DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3225 and dhx57

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_001921063.3	Gene:	dhx57 / 555250	ZFINID:	ZDB-GENE-030131-4078	Length:	1431	Species:	Danio rerio

Alignment Length:	790	Identity:	224/790 - (28%)
Similarity:	357/790 - (45%)	Gaps:	187/790 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 MGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHT-----KGLIGI 97
            :.:.|||::||..|.|:.||.||.|:||:::.|.||.||:||:||::.:....|     ...|..
Zfish   574 ISMQEQRQKLPAWQKREAILECLVKNQVLVISGMTGCGKTTQIPQFILDNFLQTGRPDRVANIIC 638

  Fly    98 TEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYG 162
            |:|||:|.:.:|.||||||.|.:|.:.||.:|.....||.|::.|.|.|:|||.:..||.|:...
Zfish   639 TQPRRISAIAVATRVAQERAEALGHSTGYQIRLETVRSSITRLMFCTTGVLLRRLEGDPELSGVT 703

  Fly   163 VIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFF-SWPGSGEVSVKLSIE 226
            .:||||.|||...:|.:|.:||.::.||:.||:|:.|||::|..||::| :.|       .:.|.
Zfish   704 HVIVDEVHERTEESDFLLLVLKDLIVKRTDLKVIMMSATLNAELFSQYFNNCP-------CIHIP 761

  Fly   227 GRMHPVSNFYLNEPCA------------------------------------------------- 242
            ||..||..|:|.:..|
Zfish   762 GRTFPVEQFFLEDAIAKTRYVIEDGSPYRRSTKLNRSSGPGGKTGKGRALVEDFDDDYGGWSFTS 826

  Fly   243 --------------------------DYVKETVETV------------------WKL--HQKEPP 261
                                      :|.|..|:|:                  |.:  ....||
Zfish   827 FRNKESVKDSVPDQQLSQQDLTVRYSNYSKSVVKTLAAMDLDKINMDLVESLLEWIVDGDHSYPP 891

  Fly   262 GDILAFLTGQEEVLEALDLLREYIASSEQENLK------VLPMYGSMSSTDQLSVFFTPPKGTRK 320
            |.:|.||.|..|:.:    |.|.:.|:...|.:      |.|::.|:|:.:|.:||..|..|..|
Zfish   892 GAVLVFLPGLAEIKQ----LYEQLQSNRMFNNRRTNRCVVYPLHSSLSNEEQQAVFTRPQNGVTK 952

  Fly   321 VVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKV 385
            ::::|||||||:||..:|||||.|.:|.|.|:.....:||..|.||:|:|:||.|||||:..|..
Zfish   953 IIISTNIAETSVTIDDVVYVIDSGRMKEKRYDASRSMESLEDVWVSRANALQRKGRAGRVASGVC 1017

  Fly   386 YRLYTKSDYE-ALAPRQPPEMRRSELSGAILQLKALGIGNILRFD-----FPSPPPAQNLLSALE 444
            :.|:|...:| .|:.:|.||::|..|....|::|.|.:......|     ...||...:|.:|.:
Zfish  1018 FHLFTSHRFEHHLSQQQLPEIQRVPLEQLCLRVKVLEVFAERPLDSVFSQLIEPPTEGSLEAAKQ 1082

  Fly   445 SLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRP-- 507
            .|.||.|:.::.:|| |:|:.||.||....:.|::.:.....|.:..:||.|.|..:|.|..|
Zfish  1083 RLCALGALTDEESLT-PLGWHLACLPVDVRIGKLMLLGAIFRCLDPALTIAASLAFKSPFVSPWD 1146

  Fly   508 --ASAVAQQSGRIAHRKFEVAEGDFITMLNAYTGFVEEGMT-----KEFCGQYFLIYRNLKRAHS 565
              ..|..::.|      |.:|..|.:.::.||.|:.....:     .::|.:.||..|.|:....
Zfish  1147 KREEANEKKLG------FSLANSDHLALMQAYKGWCNAAQSGFKAGYQYCRENFLSIRGLQEIAC 1205

  Fly   566 LREQ----LITVARKKYG-----IPIFSCKG----------------DVEKLCKC-ITAGFFTQV 604
            |:.|    |..:...|.|     |...|.||                |..||... :.|..:..|
Zfish  1206 LKRQFAELLSDIGFVKDGLKARVIEKMSSKGSDGVLEATGYEANLNSDNTKLMSAMLCAALYPNV 1270

  Fly   605 AYLHHSGV-YRQISSGT------------------ELAIHPNSTLYTLP--QAQYVVYGELLQTT 648
            ..:....: |:..|.|.                  .:.|||:|..:::.  .:.|:||.|.::|:
Zfish  1271 VQVRSPQMKYKLTSKGAMKMQPKAEEQRFMTKSDGAVHIHPSSVNFSVRHYDSPYLVYHEKVKTS 1335

  Fly   649 KLFMNYVTVI 658
            ::|:...:::
Zfish  1336 RVFIRDCSMV 1345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	224/788 (28%)
		DEXDc	64..202	CDD:238005	60/142 (42%)
		HELICc	289..380	CDD:197757	42/96 (44%)
		HA2	448..534	CDD:214852	25/89 (28%)
		OB_NTP_bind	<581..670	CDD:285018	21/116 (18%)
dhx57	XP_001921063.3	UBA_like_SF	199..240	CDD:328731
		MOT2	<310..511	CDD:227502
		HrpA	538..1420	CDD:224557	224/790 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900