DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and dhx32b

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_687318.4	Gene:	dhx32b / 558937	ZFINID:	ZDB-GENE-130613-5	Length:	729	Species:	Danio rerio

Alignment Length:	669	Identity:	196/669 - (29%)
Similarity:	337/669 - (50%)	Gaps:	70/669 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEW---GWHTKGLIGITEPR 101
            |:.:|:.||:.:.:.:.:..|...|:||:.|...:|:|||:||:..|:   ..:..|::..|:..
Zfish    44 LLRERKCLPVWEAKCEFMDSLINSQIVIVTGTAKTGQSTQIPQWCAEFCLSAQYQNGMVVCTQIH 108

  Fly   102 RVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIV 166
            ..:||.||.|||.|....:|:.|||.:......|..|.:::.|:.:||||:::||||.|.||:::
Zfish   109 HQTTVELALRVADEMDVNIGNEVGYSIPLQACCSQDTVLRYCTDDVLLREMMSDPLLEQCGVVVL 173

  Fly   167 DEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSVK-------LS 224
            |:|.||.:.||::|||||.:|..|..|:|:|.||             |.|.|..::       :.
Zfish   174 DQAQERTVSTDLLLGLLKDVLLTRPELRLVILSA-------------PHSSEKLLRHYGSVPQIK 225

  Fly   225 IEGRMHPVSNFYLNEPC-----------ADYVKETVETVWKLHQKEPPGDILAFLTGQEEVLEAL 278
            :||          .:||           .||:...:....::||.|..|||:|||..::|:..|.
Zfish   226 LEG----------PQPCEVLFGSGRGGVKDYLCSALRLALEIHQNENHGDIVAFLATEQEIECAH 280

  Fly   279 DLLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSI-TIPGIVYVID 342
            .:||...|:....:.:::|:.......|.||:  |....:|:|.|..:.:|... .:..|.:|||
Zfish   281 AILRREGANLALSHGELVPVSLCPRQGDSLSL--TEESKSRRVFLTCSPSEDLFWALHTIRFVID 343

  Fly   343 CGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRR 407
            .|..|...|||:..::|:||.|:||:.|..|...||  ..||.:.||.:.  .:|.....|.:..
Zfish   344 AGVQKRYVYNPRIRANSIVIRPISKSQAESRKQLAG--PTGKCFCLYQED--TSLPAESVPHLLE 404

  Fly   408 SELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFS 472
            |:::..:|.||.:.|..:...|....|..:.|:.|||.|..|.|:|:.|||:: :|.:::|.|..
Zfish   405 SDITSTVLFLKRMEIAGLSHCDLIDRPDPEGLMQALEELDYLAALDDDGNLSE-IGIIMSEFPLE 468

  Fly   473 AMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAEGDFITMLNAY 537
            ..::|.|..|.:..|..|::||.|:|...|.|..|...: :|...:.|:||:.||||..|::|.:
Zfish   469 PQMAKTLLASCEFDCVCEVLTIAAMLTAPSCFIIPPVEM-RQKALLCHQKFQHAEGDHFTLINIF 532

  Fly   538 TG--FVEEG---MTKEFCGQYFLIYRNLKRAHSLREQLITVARK---KYGIPIFSCKGDVEKLCK 594
            ..  :.::|   ..:::|.::||....|:.|.::|.:|..:.::   ...:|.|..:.:...:.:
Zfish   533 NAYRYAKDGSYSKVEQWCDEHFLSLAALQTADAIRSELTEILKRLELPVSLPAFGSRSNSLNVRR 597

  Fly   595 CITAGFFTQVAY-LHHSGVYRQISSGTELAIHPNS------TLYTLPQAQYVVYGELLQTTKLFM 652
            .:.||||.|||. :..||.|..::......|||.|      ....||  ::|:|.|...:....:
Zfish   598 ALLAGFFMQVARDIDGSGNYFMLTHKHVAQIHPLSGYGLEVNKKNLP--EWVLYHEHTLSENNCI 660

  Fly   653 NYVTVIKREWLTELAPHYY 671
            ..|:.|......::||.|:
Zfish   661 RTVSQISAIEFIQMAPQYF 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	193/664 (29%)
		DEXDc	64..202	CDD:238005	57/140 (41%)
		HELICc	289..380	CDD:197757	28/91 (31%)
		HA2	448..534	CDD:214852	30/85 (35%)
		OB_NTP_bind	<581..670	CDD:285018	25/95 (26%)
dhx32b	XP_687318.4	HrpA	30..661	CDD:224557	191/649 (29%)
		DEXDc	68..207	CDD:238005	55/138 (40%)
		HA2	445..529	CDD:214852	30/85 (35%)
		OB_NTP_bind	568..678	CDD:285018	26/111 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920