 163

  Fly   164 IIVDEAHERNMLTDMILGLLKKILRKRS----SLKLIISSATIDASFFSEFFSWPGSGEVSVKLS 224
            :::|||.||::.:|::.|||:. .|.|:    ...:|::.:.::..|  :.| |..|..|.|..
  Rat   164 LVLDEAQERSVASDLLQGLLRD-TRLRNLPGDPRVVIVTDSALEPKF--QAF-WGNSPTVHVPR- 223

  Fly   225 IEGRMHPVSNFYLNEPCADYVKETVETVWKLHQK-EPPGDILAFLTGQEEVLEALDLLREYIASS 288
             |...:|...:....| ||.|:...:.|.:|.|: |.|||:|.:|..:||:....:.|     |.
  Rat   224 -EPGENPTLTYKDTVP-ADLVEAACQAVLELCQREEAPGDVLVYLPSEEEISLCCESL-----SR 281

  Fly   289 EQENL-------KVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYV 346
            |...|       :|||::.......| :|:.......||:|:...:|:.|.::|.|.:|||.|..
  Rat   282 EMGMLAVPGPLPRVLPLHPGCGQAIQ-TVYEDTDVSVRKIVVTHWLADFSFSLPFIQHVIDSGLE 345

  Fly   347 KVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQP-PEMRRSEL 410
            ....|||:..::|.|:..:||..|..|..||....||...|||:||..:..||..| |::....|
  Rat   346 LRSVYNPRIRAESQVLRRISKCQAEARLLRARGFPPGTCLRLYSKSTLDLEAPPLPHPKVCEENL 410

  Fly   411 SGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAML 475
            |..:|.||...|.......|...|..:.|:.|||.|..|.|:|:.|:|: .:|.:|:|.|....|
  Rat   411 SSLVLLLKRKQIAEPGECHFLDRPAPEALMQALEDLDYLAALDDDGDLS-DLGIILSEFPLPPEL 474

  Fly   476 SKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAEGDFITMLNAYTGF 540
            :|.|..|.:..|.:|::|:.|:|.....|:||.....:.:.|   |..|.|:||..:::..|..|
  Rat   475 AKALLASCEFNCVDEMLTLAAMLTAAPGFTRPPLCAGEAALR---RGLEHADGDHSSLIQVYEAF 536

  Fly   541 VEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARK---KYGIPIFSCKGDVEKLCKCITAGFFT 602
            |:.|..:.:|....|.:..|.:|..||.:|:.:.::   ...:|.|..:.:...|.|.:.:|:|.
  Rat   537 VQSGADETWCQARGLSWEALCQARKLRAELLELMQRIELPLSLPAFGSEQNRRDLQKALLSGYFL 601

  Fly   603 QVAYLHHSGVYRQIS------------------SGTELAIHPNSTL-------YTLPQAQYVVYG 642
            :.  :...|:..::.                  |.|:..|.....|       ..|....|:.:.
  Rat   602 KA--MMRRGLMSKLPSDSLSTSGWPQTAPLAPYSATQAGITATPALAFFIFCASLLSPPMYLCFN 664

  Fly   643 ELLQTTKLFMNY---------------------------------------------VTVIKREW 662
            |:.:.|....||                                             |:.|:.|.
  Rat   665 EVARDTDGTGNYLLLTHKHVAQLSPYCVYRNRRTPAQPPTWVLYHRFSISKDNCLCTVSEIQPEM 729

  Fly   663 LTELAPHYY 671
            |.||||.|:
  Rat   730 LVELAPPYF 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	196/719 (27%)
		DEXDc	64..202	CDD:238005	46/147 (31%)
		HELICc	289..380	CDD:197757	29/97 (30%)
		HA2	448..534	CDD:214852	27/85 (32%)
		OB_NTP_bind	<581..670	CDD:285018	25/158 (16%)
Dqx1	XP_038964267.1	HrpA	15..>601	CDD:224557	178/583 (31%)
Dqx1	XP_038964267.1	OB_NTP_bind	662..737	CDD:400182	12/74 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820