DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and ddx-35

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_497420.1	Gene:	ddx-35 / 175308	WormBaseID:	WBGene00022056	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	677	Identity:	304/677 - (44%)
Similarity:	447/677 - (66%)	Gaps:	29/677 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DDAITDSAGG----EQQSSAFVFNVNHN----MGLMEQRERLPIRQYRDQILYCLEKHQVVILVG 70
            ::..|::||.    |:|     ..|::|    :.:.:||.||||.:.|..|||..|:::.:|:||
Worm    41 EERSTENAGAAPPIEEQ-----LKVHNNPYASLNIQQQRIRLPIFKNRGHILYMCERYRTIIIVG 100

  Fly    71 ETGSGKSTQVPQYLYEWGWHTKG-LIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESM 134
            |||.||||||||:|.|.||...| .|.||:||||:.||||.|||:|:..::|..|||.|||.:..
Worm   101 ETGCGKSTQVPQFLLEAGWAADGRQIVITQPRRVAVVTLATRVAEEKDCILGHDVGYTVRFDDVS 165

  Fly   135 SSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISS 199
            ...||:||||:|:||||:||||||::|.:|::||||||:..||::||||:||::.|:.|::|:||
Worm   166 DKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSS 230

  Fly   200 ATIDASFFSEFFSWPGSG----EVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQKEP 260
            ||:||..|.:||....:|    :.:..:|:|||.|||:..:......||.:..|:||..:|:.|.
Worm   231 ATLDAELFKDFFEMNETGNSDKDTAGIISVEGRTHPVAVHHTKTSVPDYCQSAVDTVINIHKHEN 295

  Fly   261 PGDILAFLTGQEEVLEALDLLREYIASSEQ-ENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLA 324
            |||||.|||||:||.:..:.|||...:.:. :.|.|:|.||::.:.:|:..|.:.|.||||||:|
Worm   296 PGDILVFLTGQDEVEDVCEKLRELAGNLKNCDRLWVVPCYGALPAREQMKAFDSTPHGTRKVVVA 360

  Fly   325 TNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLY 389
            |||||.|||||||.||||.||||::..:.....::|:.|.||||||.||||||||:||||.||||
Worm   361 TNIAEASITIPGICYVIDTGYVKLRAQHAANGVETLMRVTVSKASAEQRAGRAGRIRPGKCYRLY 425

  Fly   390 TKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDE 454
            .:|::|..|....||::|.:::..||||||||:.|:.||.:.||||:..:::.||.|:||.||||
Worm   426 PESEFERFAEGTVPEIQRCQMASTILQLKALGVQNVHRFHYLSPPPSWAMINGLELLYALGAIDE 490

  Fly   455 QGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIA 519
            ...||.|:|..:||.|...|.||.|..|.:.|||.|::||:|::|:|.:|..|..  .:....:.
Worm   491 TSQLTSPLGLQMAEFPLPPMHSKCLLKSAEFGCSTEMVTIVAMMQIQDVFITPYR--QRHQADVI 553

  Fly   520 HRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIPIFS 584
            .:||.|.|||.:||||.:|.|||.|.:|::|..:|:.||.|.||.::|.||:.:. |::.|...|
Worm   554 RKKFAVEEGDHMTMLNVFTKFVENGRSKKWCSDHFVNYRGLMRADNVRSQLVRLL-KRFEIEKVS 617

  Fly   585 CKGDV---EKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNST-LYTLPQAQYVVYGELL 645
            .:|.:   |.:.:|:..|||:|.|..|::|.|..:.......::..|: ::.....::|::.|::
Worm   618 SRGLINCSENIRQCLVTGFFSQAAQYHYTGKYMTVKESFPFNMYKGSSIMFKKDYPKWVIFTEVM 682

  Fly   646 QTTKLFMNYVTVIKREWLTELAPHYYQ 672
            |.:   :..||||:.|||.|||||||:
Worm   683 QDS---IRDVTVIEPEWLYELAPHYYE 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	292/637 (46%)
		DEXDc	64..202	CDD:238005	80/138 (58%)
		HELICc	289..380	CDD:197757	50/91 (55%)
		HA2	448..534	CDD:214852	36/85 (42%)
		OB_NTP_bind	<581..670	CDD:285018	27/92 (29%)
ddx-35	NP_497420.1	HrpA	70..702	CDD:224557	292/637 (46%)
		DEXDc	96..233	CDD:238005	80/136 (59%)
		Helicase_C	284..416	CDD:278689	70/131 (53%)
		HA2	484..568	CDD:214852	36/85 (42%)
		OB_NTP_bind	602..704	CDD:285018	31/105 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156494
Domainoid	1	1.000	169	1.000	Domainoid score	I2296
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6406
Inparanoid	1	1.050	562	1.000	Inparanoid score	I591
Isobase	1	0.950	-	0.864974	Normalized mean entropy	S807
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D189127at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto18189
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2486
SonicParanoid	1	1.000	-	-		X4895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750