DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and mle

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster

Alignment Length:	736	Identity:	216/736 - (29%)
Similarity:	328/736 - (44%)	Gaps:	146/736 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYE------WGWHT 91
            |.|.....:|.||:|||...|.:||..:..:.|||:.|.||.||:||:.||:.:      .|.:.
  Fly   370 NDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYA 434

  Fly    92 KGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESM--SSCTKIKFMTEGILLREVLA 154
            .  |.:|:|||:|.:::|.|||:||.|.:||||||.||| ||:  .....|.|.|.|:|||::.|
  Fly   435 N--IYVTQPRRISAISVAERVARERCEQLGDTVGYSVRF-ESVFPRPYGAILFCTVGVLLRKLEA 496

  Fly   155 DPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGEV 219
            .  |.....|||||.|||::.:|.:|.:|:.::.....|.:|:.|||||.:.||::|.      :
  Fly   497 G--LRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFG------I 553

  Fly   220 SVKLSIEGRMHPVSNFYL----------------------------------------NEPCAD- 243
            ...|.:.||..||..|:|                                        |:.|.|
  Fly   554 CPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDK 618

  Fly   244 YVKETVETVWKLHQ-----------------KEPPGDILAFLTGQEEVLEALDLLREYIASSEQE 291
            |.::|...:..|.:                 |..||.||.||.|...:...:..|:......:..
  Fly   619 YSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTS 683

  Fly   292 NLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTC 356
            ..::||.:..:...:|..||...|:|..|::|:||||||||||..||:|||....::|.:.....
  Fly   684 QYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNN 748

  Fly   357 SDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALG 421
            ..|...|..||.:..||.|||||:|||..:.|.:::.::||.....|||.|:.|....|.:|.|.
  Fly   749 LTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLR 813

  Fly   422 IGNILRF--DFPSPPPAQNLLSA---LESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYV 481
            :|:|..|  ....|||...::.|   |..:..|||.||   || |:|.|||.||....|.||:.:
  Fly   814 LGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDE---LT-PLGRLLARLPIEPRLGKMMVL 874

  Fly   482 SGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAEG----DFITMLNAYTGFVE 542
            ....||: :::.|:|  ...|.||...|....|.....|:|  ...|    |.:.|:.|...:..
  Fly   875 GAVFGCA-DLMAIMA--SYSSTFSEVFSLDIGQRRLANHQK--ALSGTKCSDHVAMIVASQMWRR 934

  Fly   543 -----EGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIP--------------------- 581
                 |.|...||....|....:......::||:.:.::. |.|
  Fly   935 EKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQA-GFPEECMISHEVDERIDGDDPVLD 998

  Fly   582 ---IFSCKGDVEKLC------KCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQ 637
               ...|.|....:|      |.:|..  ::.|.||.:.|     :.:.||:       |.|. .
  Fly   999 VSLALLCLGLYPNICVHKEKRKVLTTE--SKAALLHKTSV-----NCSNLAV-------TFPY-P 1048

  Fly   638 YVVYGELLQTTKLFMNYVTVI 658
            :.|:||.::|..:....::::
  Fly  1049 FFVFGEKIRTRAVSCKQLSMV 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	214/729 (29%)
		DEXDc	64..202	CDD:238005	61/145 (42%)
		HELICc	289..380	CDD:197757	35/90 (39%)
		HA2	448..534	CDD:214852	30/89 (34%)
		OB_NTP_bind	<581..670	CDD:285018	18/108 (17%)
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	74/186 (40%)
		DEXDc	402..542	CDD:238005	61/144 (42%)
		ATP-synt_B	<584..644	CDD:304375	6/59 (10%)
		Helicase_C	643..772	CDD:278689	44/128 (34%)
		HA2	842..926	CDD:214852	30/92 (33%)
		OB_NTP_bind	974..1078	CDD:285018	19/112 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468092
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840