Protein Alignment CG3225 and DHX35

DIOPT Version :10

• Sequence 1: NP_608860.1
• Gene: CG3225 / 33680
• FlyBaseID: FBgn0031631
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_068750.2
• Gene: DHX35 / 60625
• HGNCID: 15861
• Length: 703
• Species: Homo sapiens
• Alignment Length: 692
• Identity: 339/692 - (48%)
• Similarity: 467/692 - (67%)
• Gaps: 34/692 - (4%)

  Fly     7 KFLKPETDDAITDSAGGEQQSSA------FVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQV 65
            ||.:|.|:.... |...|:||.|      .|:|....:.:.:||::||:.:.|:.|||.:|.:|.
Human     9 KFWRPGTEGPGV-SISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQT 72

  Fly    66 VILVGETGSGKSTQVPQYLYEWGWHTKG-LIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVR 129
            |::|||||.|||||:||||.|.||..:| ::|:|:||||:.||:|.|||:|||.::|..|||.:|
Human    73 VVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIR 137

  Fly   130 FLESMSS-CTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSL 193
            |.:.... .|:|||:|:|:|:||::.|||||:|.||::||||||.:.||:.:||||||.:||..|
Human   138 FDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDL 202

  Fly   194 KLIISSATIDASFFSEFFSWPGSGEVS-------VKLSIEGRMHPVSNFYLNEPCADYVKETVET 251
            :||::|||:||..|.:||:   ..|.|       |.|::|||..||..|||..|..||:|.||||
Human   203 RLIVASATLDADKFRDFFN---QNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKSTVET 264

  Fly   252 VWKLHQKEPPGDILAFLTGQEEVLEALDLL----REYIASSEQENLKVLPMYGSMSSTDQLSVFF 312
            |.|:||.|..||:||||||||||...:.:|    |....:..:.:|:|||||..:.|.:|:.||.
Human   265 VVKIHQTEGDGDVLAFLTGQEEVETVVSMLIEQARALARTGMKRHLRVLPMYAGLPSFEQMKVFE 329

  Fly   313 TPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRA 377
            ...:..|||::|||:|||||||.|||||||||:||::.|||:|..:.||:||||:|||.|||||.
Human   330 RVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRG 394

  Fly   378 GRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSA 442
            ||.|.||.|||||:..::.|.....|||:||.|:..|||||||||.|:|||.|.||||||:::.|
Human   395 GRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQA 459

  Fly   443 LESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRP 507
            ||.|:||..:|:...||:|:|..:||.|.:.|.:|||..||..|||:||::|.|::|:|:||..|
Human   460 LELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVP 524

  Fly   508 ASAVAQQSGRI-AHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLI 571
            .:   |:|..| .||||.|.|||.:||||.|..|::.....::|.::||.|:.|.||.::||||
Human   525 PN---QKSHAIRVHRKFAVEEGDHLTMLNIYEAFIKHNKDSKWCQEHFLNYKGLVRAATVREQL- 585

  Fly   572 TVARK---KYGIPIFSCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTL 633
               :|   |:.:|..|.:||.:.:.:||.:|||...|..|.:|.||.|....||.|||.|.||..
Human   586 ---KKLLVKFQVPRKSSEGDPDLVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAE 647

  Fly   634 PQAQYVVYGELLQTTKLFMNYVTVIKREWLTELAPHYYQQTT 675
            ...::|:|.|::||:|.:|..||.|:..||.|||||:|||.|
Human   648 KPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGT 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	38..>669	CDD:441249	322/647 (50%)
DHX35	NP_068750.2	HrpA	54..>701	CDD:441249	326/646 (50%)
		DEAH box	176..179		2/2 (100%)