DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and mog-4

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_497027.1	Gene:	mog-4 / 175117	WormBaseID:	WBGene00003392	Length:	1008	Species:	Caenorhabditis elegans

Alignment Length:	676	Identity:	283/676 - (41%)
Similarity:	413/676 - (61%)	Gaps:	33/676 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PETDDAITDSAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSG 75
            |.|::.:.::...:::           |.:.|.|:.||:..:||..:..:::|||:|:.||||||
Worm   339 PGTNEEVVETEAEKKK-----------MSIEETRKSLPVYAFRDAFIEAVKEHQVLIIEGETGSG 392

  Fly    76 KSTQVPQYLYEWGWHTKG-LIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTK 139
            |:||:||||||.|:...| .||.|:||||:.:::|.|||.|.|..:|..|||.:||.:..|..|.
Worm   393 KTTQLPQYLYEAGFCEGGKRIGCTQPRRVAAMSVAARVADEVGCKLGTQVGYSIRFEDCTSEKTV 457

  Fly   140 IKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDA 204
            :|:||:|:||||.|.:|.|..|.|:::||||||.:.||::.||:|.|.|.|..|||:|||||:||
Worm   458 LKYMTDGMLLREFLNEPDLASYSVMMIDEAHERTLHTDILFGLVKDIARFRKDLKLLISSATLDA 522

  Fly   205 SFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQKEP-PGDILAFL 268
            ..||.||      :.:....|.||..||..:|...|.||||...:.|:.::|..:| |||||.||
Worm   523 EKFSSFF------DDAPIFRIPGRRFPVDIYYTQAPEADYVDAAIVTIMQIHLTQPLPGDILVFL 581

  Fly   269 TGQEE---VLEALDLLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAET 330
            |||||   |.||| :.|.....|:.:.|..||:|.::.|..|..:|...||..||||||||||||
Worm   582 TGQEEIETVQEAL-MERSKALGSKIKELIPLPVYANLPSDLQAKIFEPTPKDARKVVLATNIAET 645

  Fly   331 SITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYE 395
            |:||.||.||||.|:.|...::.::..:.|.:|.:|||:|.||||||||..|||.:||||...|:
Worm   646 SVTIDGINYVIDPGFSKQNSFDARSGVEHLHVVTISKAAANQRAGRAGRTGPGKCFRLYTAWAYK 710

  Fly   396 ALAPRQP-PEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLT 459
            .....|| ||::|:.|...:|.||:|||.:::.|||..|||.:.|:.|||.|:||.|::.:|.||
Worm   711 HELEEQPIPEIQRTNLGNVVLMLKSLGIHDLVHFDFLDPPPQETLVIALEQLYALGALNHRGELT 775

  Fly   460 KPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQ-SIFSRPASAVAQQSGRIAHRKF 523
            | :|..:||.|....:|||:..|.:..|||||:||.|:|... ::|.||.:.|.....  |.:.|
Worm   776 K-LGRRMAEFPCDPCMSKMIIASEKYECSEEIVTIAAMLSCNAAVFYRPKAQVIHADS--ARKGF 837

  Fly   524 EVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIPI-FSCKG 587
            ....||.||::|.|..:.|...::.:|.:.::.:|.:|||..:|:||:.:..:   :.| .....
Worm   838 WSPAGDHITLMNVYNKWQESSFSQRWCVENYVQHRTMKRARDVRDQLVGLLER---VEIETKSST 899

  Fly   588 DVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYGELLQTTKLFM 652
            |..|:.|.||||:|..|:.|.::|.|:.:........||||.|:. ...::|||.||:.|:|.||
Worm   900 DTIKIRKAITAGYFYNVSKLDNTGHYKTVKHKHTTHPHPNSCLFE-ETPRWVVYFELVFTSKEFM 963

  Fly   653 NYVTVIKREWLTELAPHYYQQTTVRD 678
            ..::.|:..||.|:|||||:...:.|
Worm   964 REMSEIESGWLLEVAPHYYKGRELED 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	274/635 (43%)
		DEXDc	64..202	CDD:238005	75/138 (54%)
		HELICc	289..380	CDD:197757	45/90 (50%)
		HA2	448..534	CDD:214852	34/86 (40%)
		OB_NTP_bind	<581..670	CDD:285018	33/89 (37%)
mog-4	NP_497027.1	DTHCT	<103..162	CDD:285332
		DEXDc	370..546	CDD:214692	90/181 (50%)
		DEXDc	381..520	CDD:238005	75/138 (54%)
		Helicase_C	577..696	CDD:278689	61/119 (51%)
		HA2	764..848	CDD:214852	34/86 (40%)
		OB_NTP_bind	872..981	CDD:285018	40/112 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830