DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and prp22

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_593253.1	Gene:	prp22 / 2542978	PomBaseID:	SPAC10F6.02c	Length:	1168	Species:	Schizosaccharomyces pombe

Alignment Length:	681	Identity:	291/681 - (42%)
Similarity:	432/681 - (63%)	Gaps:	30/681 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KFLKPETDDA---ITDSAGGEQQSSAFVFNVNHNMG------LMEQRERLPIRQYRDQILYCLEK 62
            ||.:...|.|   :|......:|::.   |.|.:.|      :.||||.||:.:.|.|.|..:.|
pombe   464 KFAQDVRDSAARQLTSETPSWRQATR---NANISYGKRTTLSMKEQREGLPVFKLRKQFLEAVSK 525

  Fly    63 HQVVILVGETGSGKSTQVPQYLYEWGWHTKG-LIGITEPRRVSTVTLANRVAQERGELVGDTVGY 126
            :|:::|:|||||||:||:.|||.|.|:.:.. :||.|:||||:.:::|.|||:|.|..||:.|||
pombe   526 NQILVLLGETGSGKTTQITQYLAEEGYTSDSKMIGCTQPRRVAAMSVAKRVAEEVGCRVGEEVGY 590

  Fly   127 VVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRS 191
            .:||.:..|..|:||:||:|:|.||.|.||||::|.|||:||||||.:.||::.||||..:.||.
pombe   591 TIRFEDKTSRMTQIKYMTDGMLQRECLVDPLLSKYSVIILDEAHERTVATDVLFGLLKGTVLKRP 655

  Fly   192 SLKLIISSATIDASFFSE-FFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKL 255
            .||||::|||:||..||. |:..|       ..:|.||.:||...|..:|.|||:...:.||.::
pombe   656 DLKLIVTSATLDAERFSSYFYKCP-------IFTIPGRSYPVEIMYTKQPEADYLDAALMTVMQI 713

  Fly   256 HQKEPPGDILAFLTGQEEVLEALDLL--REYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGT 318
            |..|.|||||.|||||||:..:.::|  |..:.......|.:||:|.::.|..|..:|...|.|.
pombe   714 HLSEGPGDILVFLTGQEEIDTSCEILYERSKMLGDSIPELVILPVYSALPSEIQSRIFEPAPPGG 778

  Fly   319 RKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPG 383
            ||||:||||||||:||.||.||:|.|:||...::||...|||::.|:|:|.|.||:|||||..||
pombe   779 RKVVIATNIAETSLTIDGIYYVVDPGFVKQSCFDPKLGMDSLIVTPISQAQARQRSGRAGRTGPG 843

  Fly   384 KVYRLYTKSDY-EALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLF 447
            |.|||||:|.| ..:.|...||::|..||..||.|||:||.::|.|||..|||||.:::||::|:
pombe   844 KCYRLYTESAYRNEMLPSPIPEIQRQNLSHTILMLKAMGINDLLNFDFMDPPPAQTMIAALQNLY 908

  Fly   448 ALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVA 512
            ||.|:|::|.|| |:|..:|:.|....|||:|..|.::|||||:::|||:|.|.:|:|||..  .
pombe   909 ALSALDDEGLLT-PLGRKMADFPMEPQLSKVLITSVELGCSEEMLSIIAMLSVPNIWSRPRE--K 970

  Fly   513 QQSGRIAHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKK 577
            ||.......:|...|.|.:|:||.||.:.....:..:|.::::..|.::||..:|:|||.: ..:
pombe   971 QQEADRQRAQFANPESDHLTLLNVYTTWKMNRCSDNWCYEHYIQARGMRRAEDVRKQLIRL-MDR 1034

  Fly   578 YGIPIFSCKGDVEKLCKCITAGFFTQVAYL-HHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVY 641
            |..|:.||....|.:.:.:.:|:||.||.. .|.|.|:.|.....:.:||:..|:. ..|::|:|
pombe  1035 YRHPVVSCGRKRELILRALCSGYFTNVAKRDSHEGCYKTIVENAPVYMHPSGVLFG-KAAEWVIY 1098

  Fly   642 GELLQTTKLFMNYVTVIKREWLTELAPHYYQ 672
            .||:||:|.:|:.|:.:..:||.|:||.:::
pombe  1099 HELIQTSKEYMHTVSTVNPKWLVEVAPTFFK 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	280/633 (44%)
		DEXDc	64..202	CDD:238005	75/138 (54%)
		HELICc	289..380	CDD:197757	46/90 (51%)
		HA2	448..534	CDD:214852	36/85 (42%)
		OB_NTP_bind	<581..670	CDD:285018	31/89 (35%)
prp22	NP_593253.1	Pnp	1..>441	CDD:224106
		S1_DHX8_helicase	207..287	CDD:240189
		DEXDc	506..692	CDD:214692	96/192 (50%)
		DEXDc	527..666	CDD:238005	75/138 (54%)
		HELICc	737..841	CDD:197757	49/103 (48%)
		HA2	909..992	CDD:214852	36/85 (42%)
		OB_NTP_bind	1026..1125	CDD:285018	33/100 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.680