DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and Dhx35

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_006235485.1	Gene:	Dhx35 / 362260	RGDID:	1311165	Length:	703	Species:	Rattus norvegicus

Alignment Length:	699	Identity:	332/699 - (47%)
Similarity:	471/699 - (67%)	Gaps:	48/699 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KFLKPETD----------DAITDSAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLE 61
            ||.||.|:          .::|:::|     :..::|....:.:.:||::||:.:.|:.|||.:|
  Rat     9 KFWKPGTEGPGVSISEERQSVTENSG-----TTVIYNPYAALSIEQQRQKLPVFKLRNHILYLVE 68

  Fly    62 KHQVVILVGETGSGKSTQVPQYLYEWGWHTKG-LIGITEPRRVSTVTLANRVAQERGELVGDTVG 125
            .:|.|::|||||.||||||||||.|.||..:| ::|:|:||||:.||:|.|||.|||.::|..||
  Rat    69 NYQTVVIVGETGCGKSTQVPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEVG 133

  Fly   126 YVVRFLESMSSC-----TKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKK 185
            |.:||    ..|     |:|||:|:|:|:||::.|||||:|.|:::||||||.:.||:.:|||||
  Rat   134 YCIRF----DDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKK 194

  Fly   186 ILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVS-------VKLSIEGRMHPVSNFYLNEPCAD 243
            |.:||..|:||::|||:||..|.:||:   ..|.|       |.|::|||..||..|||..|..|
  Rat   195 IQKKRGDLRLIVASATLDAEKFRDFFN---QNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPD 256

  Fly   244 YVKETVETVWKLHQKEPPGDILAFLTGQEEVLEALDLL----REYIASSEQENLKVLPMYGSMSS 304
            |:|.||:||.|:||.|..|||||||||||||...:.:|    |....:..:::|:|||||..:.|
  Rat   257 YIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALARTGMKKHLRVLPMYAGLPS 321

  Fly   305 TDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKAS 369
            .:|:.||.......|||::|||:|||||||.|||||||||::|::.|||:|..:.||:||||:||
  Rat   322 FEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQAS 386

  Fly   370 AIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPP 434
            |.|||||.||.|.||.|||||:..:|.|.....|||:||.|:..:||||||||.::|||.|.|||
  Rat   387 ANQRAGRGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPP 451

  Fly   435 PAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQ 499
            |||:::.|||.|:||..:|:...||:|:|..:||.|.:.|.:|||..||..|||:||::|.|::|
  Rat   452 PAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQ 516

  Fly   500 VQSIFSRPASAVAQQSGRIAHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAH 564
            :|::|..|::..:|.: |: ||||.|.|||.:||||.|..|::...:.::|.::||.|:.|.||.
  Rat   517 IQNVFVFPSNQKSQAT-RV-HRKFAVEEGDHLTMLNVYEAFIKHNKSSQWCQEHFLNYKGLVRAA 579

  Fly   565 SLREQLITVARK---KYGIPIFSCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHP 626
            ::|:||    :|   |:.:|..|.:||.:.:.:||.:|||...|..|.:|.||.|....||.|||
  Rat   580 TVRDQL----KKLLVKFQVPKMSSEGDPDPVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHP 640

  Fly   627 NSTLYTLPQAQYVVYGELLQTTKLFMNYVTVIKREWLTELAPHYYQQTT 675
            .|.||.....::|:|.|::||:|.:|..||.|:..||.|||||:|||.|
  Rat   641 ASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGT 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	317/647 (49%)
		DEXDc	64..202	CDD:238005	80/143 (56%)
		HELICc	289..380	CDD:197757	52/90 (58%)
		HA2	448..534	CDD:214852	38/85 (45%)
		OB_NTP_bind	<581..670	CDD:285018	39/88 (44%)
Dhx35	XP_006235485.1	DEXDc	53..224	CDD:214692	93/177 (53%)
		DEXDc	73..211	CDD:238005	79/141 (56%)
		HELICc	301..396	CDD:197757	51/94 (54%)
		HA2	465..549	CDD:214852	38/85 (45%)
		OB_NTP_bind	584..683	CDD:285018	42/102 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335139
Domainoid	1	1.000	232	1.000	Domainoid score	I2334
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6406
Inparanoid	1	1.050	631	1.000	Inparanoid score	I807
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D189127at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto98352
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810