DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and dhx29

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_697933.6	Gene:	dhx29 / 553505	ZFINID:	ZDB-GENE-130530-606	Length:	1377	Species:	Danio rerio

Alignment Length:	754	Identity:	227/754 - (30%)
Similarity:	356/754 - (47%)	Gaps:	158/754 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGLIG-------- 96
            |:::|::||:.|:|:|:|..|..|:|:::.||||||||||:||::.|      .|:.
Zfish   567 LLDERKQLPVFQHREQVLEALRHHRVLVIAGETGSGKSTQIPQFILE------ELLAAGDTAQPC 625

  Fly    97 ---ITEPRRVSTVTLANRVAQERGELVG-----DTVGYVVRFLESMSSCTKIKFMTEGILLREVL 153
               :|:|||:|.::||.||:||.|...|     ...||.:|.....|..|::.:.|.|:|||::.
Zfish   626 SVVVTQPRRISAMSLACRVSQELGSEDGPGSMNSLCGYQIRMENRSSEATRLLYCTTGVLLRKLQ 690

  Fly   154 ADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFS-WPGSG 217
            .|..|.....|||||.|||::.:|.:|.:||:::.||:.|:||:.|||:|...|:.:|: .|
Zfish   691 QDRHLNSLTHIIVDEVHERSVQSDFLLTILKEVVHKRADLRLILMSATVDCQKFANYFNRCP--- 752

  Fly   218 EVSVKLSIEGRMHPVSNFYLN----------EPCADYVKETVE---------------TV----- 252
                .:||.||..||..|:|.          |..::|.::.||               ||
Zfish   753 ----VVSIPGRTFPVEVFHLEDIVEETGYVLEQDSEYSQKFVEEEEEVNIGITQKGGKTVQHQEL 813

  Fly   253 --------WKL------------H----------------------QKEP-----PGDILAFLTG 270
                    |.|            |                      .|.|     .|.:|.||.|
Zfish   814 IVRDSASGWDLGPELDHFSSRTRHILQYMNPNKINMDLILDLLAYLDKSPQFNAVDGAVLVFLPG 878

  Fly   271 QEEVLEALDLLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIP 335
            ...:.:..|||......|.::..|::.::.|:||.||.|.|..||.|.||:||:||||||.:|||
Zfish   879 LAHIQQLHDLLSTDKRFSSKDRYKLVALHSSLSSQDQSSAFTVPPAGVRKIVLSTNIAETGVTIP 943

  Fly   336 GIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPR 400
            .:|:|||.|..|...|:..:...|||.:.||||||:||.|||||:|.|..:|||.|..:|:....
Zfish   944 DVVFVIDTGRTKENRYHESSQMSSLVEMFVSKASALQRQGRAGRVREGFCFRLYPKFRFESFIDY 1008

  Fly   401 QPPEMRRSELSGAILQLKALGIGNILRFDFPSP----------PPAQNLLSALESLFALDAIDEQ 455
            ..||:.|..|....|        :|::.::.||          |..|.:.:|:..|..:.|..:.
Zfish  1009 SIPEILRVPLEELCL--------HIMKCEYGSPEDFLSRSLDAPQQQAVCNAVSLLRRIGACQQD 1065

  Fly   456 GNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAH 520
            .:...|:|:.||.||.:..:.|||......||.|.|.||.|.:..:|.|:.|.|  .::...:|.
Zfish  1066 THTLTPLGHHLAALPVNVKIGKMLIFGAIFGCLEPIATIAAAMSEKSPFATPMS--RKEEANLAK 1128

  Fly   521 RKFEVAEGDFITMLNAYTGFVE---EGMTKE--FCGQYFLIYRNLKRAHSLREQLITVARK---- 576
            ....||..|.:|:..||.|:..   ||...|  :|.::||....|.....::::|:.:..:
Zfish  1129 SALAVANSDHMTIYKAYLGWRSSRTEGTRAEMNYCRRHFLNRTALITIEEVKQELMRMVEQAGFV 1193

  Fly   577 --KYG------------IPIFSCKGDVEKLCKCITAGFFTQVAYLHHS---GVYRQISSGTELA- 623
              |.|            .|:.....||..:...:|||.:..|..:.:|   .|..::....|.|
Zfish  1194 SSKLGRTPRPRPSTETKAPLSISTQDVCVVKATLTAGLYDNVGRILYSPSLDVQERVVCVVETAQ 1258

  Fly   624 ----IHPNSTLYTLPQAQYVVYGELLQTTKLFMNYVTVI 658
                :||:|....|....::::.|.::.:|:|:...|:|
Zfish  1259 GKAHVHPSSVNRFLQTHGWMLFQEKVKYSKVFLKDTTLI 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	227/754 (30%)
		DEXDc	64..202	CDD:238005	59/153 (39%)
		HELICc	289..380	CDD:197757	46/90 (51%)
		HA2	448..534	CDD:214852	26/85 (31%)
		OB_NTP_bind	<581..670	CDD:285018	20/86 (23%)
dhx29	XP_697933.6	DEXDc	568..766	CDD:214692	79/210 (38%)
		DEXDc	591..738	CDD:238005	58/152 (38%)
		HELICc	841..996	CDD:238034	60/154 (39%)
		HA2	1065..1140	CDD:214852	24/76 (32%)
		OB_NTP_bind	1181..1309	CDD:285018	23/117 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810