DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and prh1

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_593091.1	Gene:	prh1 / 2541750	PomBaseID:	SPAC2G11.11c	Length:	719	Species:	Schizosaccharomyces pombe

Alignment Length:	670	Identity:	263/670 - (39%)
Similarity:	410/670 - (61%)	Gaps:	18/670 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLKPETDDAITDSAGGEQQS--SAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVG 70
            ||:.:||....:..|.:..|  .....:.:....::|||:.|||.:..|.:...::.::|:::||
pombe    55 FLEQDTDFGANEVVGSDNSSPEKRSENSPSKRKDILEQRKNLPIWEAHDTLCQQIQDNRVIVVVG 119

  Fly    71 ETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMS 135
            |||||||||:||:|.|..:..:|.:.||:||||:.|.||.|||.|:|..:|:.|||.:||.::.|
pombe   120 ETGSGKSTQIPQFLNECPYAQEGCVAITQPRRVAAVNLAKRVAAEQGCRLGEQVGYSIRFDDTTS 184

  Fly   136 SCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSA 200
            ..|:||::|:|:||||::.||:|:||..:|:||||||.::|||:||.:|||::||.:|::||.||
pombe   185 KKTRIKYLTDGMLLRELINDPILSQYHTLILDEAHERTLMTDMLLGFVKKIIKKRPALRVIIMSA 249

  Fly   201 TIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQKEPPGDIL 265
            |::|..|||||.   ..|:..   |.||.:||...|...|..||:...:.|:::||.|.||||||
pombe   250 TLNAERFSEFFD---GAEICY---ISGRQYPVQIHYTYTPEPDYLDACLRTIFQLHTKLPPGDIL 308

  Fly   266 AFLTGQEEVLEALD-LLREYIAS--SEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNI 327
            .|||||:|: |||: |::.|...  |....::..|::.|:....||.||.......|||||:|||
pombe   309 VFLTGQDEI-EALEALIKSYSKQLPSNLPQIQACPLFASLPQEQQLQVFLPALANHRKVVLSTNI 372

  Fly   328 AETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKS 392
            ||||:||.||.||||.|..|:|.:|.|...:||.:.|:|:::|:||:|||||...|:.||:||::
pombe   373 AETSVTISGIRYVIDTGLAKIKQFNSKLGLESLTVQPISQSAAMQRSGRAGREAAGQCYRIYTEA 437

  Fly   393 DYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGN 457
            |::.|.....||::|.:||.|:|.|||.|..:::.|.:..||..:.||.|||.|:::.|:|:.|:
pombe   438 DFDKLPKETIPEIKRIDLSQAVLTLKARGQNDVINFHYMDPPSKEGLLRALEHLYSIGALDDNGH 502

  Fly   458 LTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRK 522
            : ..:||.::.:|....|::.:..:.:..|..|:|.:::.|...|:|..|..  .:.....|..|
pombe   503 I-NDLGYQMSLIPLLPSLARAVLAAREHNCLSEVIDVVSCLSTDSMFLFPQE--KRDEAIEARLK 564

  Fly   523 FEVAEGDFITMLNAYTGFVEEG--MTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIPIFSC 585
            |..:|||.:|.|||...::|..  ..|::|.|.|:..|.||....:|:||.....|.......|.
pombe   565 FLHSEGDLLTCLNALRQYLESSHDSRKQWCSQNFINRRALKTILDIRKQLREHCLKDGWELNSSP 629

  Fly   586 KGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYGELLQTTKL 650
            :.:.|.|.....:|:.|..|.||..|.||.|.....::|||:|:|:. .:.:.::|.||:.|||.
pombe   630 EVNSENLLLSFLSGYITNTALLHPDGSYRTIIGNQTISIHPSSSLFG-KKVEAIMYHELVFTTKS 693

  Fly   651 FMNYVTVIKREWLTELAPHY 670
            ::..|:.|:..||..:||||
pombe   694 YVRGVSSIRSNWLNAVAPHY 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	253/632 (40%)
		DEXDc	64..202	CDD:238005	74/137 (54%)
		HELICc	289..380	CDD:197757	42/90 (47%)
		HA2	448..534	CDD:214852	21/85 (25%)
		OB_NTP_bind	<581..670	CDD:285018	29/88 (33%)
prh1	NP_593091.1	HrpA	58..711	CDD:224557	257/663 (39%)
		DEXDc	113..251	CDD:238005	74/137 (54%)
		HELICc	276..433	CDD:238034	71/157 (45%)
		HA2	493..576	CDD:214852	21/85 (25%)
		OB_NTP_bind	601..713	CDD:285018	36/112 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810