Protein Alignment CG3225 and Ythdc2

DIOPT Version :10

• Sequence 1: NP_608860.1
• Gene: CG3225 / 33680
• FlyBaseID: FBgn0031631
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001156485.1
• Gene: Ythdc2 / 240255
• MGIID: 2448561
• Length: 1445
• Species: Mus musculus
• Alignment Length: 858
• Identity: 223/858 - (25%)
• Similarity: 345/858 - (40%)
• Gaps: 267/858 - (31%)

  Fly    23 GEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEW 87
            ||.:..:|             |:.||:.:.:::|:..:::::||::||||||||:||:||:|.:
Mouse   197 GESEFDSF-------------RQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLD- 247

  Fly    88 GWHTKGL---IGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILL 149
            .....|:   |..|:|||::.:.:|.|||.||.|.:|.|:||.:|....:|..|.:.|.|.|:||
Mouse   248 DCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLL 312

  Fly   150 REVLA-DPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSW 213
            |.::| |..|:....:||||.|||:..:|.:|..|:.:|:|..:||||:|||.:|.:.|..:|
Mouse   313 RTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYF-- 375

  Fly   214 PGSGEVSVKLSIEGRMHPVSNFYL----------NEPCADYVKE--------TVETVW------- 253
             ||..|   :.|:||...|...:|          |:....|.||        |..|.|
Mouse   376 -GSCPV---IYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENT 436

  Fly   254 ------------------------------KLHQK-----EP---------------PGDILAF- 267
                                          :|.:|     ||               ..|:.||
Mouse   437 FKPESQRQRAVASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFA 501

  Fly   268 --------------------------------LTGQEEVL------------------------- 275
                                            .|.|.|.|
Mouse   502 QVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFG 566

  Fly   276 --EALDLLREYIASSEQENL--------------------------------------------- 293
              |.:|||..|.||.|..||
Mouse   567 QTEIVDLLESYSASLEFGNLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNI 631

  Fly   294 ----------------------------------------KVLPMYGSMSSTDQLSVFFTPPKGT 318
                                                    :|..::.:|.::||..|...||.|.
Mouse   632 CHSCDAGAILIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGV 696

  Fly   319 RKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPG 383
            ||::|:|||||||||:..:|:|||.|.||.|.::.......|.:|.:||||||||.|||||.|||
Mouse   697 RKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPG 761

  Fly   384 KVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDF----PSPPPAQNLLSALE 444
            ..:||:::..::.:...|.||:.|..|....|..|.|...|....||    |.||||..:.:|::
Mouse   762 ICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPPALIVRNAVQ 826

  Fly   445 SLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPAS 509
            .|..:||:|...:||: :||.||:||....|.||:..:..:.|.:.|:||...|..:..|..|..
Mouse   827 MLKTIDAMDAWEDLTE-LGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQ 890

  Fly   510 AVAQQSGRIAHRKFEVAE-GDFITMLNAYTGFVE---EGMTKEFCGQYFLIYRNLKRAHSLREQL 570
            |..:::..:..::|.... .|.:.:|.|:..:.:   :|..:.||.:.||....::....:|.||
Mouse   891 ASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQL 955

  Fly   571 ITVARKKYGIPIFSCKGDVEK----------LCKCITAGFFTQVAYLHHSGVYRQISSGTELAIH 625
            :...|.. |.......||:..          :...:.||.:..:.::....|........::..|
Mouse   956 LGQLRAS-GFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENVILTGPKEKKVRFH 1019

  Fly   626 PNSTLYTLPQAQY 638
            |.|   .|.|.||
Mouse  1020 PTS---VLSQPQY 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	38..>669	CDD:441249	220/843 (26%)
Ythdc2	NP_001156485.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50
		R3H_DEXH_helicase	61..119	CDD:100077
		PRK11131	203..>1033	CDD:182986	221/852 (26%)
		DEXHc_YTHDC2	208..383	CDD:350745	72/181 (40%)
		DEAH box	331..334		2/2 (100%)
		ANK repeat	520..552	CDD:293786	4/31 (13%)
		ANK 1	521..553		4/31 (13%)
		ANK 2	554..586		8/31 (26%)
		ANK repeat	554..582	CDD:293786	7/27 (26%)
		SF2_C_RHA	612..767	CDD:350178	47/154 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1179..1303
		YTH	1304..1433	CDD:410979