DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3225 and mog-5

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_495019.1	Gene:	mog-5 / 173920	WormBaseID:	WBGene00003393	Length:	1200	Species:	Caenorhabditis elegans

Alignment Length:	670	Identity:	290/670 - (43%)
Similarity:	423/670 - (63%)	Gaps:	26/670 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PKFLKPETDDAITDSAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVG 70
            |::||..|       |||:.     .:....|:.::||||.|||...:..::..:..:|::::||
Worm   511 PEWLKHVT-------AGGKA-----TYGRRTNLSMVEQRESLPIFALKKNLMEAMIDNQILVVVG 563

  Fly    71 ETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMS 135
            ||||||:||:.||..|.|...:|.||.|:||||:.:::|.|||:|.|..:|..|||.:||.:..|
Worm   564 ETGSGKTTQMTQYAIEAGLGRRGKIGCTQPRRVAAMSVAKRVAEEYGCKLGTDVGYTIRFEDCTS 628

  Fly   136 SCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSA 200
            ..|.||:||:|:||||.|.||.|:.|.:|::||||||.:.||::.||||...|||..|||||:||
Worm   629 QDTIIKYMTDGMLLRECLIDPDLSGYSLIMLDEAHERTIHTDVLFGLLKAAARKRPELKLIITSA 693

  Fly   201 TIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQKEPPGDIL 265
            |:|:..|||:|.     |..: .:|.||..||...|..||.:||::....||.::|..|||||:|
Worm   694 TLDSVKFSEYFL-----EAPI-FTIPGRTFPVEILYTREPESDYLEAAHITVMQIHLTEPPGDVL 752

  Fly   266 AFLTGQEEVLEALDLLREYIAS--SEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIA 328
            .|||||||:..:.::|.|.:.|  .:...|.:||:||::.|..|..:|...|.|.||||:|||||
Worm   753 VFLTGQEEIDTSCEVLYERMKSMGPDVPELIILPVYGALPSEMQTRIFDPAPAGKRKVVIATNIA 817

  Fly   329 ETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSD 393
            |||:||.||.||:|.|:||.|.||||:..||||:.|:|:|:|.||:|||||..|||.|||||:..
Worm   818 ETSLTIDGIFYVVDPGFVKQKIYNPKSGMDSLVVTPISQAAAKQRSGRAGRTGPGKCYRLYTERA 882

  Fly   394 Y-EALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGN 457
            : :.:.|...||::|:.|:..:|||||:||.|::.|||...||..::::||.:|..|.|:|..|.
Worm   883 FRDEMLPTPVPEIQRTNLASTLLQLKAMGINNLIDFDFMDAPPLDSMITALNTLHTLSALDGDGL 947

  Fly   458 LTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRK 522
            ||| :|..:||.|....|||:|.:|..:|||||::||:|:|.||:||.||..  .|........|
Worm   948 LTK-LGRRMAEFPLEPSLSKLLIMSVDLGCSEEVLTIVAMLNVQNIFYRPKE--KQDHADQKKAK 1009

  Fly   523 FEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIPIFSCKG 587
            |...|||.:|:|..|..:.....::.:|.:.|:..|::|||..:|:||:.: ..::.:.:.||..
Worm  1010 FHQPEGDHLTLLAVYNSWKNHHFSQPWCFENFIQVRSMKRAQDIRKQLLGI-MDRHKLLMVSCGR 1073

  Fly   588 DVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYGELLQTTKLFM 652
            ||.::.|.|.:|||...|.......||.::.|..:.|||:|..:. .|.::|||.||:.|||.:|
Worm  1074 DVSRVQKAICSGFFRNAAKRDPQEGYRTLTDGQNVYIHPSSACFQ-QQPEWVVYHELVMTTKEYM 1137

  Fly   653 NYVTVIKREWLTELAPHYYQ 672
            ..||.|..:||.|.||.:::
Worm  1138 REVTAIDPKWLVEFAPSFFK 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	280/630 (44%)
		DEXDc	64..202	CDD:238005	74/137 (54%)
		HELICc	289..380	CDD:197757	51/90 (57%)
		HA2	448..534	CDD:214852	38/85 (45%)
		OB_NTP_bind	<581..670	CDD:285018	35/88 (40%)
mog-5	NP_495019.1	S1_DHX8_helicase	234..311	CDD:240189
		DEXDc	534..721	CDD:214692	93/192 (48%)
		DEXDc	557..695	CDD:238005	74/137 (54%)
		HELICc	766..870	CDD:197757	55/103 (53%)
		HA2	939..1021	CDD:214852	38/84 (45%)
		OB_NTP_bind	1055..1154	CDD:285018	36/100 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730