DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and rha-2

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_498895.1	Gene:	rha-2 / 176207	WormBaseID:	WBGene00015525	Length:	1148	Species:	Caenorhabditis elegans

Alignment Length:	823	Identity:	230/823 - (27%)
Similarity:	361/823 - (43%)	Gaps:	180/823 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PETD-DAITDSAGGEQQS---------SAFVFN-----VNHNMGLMEQRERLPIRQYRDQILYCL 60
            |||: |.|......:::|         :..|.|     |..:..:.:.|..|||.....:|:..:
Worm   185 PETNLDQIVVKREDDEESDNEDILALPTTTVINRKKVIVERSKEIQKSRAELPIFAEEMRIVEAI 249

  Fly    61 EKHQVVILVGETGSGKSTQVPQYLYEWGWHTKG-LIGITEPRRVSTVTLANRVAQERGELVGDTV 124
            .::.|.::.|||||||:||:||:|||.|:.::| ||||||||||:.:.:|.||..|..:  .|.|
Worm   250 NENLVTVVCGETGSGKTTQIPQFLYEAGYASEGELIGITEPRRVAAIAMAQRVGVELAK--PDEV 312

  Fly   125 GYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRK 189
            .|.:|:..:.|..|.|.|||:|:|::|:..|.:|.:|.||::||||||:|.:|:::|:|.:|:..
Worm   313 SYQIRYEGTRSETTNILFMTDGVLMKEMEQDVMLKKYSVILIDEAHERSMYSDVLIGMLSRIVPL 377

  Fly   190 RSS----LKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVE 250
            ||.    |:|:|.|||:....|:....:|......:|  ::.|..|||..:......||:.....
Worm   378 RSKTARPLRLVIMSATLRLDDFTHKKLFPLLTPKVIK--VDARQFPVSVHFEKRTPDDYIASAFR 440

  Fly   251 TVWKLHQKEPPGDILAFLTGQEEV----------------------------------------- 274
            ...::|:..|||.||.|:|||.||
Worm   441 KTCRIHETLPPGAILVFVTGQHEVKQLITKLKKRYPVVYETDKNGEVLVKGTKEWKEKKVEAAKS 505

  Fly   275 ----------------------------------LEALDLLREY------IASSEQEN------- 292
                                              .||.|...|:      ::..:.||
Worm   506 IKLEDFKEETPETEDFEDVDDGLMDGDDMNERGAAEAFDDYEEFENGDGDLSDGKVENSIGAPPA 570

  Fly   293 ----LKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNP 353
                |..||:|..:|...|..||...|.|.|..|::||:||||:||||:.||||.|:.|.:.|:.
Worm   571 DCEPLYCLPLYSLLSMGKQRRVFDETPAGMRLCVISTNVAETSLTIPGVKYVIDGGFEKRRLYDS 635

  Fly   354 KTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLK 418
            .|......:..:|:||..||||||||:..|..||||:.:.|:.......||:........:|.||
Worm   636 ITGVSRFAVCRISQASGDQRAGRAGRISAGHAYRLYSSAVYQDFVKFADPEILSKPADQLVLHLK 700

  Fly   419 ALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDE-------QGNLTKPVGYLLAELPFSAMLS 476
            ::.|..::.|.|||.|..|.|.||.:.|..|.|:.|       :..:|| :|..||..|.:...:
Worm   701 SMNIVKVVNFPFPSAPDEQMLESAEKRLCRLGALSESTKNGKTEARITK-LGKTLAVFPLAPSYA 764

  Fly   477 KMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAE-------------- 527
            |.:.::.|.......|.:|:||.|:    .|...|:...|.......|:.:
Worm   765 KFIAMADQHNLMSHAILLISLLSVR----EPLIPVSSLRGDTPEETKELMKNVLKERRRWCSHTG 825

  Fly   528 ----GDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIPIFSCKGD 588
                ||...:::|.:...:.......|.:..|..:.|..|..||:||..:...       |||.:
Worm   826 ARRLGDLKVLMHAASVAEQIKYNARECEKVGLRVKALVEARKLRQQLTNIVNA-------SCKKE 883

  Fly   589 ----------------VEKLCKCITAGFFTQVA-YLHHSGVYRQISSGT--------ELAIHPNS 628
                            .:.|.:.:.|.|..::| .:..|....::..|.        .:.|.|.|
Worm   884 HAAALDSDLPPPTDQQAQLLRQMVVASFSDRLARRVDRSVGQEEVQKGAYETTLIKGHVFIDPCS 948

  Fly   629 TLYTLPQAQYVVYGELLQTT-KLFMNYVTVIKREWLTELAPHY 670
            .::| .:.::|:|.||:|.. |..|..|..:.:|||:.||..|
Worm   949 VVFT-EEPEFVIYQELVQVNEKKLMTSVCAVDKEWLSRLAESY 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	219/775 (28%)
		DEXDc	64..202	CDD:238005	67/142 (47%)
		HELICc	289..380	CDD:197757	42/101 (42%)
		HA2	448..534	CDD:214852	22/110 (20%)
		OB_NTP_bind	<581..670	CDD:285018	26/114 (23%)
rha-2	NP_498895.1	HrpA	218..989	CDD:224557	221/787 (28%)
		DEXDc	254..394	CDD:238005	67/141 (48%)
		P-loop_NTPase	<350..>477	CDD:304359	42/128 (33%)
		HELICc	577..662	CDD:197757	39/84 (46%)
		HA2	730..822	CDD:214852	20/96 (21%)
		OB_NTP_bind	870..990	CDD:285018	28/127 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820