DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and dhx30

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_021322211.1	Gene:	dhx30 / 570735	ZFINID:	ZDB-GENE-130530-833	Length:	1173	Species:	Danio rerio

Alignment Length:	741	Identity:	210/741 - (28%)
Similarity:	351/741 - (47%)	Gaps:	132/741 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ETDDAITDSAGGEQQSSAFVFNVNH-NMGLMEQRER--------LPIRQYRDQILYCLEKHQVVI 67
            :.|:.|||:...:...:.......| :..|:...:|        ||:..:::.||..:...|||:
Zfish   350 DEDEFITDAITSKPYRALEPKEAEHLSQRLLSMWKRVGPARGAELPVDAHKESILEAVRSSQVVV 414

  Fly    68 LVGETGSGKSTQVPQYLYEWG-WHTKGL---IGITEPRRVSTVTLANRVAQERGELVGDTVGYVV 128
            :.||||.||:|::|::|.|.| ...:|.   :.:|:|||:|.|::|.|||.|.|..:...|||.|
Zfish   415 ISGETGCGKTTRIPRFLLEDGVLRGEGAECNVLVTQPRRISAVSVAQRVAHEIGPALQHCVGYQV 479

  Fly   129 RFLESM---SSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKR 190
            | |||.   .|...:.|:|.|:||:::.::|.|.....:||||.|||::.||::|.||:.:|..|
Zfish   480 R-LESRPPERSGGALLFLTLGVLLKKLQSNPRLEGISHVIVDEVHERDVQTDLLLHLLRCVLSLR 543

  Fly   191 SSLKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNE---------------- 239
            ..||:::.||:.|:...:::|     |...| |.:.|.||||...:|.:
Zfish   544 PELKVLLMSASGDSQRLAQYF-----GGCPV-LRVPGFMHPVRARFLEDMQLDSRRPLLDMGSTQ 602

  Fly   240 -----------------PCADYVKETVETVWKLHQKEPPGDILAFLTGQEEVLEALDLLREYIAS 287
                             |..|.|.:.::   .:|:...||.:|.||.|.:|:......|.|..|.
Zfish   603 WSAEVRGRMGKEENNVTPDLDLVADVID---HIHRTGEPGAVLCFLPGWQEIKAVQQQLEEKQAY 664

  Fly   288 SEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYN 352
            .....: :||::.||:.::|..||..||.|.||:|||||||||||||..||:|:|.|..|.:.|:
Zfish   665 RSGSQI-ILPLHSSMAVSEQQVVFQRPPAGQRKIVLATNIAETSITIDDIVHVVDAGVQKEQNYD 728

  Fly   353 PKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQL 417
            |:|...:|..|.:|:|:..||.|||||.:||..|.|:.:...|.:.|...||:.|:.|...::|.
Zfish   729 PRTKVSALNTVWISQANVTQRRGRAGRCQPGHSYHLFPRKQLERMEPFPVPEILRTPLESVVMQA 793

  Fly   418 KALGIGNILRFDFPS----PPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKM 478
            | :........||.|    .|..|.:.:|:::|..:..:|...:|| |:|:.::.:.....|.|:
Zfish   794 K-IHCPESKAEDFLSQVLDSPDTQAVRTAVKNLMDIGVLDASEDLT-PLGHHVSCMSCDPRLGKV 856

  Fly   479 LYVSGQMGCSEEIITIIAL---------LQVQSIFSRPASAVAQQSGRIAHRKFEVAEGDFITML 534
            |..|....|.:.:::::|.         ||.:::.|:..:.::..||           .|::...
Zfish   857 LVFSALFSCVQPVLSVVACLTRDPFYNSLQNRTLVSKAKAELSGSSG-----------SDYLVFS 910

  Fly   535 NAYTGFVEE---GMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIPIFSCKGDVEKLCKCI 596
            .....:.|:   ...:::..::.|...:|:..|.|.:|             ||     :.||:
Zfish   911 RVVQSWREQHSRDSRQDYLDKHTLSGASLRFIHGLMQQ-------------FS-----DNLCE-- 955

  Fly   597 TAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYV--VYGELLQTTKLFMNYVTVIK 659
             ||.      :.||....::||    .::..|....|..|..:  :|..|:|..|   ..||...
Zfish   956 -AGL------VDHSAECLRLSS----PVNQQSKEEQLITAVLLAGLYPNLIQVKK---GVVTKSG 1006

  Fly   660 R------EWLTELAPHYYQQTTV-RD 678
            |      .:.||..|....:::| ||
Zfish  1007 RFRAENVSFRTESGPVLLHRSSVNRD 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	201/699 (29%)
		DEXDc	64..202	CDD:238005	61/144 (42%)
		HELICc	289..380	CDD:197757	44/90 (49%)
		HA2	448..534	CDD:214852	17/94 (18%)
		OB_NTP_bind	<581..670	CDD:285018	23/96 (24%)
dhx30	XP_021322211.1	HrpA	371..>929	CDD:224557	175/581 (30%)
dhx30	XP_021322211.1	OB_NTP_bind	947..1069	CDD:311586	27/120 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810