DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and Dhx38

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_006255639.1	Gene:	Dhx38 / 292007	RGDID:	1310345	Length:	1227	Species:	Rattus norvegicus

Alignment Length:	682	Identity:	276/682 - (40%)
Similarity:	410/682 - (60%)	Gaps:	40/682 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ETDDAITDSAGGE---------------QQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLE 61
            |.|.|:|:....:               :.||.|.    ....::|||:.|||...:.::|..:.
  Rat   486 EPDKAMTEDGKVDYRTEQKFADHMKEKSEASSEFA----KKKSILEQRQYLPIFAVQQELLTIIR 546

  Fly    62 KHQVVILVGETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGY 126
            .:.:||:||||||||:||:.|||::.|:...|:||.|:||||:.:::|.||::|.|..:|:.|||
  Rat   547 DNSIVIVVGETGSGKTTQLTQYLHQDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGY 611

  Fly   127 VVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRS 191
            .:||.:..|..|.||:||:||||||.|.:..|..|..||:||||||::.||::.|||::::.:||
  Rat   612 AIRFEDCTSENTLIKYMTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRS 676

  Fly   192 SLKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLH 256
            .||||::|||:||..|:.||     |.|.: ..|.||..||...:...|..|||:..|:...::|
  Rat   677 DLKLIVTSATMDADKFAAFF-----GNVPI-FHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVH 735

  Fly   257 QKEPPGDILAFLTGQEEVLEALDLLREYIASSEQEN---LKVLPMYGSMSSTDQLSVFFTPPKGT 318
            ....|||||.|:.|||::....|.:.|::  .|.||   |.|||:|..:.|..|..:|...|.|.
  Rat   736 LSGAPGDILIFMPGQEDIEVTSDQIVEHL--EELENAPALAVLPIYSQLPSDLQAKIFQKAPDGV 798

  Fly   319 RKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPG 383
            ||.::||||||||:|:.||::|||.||.|:|.:||:...|:|.|.|:|:|:|.||:|||||..||
  Rat   799 RKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPG 863

  Fly   384 KVYRLYTKSDYE-ALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLF 447
            :.:||||:|.|: .|.....||::|:.|:..:|.||:||:.::|:|.|..|||..|:|:::..|:
  Rat   864 QCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFMDPPPEDNMLNSMYQLW 928

  Fly   448 ALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVA 512
            .|.|:|..|.||. .|.|:.|.|....|||||.||..||||.||:.|:::|.|.:||.||... .
  Rat   929 ILGALDNTGGLTS-TGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKGR-E 991

  Fly   513 QQSGRIAHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQL--ITVAR 575
            ::|.:| ..||.|.|.|.:|.||.|..:.....:..:|..:|:..:.:::...:|.||  |.|.:
  Rat   992 EESDQI-REKFAVPESDHLTYLNVYLQWKNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQ 1055

  Fly   576 KKYGIPIFSCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQA-QYV 639
            :   :.:.||..|.:.:.|||.|.:|.|.|.|...|.|..|.:|....:||.|:|:.:... .|:
  Rat  1056 R---MSLASCGTDWDIVRKCICAAYFHQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYI 1117

  Fly   640 VYGELLQTTKLFMNYVTVIKREWLTELAPHYY 671
            ||.||:.|||.:|..||.:..|||.||.|.:|
  Rat  1118 VYHELVMTTKEYMQCVTAVDGEWLAELGPMFY 1149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	267/634 (42%)
		DEXDc	64..202	CDD:238005	71/137 (52%)
		HELICc	289..380	CDD:197757	48/93 (52%)
		HA2	448..534	CDD:214852	38/85 (45%)
		OB_NTP_bind	<581..670	CDD:285018	36/89 (40%)
Dhx38	XP_006255639.1	DUF3984	<190..>299	CDD:289881
		DEXDc	526..713	CDD:214692	91/192 (47%)
		DEXDc	551..687	CDD:238005	71/135 (53%)
		HELICc	758..861	CDD:197757	51/104 (49%)
		HA2	930..1012	CDD:214852	38/84 (45%)
		OB_NTP_bind	<1063..1146	CDD:285018	33/82 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720