DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3225 and rha-1

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_495890.2	Gene:	rha-1 / 174417	WormBaseID:	WBGene00004355	Length:	1301	Species:	Caenorhabditis elegans

Alignment Length:	698	Identity:	208/698 - (29%)
Similarity:	327/698 - (46%)	Gaps:	138/698 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 QRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYE-WGWHTKGL---IGITEPRRV 103
            ||..||:.|||:.|:..:.:::|.::.||||.||||||.|:|.| :..::.|.   ..:::|||:
Worm   377 QRGELPVAQYRENIVQTVAENRVTLIKGETGCGKSTQVAQFLLESFLENSNGASFNAVVSQPRRI 441

  Fly   104 STVTLANRVAQERGELVGDTVGYVVRFLESMSSCT-----KIKFMTEGILLREVLADPLLTQYGV 163
            |.::||.|||.||||.||:|.||.|||    .|.|     .|.|.|.|:|||  :.:..|.....
Worm   442 SAISLAERVANERGEEVGETCGYNVRF----DSATPRPYGSIMFCTVGVLLR--MMENGLRGISH 500

  Fly   164 IIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFF-SWPGSGEVSVKLSIEG 227
            :|:||.|||::.||.:|.:|::::.....|::::.|||||...|:.|| |.|..|...| :::.|
Worm   501 VIIDEIHERDVDTDFVLIVLREMISTYRDLRVVLMSATIDTDLFTNFFSSIPDVGPTPV-ITMHG 564

  Fly   228 RMHPVSNFYLNE----------------------PCAD---------------------YVKETV 249
            |..||.:|||.:                      |..|                     .:.|::
Worm   565 RTFPVQSFYLEDILHNLQHMPEEPDQKKRKKGGPPPPDDDEGDEEVDDKGRNMNILTDPSINESL 629

  Fly   250 ETVW-KLHQKEPP-----------------GDILAFLTGQEEVLEALDLLREYIASSEQENLKVL 296
            :|.. ::.:|:.|                 |.:|.||.|..|::...:.|.|:....:....::|
Worm   630 KTAMSRISEKDIPFGVIEAILNDIASRGVDGAVLVFLPGWAEIMTLCNRLLEHQEFGQANKYEIL 694

  Fly   297 PMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLV 361
            |::..::|.:|..||...| |.||::::||||||||||..:|||||....|.:.|..........
Worm   695 PLHSQLTSQEQRKVFNHYP-GKRKIIVSTNIAETSITIDDVVYVIDSCKAKERMYTSNNNMVHFA 758

  Fly   362 IVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNIL 426
            .|..||.:.|||.|||||:|.|..:.|.:|..:|||......||.|..|....|.:|.|.:|::.
Worm   759 TVWASKTNVIQRRGRAGRVRAGYAFHLCSKMRFEALDDHGTAEMLRIPLHQIALTIKLLRLGSVG 823

  Fly   427 RF--DFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSE 489
            .|  ....|||...::.:...|.|:.|:|....||. :|.:||.:|...:::|:|.:...:|...
Worm   824 EFLGKALQPPPYDMVVESEAVLQAMGALDRNLELTS-LGKMLARMPIEPVIAKVLILGTALGAGS 887

  Fly   490 EIITIIALLQVQSIFSRPASAVAQQ------SG---RIAHRKF--EVAEGDFITMLNAYTGFVEE 543
                  .:..|.|..|.|...|.::      ||   :.|..||  .||   .::::..|...|:.
Worm   888 ------VMCDVASAMSFPTPFVPREKHHSRLSGTQRKFAGNKFSDHVA---IVSVIQGYREAVQM 943

  Fly   544 GMT---KEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIP---IFSCKGDVEKLCKCITAGFFT 602
            |.:   :|||.:|.|....||.....|.|||.|.|.:...|   :|....:|
Worm   944 GASAAEREFCERYSLSNPVLKMTDGARRQLIDVLRNQCSFPEDILFDISVNV------------- 995

  Fly   603 QVAYLHHSGVYRQIS---SGTELAIHPNSTLY-------TLPQAQYVV 640
                   :|..|:::   |...:|::||...|       |:.|:..::
Worm   996 -------NGPDRELNLMRSLLVMALYPNVAYYVGKRKVLTIEQSSALI 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	208/698 (30%)
		DEXDc	64..202	CDD:238005	59/146 (40%)
		HELICc	289..380	CDD:197757	37/90 (41%)
		HA2	448..534	CDD:214852	24/96 (25%)
		OB_NTP_bind	<581..670	CDD:285018	12/73 (16%)
rha-1	NP_495890.2	DSRM	6..71	CDD:214634
		DSRM	173..243	CDD:214634
		HrpA	337..>974	CDD:224557	192/614 (31%)
		DEXDc	398..539	CDD:238005	59/146 (40%)
		Helicase_C	649..739	CDD:278689	31/90 (34%)
		HA2	847..931	CDD:214852	24/93 (26%)
		OB_NTP_bind	971..1086	CDD:285018	17/86 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810