DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3225 and CG32533

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	188/556 - (33%)
Similarity:	295/556 - (53%)	Gaps:	41/556 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVS 104
            |.:.:..|||.::|..:...|:..:|||:.|:||.|||||||||||::|:.:   |..|:|||::
  Fly   139 LRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRRLA 200

  Fly   105 TVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEA 169
            .|:|..|||.|..:..|..|.:.:||..|.:..|.|.|:|||:|||::.....|.||..:|:||.
  Fly   201 CVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEI 265

  Fly   170 HERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSVKL-SIEGRMHPVS 233
            ||||:..|.:||:.|.:||.|..||||:.||||:...|..:|     ||...:| .:.||:.|:.
  Fly   266 HERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYF-----GEEGARLVQVPGRLFPIK 325

  Fly   234 NFYLNEPCADY------VKET----------VETVWKLHQKEPP---GDILAFLTGQEEVLEALD 279
            ..||..|..:.      .|.:          |:.:..:.|:.|.   ||:|.|::|..|:...::
  Fly   326 LRYLPPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVE 390

  Fly   280 LLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCG 344
            .:.||  ::||.:..|||::...:..||..||...|:|.||.:::|||||||:|:.|:.:|:|.|
  Fly   391 AVHEY--ATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSG 453

  Fly   345 YVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSE 409
            .||...::.......|....|||:||.||.|||||..||..:||||...|.|......||:.|..
  Fly   454 KVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVP 518

  Fly   410 LSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAM 474
            |...:||:.::|:.::..|.|...|..:.:...:.:|....|:..:..:| |:|..||.||....
  Fly   519 LDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSVEEKIT-PLGRSLANLPVELS 582

  Fly   475 LSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRK--FEVAEGDFITMLNAY 537
            :.|||.:.......|:::|:.|:|.||:    |.:..|....|....:  .|...||..|::..|
  Fly   583 IGKMLLMGSVFPEVEQLLTLAAMLSVQN----PLTNRAHTDQRCVRERESLESDHGDLFTLVRLY 643

  Fly   538 TGFVEEGM----TKEFCGQYFLIYRNLKRAHSLREQ 569
            ..:|:..|    |:::|.:..:..:.......||:|
  Fly   644 NVWVQLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQQ 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	188/556 (34%)
		DEXDc	64..202	CDD:238005	66/137 (48%)
		HELICc	289..380	CDD:197757	39/90 (43%)
		HA2	448..534	CDD:214852	24/87 (28%)
		OB_NTP_bind	<581..670	CDD:285018
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	77/179 (43%)
		DEXDc	163..298	CDD:238005	66/137 (48%)
		Helicase_C	358..490	CDD:278689	50/133 (38%)
		HA2	560..640	CDD:214852	24/84 (29%)
		OB_NTP_bind	<792..897	CDD:285018
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468090
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840