DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and Dhx37

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001099396.2	Gene:	Dhx37 / 288647	RGDID:	1306837	Length:	1150	Species:	Rattus norvegicus

Alignment Length:	804	Identity:	263/804 - (32%)
Similarity:	381/804 - (47%)	Gaps:	197/804 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTK-GLIGI 97
            ||....:.|:|.:|||......|:..:.:|.:||:.|||||||:|||||:|||.|:.:: .:||:
  Rat   235 VNRTPEMQEERLKLPILAEEQAIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGYSSEDSIIGV 299

  Fly    98 TEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYG 162
            ||||||:.|.::.|||:|. .|....|.|.:|:..:::..|:|||||:|:||:|:..|.||.:|.
  Rat   300 TEPRRVAAVAMSQRVAKEM-NLSHRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLKYK 363

  Fly   163 VIIVDEAHERNMLTDMILGLLKKILRKRSS----LKLIISSATIDASFFSE---FFSWPGSGEVS 220
            |:|:||||||::.||::||||.:|:..|:.    |||:|.|||:....|::   .|:.|     .
  Rat   364 VVIIDEAHERSVYTDILLGLLSRIVALRAKRHLPLKLLIMSATLRVEDFTQNQRLFTTP-----P 423

  Fly   221 VKLSIEGRMHPVS-NFYLNEPCADYVKETVETVWKLHQKEPPGDILAFLTGQEEV---------- 274
            ..:.:|.|..||: :|....|..||..|....|.|:|:..|.|.||.|||||.||
  Rat   424 PVIKVESRQFPVTVHFNKRTPLDDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKA 488

  Fly   275 -----------------------------------------LEALDLL--------REYIASSEQ 290
                                                     |:...:|        ||.....|:
  Rat   489 FPIRCSQPQEMEEDSAEGMRRFKKSRTRARKAQAMALPQINLDNYSVLPAGEGDEDREAEMDDEE 553

  Fly   291 E-------------------------NLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAET 330
            |                         .|.|||:|..::...|..||..||:|||..|:|||:|||
  Rat   554 EALGSDLDLDLGDSEANEGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVIATNVAET 618

  Fly   331 SITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYE 395
            |:|||||.||:|||.||.::|:..|...|..:..||:|||.||||||||..||..||||:.:.:.
  Rat   619 SLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFG 683

  Fly   396 ALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAID------- 453
            ......|||:.|..:...|||:|||.|..::.|.||:||..:.|::|.|.|.||.|:.
  Rat   684 DFEQFPPPEITRRPVEDLILQMKALNIEKVINFPFPTPPSVEALIAAEELLIALGALQAPPKQER 748

  Fly   454 ----EQGNLTKPV---GYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIF---SRPA 508
                :...|:.|:   |..::..|.:...:|||.:|.|.||....|.|:|.:.|:.:|   .|||
  Rat   749 MKKLQMSQLSCPITALGRTMSTFPVAPRYAKMLALSQQHGCLPYTIAIVAAMTVRELFEELDRPA 813

  Fly   509 SAVAQQSGRIAHRKFEVAE--------------GDFITMLNAYTGFVEEGMTKEFCGQYFLIYRN 559
             |..::...:..|:..||:              ||.:.:|.|.......|.:.:||....|.|:.
  Rat   814 -ASEEELAELKGRRTRVAQMKRTWAGQGASLKLGDLMVLLGAVGACEYAGCSPQFCQANGLRYKA 877

  Fly   560 LKRAHSLREQLITVARKKYGIPIFSCKGDVEKLCKCITAGFF----------TQVAYLHHSGVYR 614
            :.....||.||.|...                 ..|..||.|          :||.||      |
  Rat   878 MLEIRRLRGQLTTAVN-----------------AVCPEAGLFLDPKMQPPTESQVTYL------R 919

  Fly   615 QISS---GTELA---------------------------IHPNSTLY-TLPQAQYVVYGELLQTT 648
            ||.:   |..||                           |||:|.|: .||  ::|||.|:::||
  Rat   920 QIMAAGLGDHLARRVQSEDLLDPKWKNAYKTPLLDDPVFIHPSSVLFRELP--EFVVYQEIVETT 982

  Fly   649 KLFMNYVTVIKREWLTELAPHYYQ 672
            |::|..|:.::.:|:..|.|.|.|
  Rat   983 KMYMKGVSTVEIQWIPSLLPSYCQ 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	258/792 (33%)
		DEXDc	64..202	CDD:238005	71/142 (50%)
		HELICc	289..380	CDD:197757	50/115 (43%)
		HA2	448..534	CDD:214852	28/116 (24%)
		OB_NTP_bind	<581..670	CDD:285018	33/129 (26%)
Dhx37	NP_001099396.2	HrpA	236..1009	CDD:224557	262/803 (33%)
		DEXDc	267..407	CDD:238005	71/140 (51%)
		HELICc	578..667	CDD:197757	47/88 (53%)
		HA2	730..781	CDD:282288	11/50 (22%)
		HA2	761..852	CDD:214852	23/91 (25%)
		OB_NTP_bind	887..1004	CDD:285018	36/141 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820