DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and YTHDC2

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_011541883.1	Gene:	YTHDC2 / 64848	HGNCID:	24721	Length:	1439	Species:	Homo sapiens

Alignment Length:	861	Identity:	223/861 - (25%)
Similarity:	347/861 - (40%)	Gaps:	273/861 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEW 87
            ||.:..:|             |:.||:.:.:::|:..:::::||::||||||||:||:||:|.:
Human   182 GESEFDSF-------------RQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLD- 232

  Fly    88 GWHTKGL---IGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILL 149
            .....|:   |..|:|||::.:.:|.|||.||.|.:|.|:||.:|....:|..|.:.|.|.|:||
Human   233 DCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLL 297

  Fly   150 REVLA-DPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSW 213
            |.::| |..|:....:||||.|||:..:|.:|..|:.:|:|..:||||:|||.:|.:.|..:|
Human   298 RTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYF-- 360

  Fly   214 PGSGEVSVKLSIEGRMHPVSNFYL----------NEPCADYVKE--------TVETVW------- 253
             ||..|   :.|:||...|...:|          |:....|.||        |..|.|
Human   361 -GSCPV---IYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQENS 421

  Fly   254 ------------------------------KLHQK-----EP---------------PGDILAF- 267
                                          :|.:|     ||               ..||.||
Human   422 FKPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFA 486

  Fly   268 ------LT--------------------------------------------------------G 270
                  ||                                                        |
Human   487 QVFHLILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFG 551

  Fly   271 QEEVLEALDLLREYIASSEQENL------------------------------------------ 293
            |.|:   :|||..|.|:.|..||
Human   552 QTEI---VDLLESYSATLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLL 613

  Fly   294 -------------------------------------------KVLPMYGSMSSTDQLSVFFTPP 315
                                                       :|..::.:|.::||..|...||
Human   614 YNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADSTHRYQVFMLHSNMQTSDQKKVLKNPP 678

  Fly   316 KGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRM 380
            .|.||::|:|||||||||:..:|:|||.|.||.|.::.......|.:|.:||||||||.|||||.
Human   679 AGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRC 743

  Fly   381 RPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDF----PSPPPAQNLLS 441
            |||..:||:::..::.:...|.||:.|..|....|..|.|...|....||    |.||||..:.:
Human   744 RPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRN 808

  Fly   442 ALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSR 506
            |::.|..:||:|...:||: :||.||:||....|.||:..:..:.|.:.|:||...|..:..|..
Human   809 AVQMLKTIDAMDTWEDLTE-LGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVL 872

  Fly   507 PASAVAQQSGRIAHRKFEV-AEGDFITMLNAYTGFVE---EGMTKEFCGQYFLIYRNLKRAHSLR 567
            |..|..:::..:..::|.. |..|.:.:|.|:..:.:   :|..:.||.:.||....::....:|
Human   873 PTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMR 937

  Fly   568 EQLITVARKKYGIPIFSCKGDVEK----------LCKCITAGFFTQVAYLHHSGVYRQISSGTEL 622
            .||:...|.. |.......||:..          :...:.||.:..:.::....:........::
Human   938 TQLLGQLRAS-GFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKV 1001

  Fly   623 AIHPNSTLYTLPQAQY 638
            ..||.|   .|.|.||
Human  1002 RFHPAS---VLSQPQY 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	220/844 (26%)
		DEXDc	64..202	CDD:238005	63/141 (45%)
		HELICc	289..380	CDD:197757	45/175 (26%)
		HA2	448..534	CDD:214852	25/86 (29%)
		OB_NTP_bind	<581..670	CDD:285018	11/68 (16%)
YTHDC2	XP_011541883.1	R3H_DEXH_helicase	46..104	CDD:100077
		HrpA	189..>1016	CDD:224557	221/854 (26%)
		DEXHc_YTHDC2	193..368	CDD:350745	72/181 (40%)
		ANK repeat	505..537	CDD:293786	0/31 (0%)
		ANK repeat	539..564	CDD:293786	7/27 (26%)
		OB_NTP_bind	971..1066	CDD:369483	9/47 (19%)
		YTH	1288..1404	CDD:367840
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810