DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and DHX30

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_011531792.1	Gene:	DHX30 / 22907	HGNCID:	16716	Length:	1265	Species:	Homo sapiens

Alignment Length:	685	Identity:	208/685 - (30%)
Similarity:	320/685 - (46%)	Gaps:	100/685 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 EQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGL-----IGITEPR 101
            ::..:||:..:||.||..:|:|.||::.|:||.||:|::||.|.| .:.|:|.     :.||:||
Human   500 QEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLE-RYVTEGRGARCNVIITQPR 563

  Fly   102 RVSTVTLANRVAQERGELVGDTVGYVVRFLESM--SSCTKIKFMTEGILLREVLADPLLTQYGVI 164
            |:|.|::|.||:.|.|..:...||:.|| |||.  |....:.|.|.|||||::.::|.|.....:
Human   564 RISAVSVAQRVSHELGPSLRRNVGFQVR-LESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHV 627

  Fly   165 IVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRM 229
            ||||.|||::.||.:|.|||.:.|...:|:|::.|||.|...||.:|     |...| :.:.|.|
Human   628 IVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYF-----GGCPV-IKVPGFM 686

  Fly   230 HPVSNFYL---------------------NEPCADYVKETVETVWKLHQKEPPGDILAFLTGQEE 273
            :||...||                     .:.||..:....:.|..:..:..||.||.||.|.:|
Human   687 YPVKEHYLEDILAKLGKHQYLHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQE 751

  Fly   274 VLEALDLLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIV 338
            :......|:|.:...|.:.| :||::.::...||.::|..||.|.||:|||||||||||||..||
Human   752 IKGVQQRLQEALGMHESKYL-ILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIV 815

  Fly   339 YVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPP 403
            :|:|.|..|.:.|:.||....|..|.||:|:.|||.|||||.:.|..|.|:.:|..|.:.|.|.|
Human   816 HVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVP 880

  Fly   404 EMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYL--- 465
            |:.|:.|...:||.|         ...|.....:.|..|::|. .:.|:||...|.:.:|.|
Human   881 EILRTPLENLVLQAK---------IHMPEKTAVEFLSKAVDSP-NIKAVDEAVILLQEIGVLDQR 935

  Fly   466 ---------LAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHR 521
                     ||.:.....|:|.:.::....|...::.:::.|.     ..|.|:..|....:...
Human   936 EYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-----RDPFSSSLQNRAEVDKV 995

  Fly   522 KFEVAE---GDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIPIF 583
            |..::.   .|.:..:.|..|:.|....::...:...:..||..|.|||  .|....|::...|:
Human   996 KALLSHDSGSDHLAFVRAVAGWEEVLRWQDRSSRENYLEENLLYAPSLR--FIHGLIKQFSENIY 1058

  Fly   584 ----------------SCK--GDVEKLCK-CITAGFFTQVAYLHHSGVYRQISSGTELAIHPNST 629
                            .|.  .:.|:|.| .:.||.:..:..:....|.||..      ..|||.
Human  1059 EAFLVGKPSDCTLASAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGK------FKPNSV 1117

  Fly   630 LYTLPQAQYVVYGELLQTTKLFMNYVTVIKREWLT 664
            .|....      |.:|..........|.::..|||
Human  1118 TYRTKS------GNILLHKSTINREATRLRSRWLT 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	208/685 (30%)
		DEXDc	64..202	CDD:238005	61/144 (42%)
		HELICc	289..380	CDD:197757	46/90 (51%)
		HA2	448..534	CDD:214852	17/100 (17%)
		OB_NTP_bind	<581..670	CDD:285018	20/103 (19%)
DHX30	XP_011531792.1	HrpA	494..>1143	CDD:224557	205/680 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810