DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3225 and dhx38

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_957170.1	Gene:	dhx38 / 393850	ZFINID:	ZDB-GENE-040426-1144	Length:	1258	Species:	Danio rerio

Alignment Length:	637	Identity:	263/637 - (41%)
Similarity:	394/637 - (61%)	Gaps:	17/637 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVS 104
            |:|||:.|||...|.|:|..:..:.:||:||||||||:||:.|||:|.|:.:.|::|.|:||||:
Zfish   556 LLEQRQYLPIFAVRQQLLNIIRDNNIVIVVGETGSGKTTQLTQYLHEDGYTSYGMVGCTQPRRVA 620

  Fly   105 TVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEA 169
            .:::|.||::|....:|:.|||.:||.:..|..|.||:||:||||||.|.:..|..|..:|:|||
Zfish   621 AMSVAKRVSEEMNSNLGEEVGYAIRFEDCTSEKTMIKYMTDGILLRESLRESDLDHYSAVIMDEA 685

  Fly   170 HERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSN 234
            |||::.||::.|||::::.:||.||||::|||:|:..|:.||     |.|.: ..|.||..||..
Zfish   686 HERSLNTDVLFGLLREVVSRRSDLKLIVTSATMDSDKFASFF-----GNVPI-FHIPGRTFPVDI 744

  Fly   235 FYLNEPCADYVKETVETVWKLHQKEPPGDILAFLTGQEEVLEALDLLREYIASSEQ-ENLKVLPM 298
            .:...|..|||:..|:...::|.....||||.|:.|||::....|.:.|.:|..|. ..|.|||:
Zfish   745 LFSKTPQEDYVEAAVKQALQIHLSGMVGDILIFMPGQEDIEVTSDQIVERLADLENAPALAVLPI 809

  Fly   299 YGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIV 363
            |..:.|..|..:|...|.|.||.::||||||||:|:.||::|:|.||.|:|.:||:...|:|.:.
Zfish   810 YSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVVDSGYCKLKVFNPRIGMDALQVY 874

  Fly   364 PVSKASAIQRAGRAGRMRPGKVYRLYTKSDYE-ALAPRQPPEMRRSELSGAILQLKALGIGNILR 427
            |:|:|:|.||||||||..||:.|||||:|.:: .:.....||::|:.|:..:|.||:||:.::|.
Zfish   875 PISQANANQRAGRAGRTGPGQCYRLYTQSAFKNEMLTTTIPEIQRTNLANVVLLLKSLGVQDLLL 939

  Fly   428 FDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEII 492
            |.|..|||..|:|:::..|:.|.|:|..|.|| |.|.|:.|.|....|||||.||..|.||.:|:
Zfish   940 FHFMDPPPEDNMLNSMYQLWILGALDNTGALT-PTGRLMVEFPLDPALSKMLIVSCDMSCSADIL 1003

  Fly   493 TIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIY 557
            .|:::|.|.|||.||... .::|.:: ..||.|.|.|.:|.||.|..:.....:..:|..:|:..
Zfish  1004 IIVSMLSVPSIFYRPKGR-EEESDQV-REKFSVPESDHLTYLNVYLQWKNNNYSSIWCNDHFIHT 1066

  Fly   558 RNLKRAHSLREQL--ITVARKKYGIPIFSCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGT 620
            :.:::...:|.||  |.|.:|   :.:.||..|.:.:.|||.|.:|.|.|.|...|.|..:.:|.
Zfish  1067 KAMRKVREVRAQLKDIMVQQK---MNLISCGSDWDVIRKCICAAYFHQAAKLKGIGEYVNVRTGM 1128

  Fly   621 ELAIHPNSTLYTLPQA-QYVVYGELLQTTKLFMNYVTVIKREWLTELAPHYY 671
            ...:||.|.|:.:... .|::|.||:.|||.:|..||.:..|||.||.|.:|
Zfish  1129 PCHLHPTSALFGMGYTPDYIIYHELVMTTKEYMQCVTAVDGEWLAELGPMFY 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	261/632 (41%)
		DEXDc	64..202	CDD:238005	69/137 (50%)
		HELICc	289..380	CDD:197757	45/91 (49%)
		HA2	448..534	CDD:214852	37/85 (44%)
		OB_NTP_bind	<581..670	CDD:285018	34/89 (38%)
dhx38	NP_957170.1	DEXDc	557..744	CDD:214692	90/192 (47%)
		DEXDc	580..718	CDD:238005	69/137 (50%)
		HELICc	793..892	CDD:197757	48/98 (49%)
		HA2	961..1043	CDD:214852	37/84 (44%)
		OB_NTP_bind	1077..1177	CDD:285018	38/102 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820