DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and DHX37

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_005253647.1	Gene:	DHX37 / 57647	HGNCID:	17210	Length:	1175	Species:	Homo sapiens

Alignment Length:	787	Identity:	258/787 - (32%)
Similarity:	387/787 - (49%)	Gaps:	160/787 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTK-GLIGI 97
            ||.:..:.|:|.:|||......|:..:.:|.:||:.|||||||:|||||:|||.|:.:: .:||:
Human   239 VNRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGV 303

  Fly    98 TEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYG 162
            ||||||:.|.::.|||:|. .|....|.|.:|:..:::..|:|||||:|:||:|:..|.||.:|.
Human   304 TEPRRVAAVAMSQRVAKEM-NLSQRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYK 367

  Fly   163 VIIVDEAHERNMLTDMILGLLKKILRKRSS----LKLIISSATIDASFFSE---FFSWPGSGEVS 220
            |:|:||||||::.||:::|||.:|:..|:.    |||:|.|||:....|::   .|:.|     .
Human   368 VVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDFTQNPRLFAKP-----P 427

  Fly   221 VKLSIEGRMHPVS-NFYLNEPCADYVKETVETVWKLHQKEPPGDILAFLTGQEEV---------- 274
            ..:.:|.|..||: :|....|..||..|....|.|:|:..|.|.||.|||||.||
Human   428 PVIKVESRQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKA 492

  Fly   275 ---------------LEALDLLREYIAS------------------------------------S 288
                           .::::.:|::..|                                    .
Human   493 FPPSRARPQEKDDDQKDSVEEMRKFKKSRARAKKARAEVLPQINLDHYSVLPAGEGDEDREAEVD 557

  Fly   289 EQEN--------------------------LKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNI 327
            |:|.                          |.|||:|..::...|..||..||:|||..|:|||:
Human   558 EEEGALDSDLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNV 622

  Fly   328 AETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKS 392
            ||||:|||||.||:|||.||.::|:..|...|..:..||:|||.||||||||..||..||||:.:
Human   623 AETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSA 687

  Fly   393 DYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAID---- 453
            .:.......|||:.|..:...|||:|||.:..::.|.||:||..:.||:|.|.|.||.|:.
Human   688 VFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALLAAEELLIALGALQPPQK 752

  Fly   454 -------EQGNLTKPV---GYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIF---S 505
                   ::..|:.|:   |..:|..|.:...:|||.:|.|.||....|||:|.:.|:.:|   .
Human   753 AERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELD 817

  Fly   506 RPASAVAQQSGRIAHRKFEVAE--------------GDFITMLNAYTGFVEEGMTKEFCGQYFLI 556
            ||| |..::..|:..::..||:              ||.:.:|.|.........|.:||....|.
Human   818 RPA-ASDEELTRLKSKRARVAQMKRTWAGQGASLKLGDLMVLLGAVGACEYASCTPQFCEANGLR 881

  Fly   557 YRNLKRAHSLREQLITVAR-----------KKYGIPIFSCKGDVEKLCKCITAGFFTQVAYLHHS 610
            |:.:.....||.||.|...           .|...|   .:..|..|.:.:|||....:|....|
Human   882 YKAMMEIRRLRGQLTTAVNAVCPEAELFVDPKMQPP---TESQVTYLRQIVTAGLGDHLARRVQS 943

  Fly   611 ---------GVYRQISSGTELAIHPNSTLY-TLPQAQYVVYGELLQTTKLFMNYVTVIKREWLTE 665
                     ..|:.......:.|||:|.|: .||  ::|||.|:::|||::|..|:.::.:|:..
Human   944 EEMLEDKWRNAYKTPLLDDPVFIHPSSVLFKELP--EFVVYQEIVETTKMYMKGVSSVEVQWIPA 1006

  Fly   666 LAPHYYQ 672
            |.|.|.|
Human  1007 LLPSYCQ 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	253/775 (33%)
		DEXDc	64..202	CDD:238005	70/142 (49%)
		HELICc	289..380	CDD:197757	50/116 (43%)
		HA2	448..534	CDD:214852	30/116 (26%)
		OB_NTP_bind	<581..670	CDD:285018	28/98 (29%)
DHX37	XP_005253647.1	HrpA	240..1016	CDD:224557	257/786 (33%)
		DEXDc	271..411	CDD:238005	70/140 (50%)
		P-loop_NTPase	<368..>511	CDD:304359	48/147 (33%)
		HELICc	585..674	CDD:197757	47/88 (53%)
		HA2	768..859	CDD:214852	25/91 (27%)
		OB_NTP_bind	894..1011	CDD:285018	32/121 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820