DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and Dhx8

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_659080.2	Gene:	Dhx8 / 217207	MGIID:	1306823	Length:	1244	Species:	Mus musculus

Alignment Length:	656	Identity:	285/656 - (43%)
Similarity:	422/656 - (64%)	Gaps:	22/656 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYE 86
            ||.:.|    :.....|.::||||.|||.:.::|::..:..:|::|::|||||||:||:.|||.|
Mouse   568 GGNKAS----YGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAE 628

  Fly    87 WGWHTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLRE 151
            .|:.::|.||.|:||||:.:::|.||::|.|..:|..|||.:||.:..|..|.||:||:|:||||
Mouse   629 AGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRE 693

  Fly   152 VLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGS 216
            .|.||.||||.:|::||||||.:.||::.|||||.::||..:|||::|||:||..||::|.
Mouse   694 CLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFY---- 754

  Fly   217 GEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQKEPPGDILAFLTGQEEVLEALDLL 281
             |..: .:|.||.:||...|..||..||:..::.||.::|..|||||||.|||||||:..|.::|
Mouse   755 -EAPI-FTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEIL 817

  Fly   282 REYIAS--SEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCG 344
            .|.:.|  .:...|.:||:|.::.|..|..:|...|.|:||||:||||||||:||.||.||:|.|
Mouse   818 YERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPG 882

  Fly   345 YVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDY-EALAPRQPPEMRRS 408
            :||.|.||.||..|.||:.|:|:|.|.||||||||..|||.|||||:..| :.:.....||::|:
Mouse   883 FVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRT 947

  Fly   409 ELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSA 473
            .|:..:|.|||:||.::|.|||...||.:.|::|:|.|:.|.|:|::|.||: :|..:||.|...
Mouse   948 NLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTR-LGRRMAEFPLEP 1011

  Fly   474 MLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRP--ASAVAQQSGRIAHRKFEVAEGDFITMLNA 536
            ||.|||.:|..:|||||::||:::|.||::|.||  ..|:|.|.    ..||...|||.:|:|..
Mouse  1012 MLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQK----KAKFHQTEGDHLTLLAV 1072

  Fly   537 YTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIPIFSCKGDVEKLCKCITAGFF 601
            |..:.....:..:|.:.|:..|:|:||..:|:|::.: ..::.:.:.||.....::.|.|.:|||
Mouse  1073 YNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGI-MDRHKLDVVSCGKSTVRVQKAICSGFF 1136

  Fly   602 TQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYGELLQTTKLFMNYVTVIKREWLTEL 666
            ...|.......||.:.....:.|||:|.|:. .|.::|||.||:.|||.:|..||.|...||.|.
Mouse  1137 RNAAKKDPQEGYRTLIDQQVVYIHPSSALFN-RQPEWVVYHELVLTTKEYMREVTTIDPRWLVEF 1200

  Fly   667 APHYYQ 672
            ||.:::
Mouse  1201 APAFFK 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	279/632 (44%)
		DEXDc	64..202	CDD:238005	74/137 (54%)
		HELICc	289..380	CDD:197757	50/90 (56%)
		HA2	448..534	CDD:214852	38/87 (44%)
		OB_NTP_bind	<581..670	CDD:285018	33/88 (38%)
Dhx8	NP_659080.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..289
		S1_DHX8_helicase	289..367	CDD:240189
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..396
		DEXDc	585..770	CDD:214692	93/190 (49%)
		DEXDc	606..744	CDD:238005	74/137 (54%)
		DEAH box	709..712		2/2 (100%)
		HELICc	769..926	CDD:238034	81/156 (52%)
		HA2	988..1070	CDD:214852	38/86 (44%)
		OB_NTP_bind	1104..1203	CDD:285018	33/100 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730