DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and kz

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster

Alignment Length:	854	Identity:	247/854 - (28%)
Similarity:	371/854 - (43%)	Gaps:	227/854 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KP--KFLKPETDDAITDSAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVI 67
            ||  |.||||.:....      ...:.:| .|:....:...|.||||.....|::..:.::.:||
  Fly   223 KPPIKKLKPEPNPPAC------IHQTVYV-PVHRTTEVQNARLRLPILAEEQQVMETINENPIVI 280

  Fly    68 LVGETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLE 132
            :.|||||||:||:||:|||.|:....:||:||||||:.:.::.|||.|. .|....|.|::||..
  Fly   281 VAGETGSGKTTQLPQFLYEAGYAQHKMIGVTEPRRVAAIAMSKRVAHEM-NLPESEVSYLIRFEG 344

  Fly   133 SMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKIL----RKRSSL 193
            :::..|:|||||:|:||:|:..|.||::|.|||:||||||::.||:::|||.:|:    ::...|
  Fly   345 NVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPL 409

  Fly   194 KLIISSATIDASFFSE---FFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKL 255
            ||||.|||:..|.|:|   .|..|     ...|.:|.|..||:..:......|||.|......|:
  Fly   410 KLIIMSATLRVSDFTENTRLFKIP-----PPLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLKI 469

  Fly   256 HQKEPPGDILAFLTGQEEVLEALDLLR-------------------------------------- 282
            |.|.|.|.||.|:|||:||.:.:..||
  Fly   470 HNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDP 534

  Fly   283 -------------------EYIA-----------------------------SSEQENLK----- 294
                               :::|                             ..|||.|:
  Fly   535 KELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDD 599

  Fly   295 -------------------VLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYV 340
                               |||:|..:||..|..:|...|.|.|..|::||:||||:|||.|.||
  Fly   600 ELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYV 664

  Fly   341 IDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDY-EALAPRQPPE 404
            :|||..|.:.|:..|...:.|:...|||||.||||||||:..|..||||:.:.| :.......|:
  Fly   665 VDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPD 729

  Fly   405 MRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAID----EQGNLTKPV--- 462
            :::..:...:||::.:||..::.|.|||||....|.:|...|..|.|::    |..:|...|
  Fly   730 IQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRL 794

  Fly   463 GYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPA----SAVAQQSGRIAHRKF 523
            |::::..|.:....|||.:|.|.......:.::|.|.||.:.....    ..||..:.|. |||.
  Fly   795 GHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGANRF-HRKR 858

  Fly   524 E--VAEGDF------ITMLNA-----YTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLIT--- 572
            :  .|.|::      :.:|.|     |.|  .:|...|||....|..:.:.....||.||..
  Fly   859 QSWAASGNYQLLGDPMVLLRAVGAAEYAG--SQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEIN 921

  Fly   573 ------------------------------------VARKKYGIPI--FSCKGDVEKLCKCITAG 599
                                                ||||   :|:  .:.|.:..:|.......
  Fly   922 LNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARK---VPLADIADKEERRRLKYAYNCA 983

  Fly   600 FFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYGELLQ-----TTKLFMNYVTVIK 659
            ...:.|:||.|.|.||                  ...::|:|.|..:     :||:|:..:|.|:
  Fly   984 DMEEPAFLHVSSVLRQ------------------KAPEWVIYQEAYELQNGDSTKMFIRGITAIE 1030

  Fly   660 REWLTELAP 668
            .|||....|
  Fly  1031 PEWLLLYVP 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	237/815 (29%)
		DEXDc	64..202	CDD:238005	70/141 (50%)
		HELICc	289..380	CDD:197757	47/114 (41%)
		HA2	448..534	CDD:214852	24/104 (23%)
		OB_NTP_bind	<581..670	CDD:285018	22/95 (23%)
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	240/840 (29%)
		DEXDc	279..418	CDD:238005	70/139 (50%)
		P-loop_NTPase	369..>500	CDD:304359	55/135 (41%)
		HELICc	619..704	CDD:197757	43/84 (51%)
		HA2	774..859	CDD:214852	22/85 (26%)
		OB_NTP_bind	915..1039	CDD:285018	27/144 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468052
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850