DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and F52B5.3

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_492260.1	Gene:	F52B5.3 / 172615	WormBaseID:	WBGene00009922	Length:	1425	Species:	Caenorhabditis elegans

Alignment Length:	970	Identity:	225/970 - (23%)
Similarity:	361/970 - (37%)	Gaps:	349/970 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYL----YEWGWHTKGLIGITEP 100
            |.:.|..||..:|.||:|..:....|||:.|.||.||:|||||::    :|...|.:  :.:|:|
Worm   174 LQKVRNSLPASKYCDQVLKSISSCNVVIISGGTGCGKTTQVPQFILDEAHENNKHVR--VMVTQP 236

  Fly   101 RRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVII 165
            ||::.:::|.|||:||||.:|.||||.||.....|..|.:.:.|.|:|||.:.:||:.:....|:
Worm   237 RRIAAISIAERVARERGEPIGRTVGYQVRLDSRRSDDTVLTYCTTGVLLRMLTSDPVASGITHIV 301

  Fly   166 VDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDAS--FFSEFFSWPGSGEVSVKLSIEGR 228
            :||.|||.:.||.:|..|::.|:.|..||:|:.||||:.:  .||.:|.   :..:.| :.||.|
Worm   302 MDEIHEREINTDYLLIALRECLKMRPDLKVILMSATIEGNMQLFSNYFE---NHSMDV-IRIESR 362

  Fly   229 MHPVSNFYLNE------------------------------------------------------ 239
            ...|..|||::
Worm   363 AFDVKVFYLDQILAMTGYQPPESKAFFSTAEYEEEDWKDEIEAVEREEKDKAKQRAADSSLSTLS 427

  Fly   240 ------------------------PCA----DYVKE-------------------TVE------- 250
                                    ||:    |.:.|                   |||
Worm   428 KPVTKMAANTKRNSPIEEREWTSGPCSTPDGDIIDERAMRQYMNIIGNPDIRPVITVEFRPTTPN 492

  Fly   251 ---------------TVWKLHQ------------------------KEPP--------------- 261
                           :...|.|                        |.||
Worm   493 SVFINDVKYTTNPNQSAQALLQQKRERCLMPRGPLTFTCENPASTTKSPPSPTPTLGISSGLAKF 557

  Fly   262 ----------------------------------------------------------------- 261

Worm   558 TPFGGFGEKQRISTLLEKKFKEELKTALPDRTVYYHPQMNDVVDKTDFSKLRFGEKYNLFYGSSS 622

  Fly   262 ----------------------GDILAFLTGQEEV---LEALDLLREYIASSEQENLKVLPMYGS 301
                                  |.||.||.|.|::   |:|:|..:..:  ...:|:.|||::..
Worm   623 NNSVDYVLLDQVIQYLADSPVFGTILVFLPGYEDIQQMLKAIDCWKNSL--KNMKNVIVLPLHSQ 685

  Fly   302 MSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVS 366
            |:|.:...:|.:.||.|||::|||||||.||||..:::|:|.|.||.|.::.:....:|.:.|::
Worm   686 MTSINHGDIFKSVPKDTRKIILATNIAEASITIEDVIFVVDTGKVKEKSFDHEAKLSTLTVKPIA 750

  Fly   367 KASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDF- 430
            :::|.||:|||||:..|...||||:.:|.::...|..||:|:.:....|..|......:...:|
Worm   751 RSNADQRSGRAGRVANGYCIRLYTEQEYNSMPETQIAEMKRAAIYDVTLHAKLFAPKTLKISEFL 815

  Fly   431 ---PSPPPAQNLLSALESLFALDAI-------DEQGN--------------------LTKPVGYL 465
               |.||..:::|.|:..|..:.|.       |..||                    || .:|.|
Worm   816 SLAPEPPEKESILQAITFLEQIGAFYTPIKIYDNSGNEEGLKNDEEAENSENPEDPELT-DLGRL 879

  Fly   466 LAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAEGD- 529
            :|.||....||:||.....:.|...|:.::|||..:..:   ..|:::.....:..|||:|:.|
Worm   880 MARLPLDPQLSRMLLFGLALKCLTPIVNLVALLASREPY---VLALSEDRDLQSKMKFEMAQQDL 941

  Fly   530 -----FITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLI--TVARKKYGIPIFSCKG 587
                 :|.:.|.:.. .......:||..:||.:..::.....|.||:  .|..|...|   |...
Worm   942 SDHLLYIRLCNEFCS-KNNSQQNQFCRDHFLNFSTMRMVQGTRRQLLRELVRAKLINI---SPNR 1002

  Fly   588 DV---------EKLCKC-------ITAGFFTQVAYLHHSGVYRQISSGTE--LAIHPNSTL---- 630
            ||         .:..:|       |.||.:..:.........:::.:..:  ..:||:|.:
Worm  1003 DVLTVLTDHHFNQFSQCWPMIQAVIAAGCYPFIGVSASESNLKKVQTFNDKPAFLHPSSMVKKQI 1067

  Fly   631 ------YTLPQAQYVVYGELLQ---TTKLFMNYVTVIKREWLTEL---APHYYQQTTVRD 678
                  ...|:.:||.:.|:.|   ...|.|..||||..  :|.|   .|....:.|:.|
Worm  1068 VKMGKSEKSPRVEYVAFQEMCQMPSDRSLSMKTVTVIPS--MTALLFTGPIRLDERTIED 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	222/958 (23%)
		DEXDc	64..202	CDD:238005	60/141 (43%)
		HELICc	289..380	CDD:197757	38/90 (42%)
		HA2	448..534	CDD:214852	27/118 (23%)
		OB_NTP_bind	<581..670	CDD:285018	24/122 (20%)
F52B5.3	NP_492260.1	R3H	21..100	CDD:214647
		DEXDc	189..369	CDD:214692	72/185 (39%)
		DEXDc	198..338	CDD:238005	60/141 (43%)
		eIF3_subunit	393..>470	CDD:285763	4/76 (5%)
		Helicase_C	647..764	CDD:278689	47/118 (40%)
		HA2	869..948	CDD:214852	22/82 (27%)
		OB_NTP_bind	984..1116	CDD:285018	28/136 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810