DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and DHX35

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_068750.2	Gene:	DHX35 / 60625	HGNCID:	15861	Length:	703	Species:	Homo sapiens

Alignment Length:	692	Identity:	339/692 - (48%)
Similarity:	467/692 - (67%)	Gaps:	34/692 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KFLKPETDDAITDSAGGEQQSSA------FVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQV 65
            ||.:|.|:.... |...|:||.|      .|:|....:.:.:||::||:.:.|:.|||.:|.:|.
Human     9 KFWRPGTEGPGV-SISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQT 72

  Fly    66 VILVGETGSGKSTQVPQYLYEWGWHTKG-LIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVR 129
            |::|||||.|||||:||||.|.||..:| ::|:|:||||:.||:|.|||:|||.::|..|||.:|
Human    73 VVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIR 137

  Fly   130 FLESMSS-CTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSL 193
            |.:.... .|:|||:|:|:|:||::.|||||:|.||::||||||.:.||:.:||||||.:||..|
Human   138 FDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDL 202

  Fly   194 KLIISSATIDASFFSEFFSWPGSGEVS-------VKLSIEGRMHPVSNFYLNEPCADYVKETVET 251
            :||::|||:||..|.:||:   ..|.|       |.|::|||..||..|||..|..||:|.||||
Human   203 RLIVASATLDADKFRDFFN---QNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKSTVET 264

  Fly   252 VWKLHQKEPPGDILAFLTGQEEVLEALDLL----REYIASSEQENLKVLPMYGSMSSTDQLSVFF 312
            |.|:||.|..||:||||||||||...:.:|    |....:..:.:|:|||||..:.|.:|:.||.
Human   265 VVKIHQTEGDGDVLAFLTGQEEVETVVSMLIEQARALARTGMKRHLRVLPMYAGLPSFEQMKVFE 329

  Fly   313 TPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRA 377
            ...:..|||::|||:|||||||.|||||||||:||::.|||:|..:.||:||||:|||.|||||.
Human   330 RVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRG 394

  Fly   378 GRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSA 442
            ||.|.||.|||||:..::.|.....|||:||.|:..|||||||||.|:|||.|.||||||:::.|
Human   395 GRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQA 459

  Fly   443 LESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRP 507
            ||.|:||..:|:...||:|:|..:||.|.:.|.:|||..||..|||:||::|.|::|:|:||..|
Human   460 LELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVP 524

  Fly   508 ASAVAQQSGRI-AHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLI 571
            .:   |:|..| .||||.|.|||.:||||.|..|::.....::|.::||.|:.|.||.::||||
Human   525 PN---QKSHAIRVHRKFAVEEGDHLTMLNIYEAFIKHNKDSKWCQEHFLNYKGLVRAATVREQL- 585

  Fly   572 TVARK---KYGIPIFSCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTL 633
               :|   |:.:|..|.:||.:.:.:||.:|||...|..|.:|.||.|....||.|||.|.||..
Human   586 ---KKLLVKFQVPRKSSEGDPDLVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAE 647

  Fly   634 PQAQYVVYGELLQTTKLFMNYVTVIKREWLTELAPHYYQQTT 675
            ...::|:|.|::||:|.:|..||.|:..||.|||||:|||.|
Human   648 KPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGT 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	321/644 (50%)
		DEXDc	64..202	CDD:238005	79/139 (57%)
		HELICc	289..380	CDD:197757	53/90 (59%)
		HA2	448..534	CDD:214852	40/86 (47%)
		OB_NTP_bind	<581..670	CDD:285018	39/88 (44%)
DHX35	NP_068750.2	DEXDc	53..224	CDD:214692	92/173 (53%)
		DEXDc	73..211	CDD:238005	78/137 (57%)
		DEAH box	176..179		2/2 (100%)
		HELICc	301..396	CDD:197757	52/94 (55%)
		HA2	465..549	CDD:214852	40/86 (47%)
		OB_NTP_bind	584..683	CDD:285018	42/102 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141449
Domainoid	1	1.000	233	1.000	Domainoid score	I2420
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6406
Inparanoid	1	1.050	634	1.000	Inparanoid score	I840
Isobase	1	0.950	-	0.864974	Normalized mean entropy	S807
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D189127at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto91268
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2486
SonicParanoid	1	1.000	-	-		X4895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750