DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3225 and Rhau

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001260639.1	Gene:	Rhau / 35339	FlyBaseID:	FBgn0032883	Length:	942	Species:	Drosophila melanogaster

Alignment Length:	751	Identity:	226/751 - (30%)
Similarity:	361/751 - (48%)	Gaps:	127/751 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLKPETDDAITDSAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGET 72
            ::.|:.|:.:....|..|...    |....   :|.|::||..:|.|.|:..:.::||:::||.|
  Fly   121 WVNPKLDERLQLELGQRQLEE----NAKKR---LEARKKLPTMKYADDIIQAVRENQVILIVGST 178

  Fly    73 GSGKSTQVPQYLYE----WGWHTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLES 133
            |.||:|||||.|.:    .|..:...|..|:|||:|.:.:|..|:.||.|.:|::|||.:| |||
  Fly   179 GCGKTTQVPQILLDDAISRGCASSCRIICTQPRRISAIAIAEWVSYERCESLGNSVGYQIR-LES 242

  Fly   134 MSSCTK--IKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLI 196
            ..:..:  |.:.|.|:||:::.:|||:....|:|:||.|||::.||:::||||.||..|..||:|
  Fly   243 RKARERASITYCTTGVLLQQLQSDPLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVI 307

  Fly   197 ISSATIDASFFSEFF-SWPGSGEVSVKLSIEGRMHPVSNFYL----------------------- 237
            :.|||:....|.::| :.|       ...|||.|.||...||
  Fly   308 LMSATVREQDFCDYFNNCP-------MFRIEGVMFPVKMLYLEDVLSKTNYEFQKFRDRRPKRDP 365

  Fly   238 ----------------------------------NEPCADYVKETVETVWKLHQKEPPGDILAFL 268
                                              :|.|.| :....:.|:.:.:.||.|.||.||
  Fly   366 PERRMKHEAMIEPYLRRIRNSYDSRVLDKLRLPESEGCED-IDFIADLVYYICENEPEGAILVFL 429

  Fly   269 TGQEEVLEALDLLREYIASSEQ---ENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAET 330
            .|.:::.:..::|.:...|..|   :::.|.|::..|.|.:|.:||..||.|.|||:::|.||||
  Fly   430 PGYDKISQLYNILDKPKTSKGQRWRDHMAVFPLHSLMQSGEQQAVFRRPPAGQRKVIISTIIAET 494

  Fly   331 SITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYE 395
            |:||..:||||:.|..|...|:.:|...||..|.|:||:..||.|||||:|||..|.|::::..:
  Fly   495 SVTIDDVVYVINSGRTKATNYDIETNIQSLDEVWVTKANTQQRRGRAGRVRPGICYNLFSRARED 559

  Fly   396 ALAPRQPPEMRRSELSGAILQLKALGIGNILRF-----DFPSPPPAQNLLSALESLFALDAIDEQ 455
            .:.....||:.||:|...||.||.|.|.:..||     :.|:|   :.:...:|.|..::|:|:.
  Fly   560 RMDDIPTPEILRSKLESIILSLKLLHIDDPYRFLQTLINAPNP---EAIKMGVELLKRIEALDQT 621

  Fly   456 GNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRP---ASAVAQQSGR 517
            |.|| |:|..||:||....:.||:.:|....|.:.|.:..|.|..:|.|..|   .|.|.:...|
  Fly   622 GTLT-PLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAALSFKSPFYSPLGKESRVDEIKRR 685

  Fly   518 IAHRKFEVAEGDFITMLN---AYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYG 579
            :|..    ...|.:.:.|   ||.........::||.:.||....|::...::.|...:......
  Fly   686 MARN----MRSDHLMVHNTIIAYRDSRYSHAERDFCYKNFLSSMTLQQLERMKNQFSELLYNYKF 746

  Fly   580 IPIFSCKG-----DVEK---LCKCITAGFFTQVAYLHHSGVYRQISS------------GTELAI 624
            :...:||.     :.||   |...|.||.:..:|:|..|   |||.:            |..:..
  Fly   747 LASSNCKDAASNKNSEKIPLLRAIIGAGLYPNMAHLRKS---RQIKNRVRAIHTMATDDGRRVNF 808

  Fly   625 HPNSTLYTLP--QAQYVVYGELLQTTKLFMNYVTVI 658
            ||:|......  .:.|.||.:..::|.||:...|::
  Fly   809 HPSSVNSGESGFDSAYFVYFQRQKSTDLFLLDSTMV 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	221/719 (31%)
		DEXDc	64..202	CDD:238005	63/143 (44%)
		HELICc	289..380	CDD:197757	42/93 (45%)
		HA2	448..534	CDD:214852	26/88 (30%)
		OB_NTP_bind	<581..670	CDD:285018	25/100 (25%)
Rhau	NP_001260639.1	DEXDc	147..328	CDD:214692	74/188 (39%)
		DEXDc	170..312	CDD:238005	62/142 (44%)
		Helicase_C	411..544	CDD:278689	53/132 (40%)
		HA2	614..696	CDD:214852	26/86 (30%)
		OB_NTP_bind	735..853	CDD:285018	26/113 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468088
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I130
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.890