DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and ddx-15

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_741147.1	Gene:	ddx-15 / 175771	WormBaseID:	WBGene00018967	Length:	739	Species:	Caenorhabditis elegans

Alignment Length:	662	Identity:	262/662 - (39%)
Similarity:	397/662 - (59%)	Gaps:	40/662 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEW-GWHTKG----- 93
            |....:.|:|.:||:.:|:::.:..|..:|.:.|||||||||:||:||:..|: ....:|
Worm    64 NRYWAIWEKRSQLPVWEYKEKFMELLRNNQCITLVGETGSGKTTQIPQWAVEFMKQQQQGQPPGQ 128

  Fly    94 --LIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADP 156
              |:..|:||||:.:::|.|||:|...::|..|||.:||.:.:|..|.:|:.|:|:||||.:..|
Worm   129 ARLVACTQPRRVAAMSVATRVAEEMDVVLGQEVGYSIRFEDCISERTVLKYCTDGMLLREAMNSP 193

  Fly   157 LLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSV 221
            ||.:|.|:|:||||||.:.||:::||:|:|:|.|:.:|::|.|||:||..|..:|      |...
Worm   194 LLDKYKVLILDEAHERTLATDILMGLIKEIVRNRADIKVVIMSATLDAGKFQRYF------EDCP 252

  Fly   222 KLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQ-KEPPGDILAFLTGQEEVLEALDLL-REY 284
            .||:.||..||..|:......||::..:.||.::|. :|..||||.|||||||:.||...: ||.
Worm   253 LLSVPGRTFPVEIFFTPNAEKDYLEAAIRTVIQIHMVEEVEGDILLFLTGQEEIEEACKRIDREI 317

  Fly   285 IA-SSEQENLKVLPMYGSMSSTDQLSVFFTPPKG------TRKVVLATNIAETSITIPGIVYVID 342
            .| .::...|..:|:|.::....|..:|...|..      :||.|::|||||||:||.|:|:|||
Worm   318 QALGADAGALSCIPLYSTLPPAAQQRIFEPAPPNRPNGAISRKCVISTNIAETSLTIDGVVFVID 382

  Fly   343 CGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDY-EALAPRQPPEMR 406
            .|:.|.|.|||:...:||::.|:|||||:||||||||.:|||.:||||::.| ..:..:..||:.
Worm   383 PGFSKQKVYNPRIRVESLLVCPISKASAMQRAGRAGRTKPGKCFRLYTETAYGSEMQDQTYPEIL 447

  Fly   407 RSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPF 471
            ||.|...:||||.||..:::.|||..||..:.|:.|||.|..|.||::.|.||: :|.|:||.|.
Worm   448 RSNLGSVVLQLKKLGTEDLVHFDFMDPPAPETLMRALELLNYLQAINDDGELTE-LGSLMAEFPL 511

  Fly   472 SAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRP---ASAVAQQSGRIAHRKFEVAEGDFITM 533
            ...|:|||..|.::.||.||::|.|:|.|...:.||   .:...:...|.||     .:||.:|:
Worm   512 DPQLAKMLITSTELNCSNEILSITAMLSVPQCWVRPNEMRTEADEAKARFAH-----IDGDHLTL 571

  Fly   534 LNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGI----PIFSCKGDVEKLCK 594
            ||.|..|.:.....::|...|:.||.:|.|.::|.||..| ..||.:    ..|..:.....:.|
Worm   572 LNVYHSFKQNQEDPQWCYDNFINYRTMKTADTVRTQLSRV-MDKYNLRRVSTDFKSRDYYLNIRK 635

  Fly   595 CITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYGELLQTTKLFMNYVTVIK 659
            .:.||||.|||:|..||.|..:.....:.:||::.|...|  ::.:|.|.:.|||.|:..||.::
Worm   636 ALVAGFFMQVAHLERSGHYVTVKDNQLVNLHPSTVLDHKP--EWALYNEFVLTTKNFIRTVTDVR 698

  Fly   660 REWLTELAPHYY 671
            .|||.::||.||
Worm   699 PEWLLQIAPQYY 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	257/652 (39%)
		DEXDc	64..202	CDD:238005	66/145 (46%)
		HELICc	289..380	CDD:197757	44/96 (46%)
		HA2	448..534	CDD:214852	32/88 (36%)
		OB_NTP_bind	<581..670	CDD:285018	30/88 (34%)
ddx-15	NP_741147.1	Motor_domain	41..>106	CDD:277568	16/41 (39%)
		DEXDc	70..266	CDD:214692	84/201 (42%)
		DEXDc	95..239	CDD:238005	65/143 (45%)
		HELICc	327..419	CDD:197757	43/91 (47%)
		HA2	489..572	CDD:214852	32/88 (36%)
		OB_NTP_bind	607..709	CDD:285018	35/104 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830