DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and CG8915

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster

Alignment Length:	655	Identity:	199/655 - (30%)
Similarity:	312/655 - (47%)	Gaps:	89/655 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKG--LIGI 97
            |.|..:..:|..|||.:.|:.||..|::.||:|:.|.||||||||:|||:.||....:.  .|.:
  Fly   197 NRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEHRAPVRIVV 261

  Fly    98 TEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLAD--PLLTQ 160
            ::|||::.::::.|:::||||..|.||||.:|.....||.|.:...|.|.|||.:..|  .....
  Fly   262 SQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKN 326

  Fly   161 YGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSG-------- 217
            ...:|:||||||::.||.:|...|..|:|...|:|::.|||:|....|.:|   |.|
  Fly   327 TTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYF---GGGTVMDVEGR 388

  Fly   218 --EVSVK-----LSIEGRMHPVSNFYLNEPCADYVKET------------------------VET 251
              |||:.     ||..|.|||....:|.:|..   |||                        |..
  Fly   389 SFEVSIYHLEDILSKTGYMHPRMEKFLGKPTG---KETPSELLAAYYGGNTIVHPDIDNDLIVSL 450

  Fly   252 VWKLHQKEPPGDILAFLTGQEEVLEALDLLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPK 316
            :..|.::...|.::.:|.|..::   ..||....:|..:|.:.::.::..:.:::|..||.|.|.
  Fly   451 LELLLRQGDAGAVIVYLPGYSDM---TSLLARLESSLPREQITIILLHSQVDNSEQRKVFRTYPG 512

  Fly   317 GTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMR 381
            ...|::|:|||.:||||||.::||||.|..|:|.|:....:..|.:..:|:|.|.||||||||:.
  Fly   513 VRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVC 577

  Fly   382 PGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALG----IGNILRFDFPSPPPAQNLLSA 442
            .|..||||.......:.....||:.|..|....|..|...    |.|.|.....: ||...::.:
  Fly   578 HGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAPDKKIENFLALALDT-PPKDAVMQS 641

  Fly   443 LESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRP 507
            ...|..|..:||:..:| |:|:::||||....:.|.|..|..:.|.:.:|.|.|...|:..|...
  Fly   642 CSRLKLLGVLDERDEVT-PLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLN 705

  Fly   508 ASAVAQQSGRIAHRKFEVAEG--DFITMLNAYTGF--VEEGMTKEFCGQYFLIYRN-----LKRA 563
            ... .::||:...|.....:|  |.:.::..|..|  ::.....:||.:.| |.||     :..|
  Fly   706 IER-GKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDFCERNF-ICRNAMEMFVSAA 768

  Fly   564 HSLREQLITVARKKYGIPIF-----------SCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQIS 617
            .:||:   ||.|      ||           |...|...:...:|||.:.::||:......:.::
  Fly   769 STLRD---TVYR------IFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMDRENKNQLVA 824

  Fly   618 SGTEL 622
            .|..|
  Fly   825 EGDPL 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	197/650 (30%)
		DEXDc	64..202	CDD:238005	58/141 (41%)
		HELICc	289..380	CDD:197757	36/90 (40%)
		HA2	448..534	CDD:214852	24/87 (28%)
		OB_NTP_bind	<581..670	CDD:285018	11/53 (21%)
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	71/183 (39%)
		DEXDc	226..368	CDD:238005	58/141 (41%)
		HELICc	479..575	CDD:197757	36/95 (38%)
		HA2	648..733	CDD:214852	24/86 (28%)
		OB_NTP_bind	783..884	CDD:285018	9/47 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468087
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840