DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and let-355

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_491604.3	Gene:	let-355 / 172199	WormBaseID:	WBGene00020263	Length:	856	Species:	Caenorhabditis elegans

Alignment Length:	750	Identity:	257/750 - (34%)
Similarity:	374/750 - (49%)	Gaps:	95/750 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTFKPKFLKPETDDAI-----------TDSAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRD 54
            :||..||.| |:|..:.           |......|||... |..|:.   ...|.:|||.....
Worm   109 ISTQTPKKL-PKTPISTPSNSKNATPMSTRKHSSSQQSPPH-FEANYE---KFSRPQLPIDAVEQ 168

  Fly    55 QILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVSTVTLANRVAQERGEL 119
            |::|.|...:.:|::|||||||||||||.....|....|.|.:|:||||:.::||:|||.|.|..
Worm   169 QLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVATEMGTN 233

  Fly   120 VGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLK 184
            :|..|||.|||..:....|||::||:||:||:.|..|||.:|..:|:||||||::.:|:::.:|:
Worm   234 IGGIVGYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILR 298

  Fly   185 KILRKR----SSLKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNE------ 239
            :...:|    :.|:|||.|||:.|..|..:|:     ...|.| :.||..|:..|::|.
Worm   299 QCQDQRRETNNPLRLIIMSATLQAEKFQSYFN-----NAKVVL-VAGRTFPIEVFHVNPKINKSF 357

  Fly   240 PCADYVKETVETVWKLHQKEPPG-DILAFLTGQEEVLEALDLLREYIAS--SEQENLKVLPMYGS 301
            ...|||...|..|..:|..||.| |||.||||.||:......|.|...|  :..:.|..:|:|.:
Worm   358 SSTDYVYNAVICVKYVHLTEPKGRDILVFLTGSEEIEAVASQLAELNGSLPASADVLMPVPLYAA 422

  Fly   302 MSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVS 366
            :....|...|...|:|.|||:::|||||||:|||||..|||.|.||.|.:......|.|.:..||
Worm   423 LRPEKQKEAFRKTPQGARKVIISTNIAETSVTIPGIRVVIDSGKVKTKRFEAFNRIDVLKVHNVS 487

  Fly   367 KASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFP 431
            ||.|.||||||||..|||.||||::.|:........||:.|..||...|:|..||:.|..|....
Worm   488 KAQAKQRAGRAGRDAPGKCYRLYSREDFHKFEAENMPEILRCNLSATFLELMKLGMKNPHRLKLI 552

  Fly   432 SPPPAQNLLSALESLFALDAIDEQGNLTKPVG-----YLLAEL-------PFSAMLSKMLYVSGQ 484
            .||...|:.:||..|.:|.||       :||.     :.|.|:       |.....:::|:.:.:
Worm   553 DPPETDNINAALLELTSLGAI-------RPVNSDRSKFALTEMGDAFCMYPLPPDHARILFQAQK 610

  Fly   485 MGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAEGDFITML--------------- 534
            .||..|.|.|:|.:|..::||....:.:........|:||..|||.||:|
Worm   611 EGCIMEAIKIVAAMQTDALFSGAGDSKSDADVDRIRRRFETREGDHITLLKLVLVTNQFFDQLNK 675

  Fly   535 ----NAYTGFVEEGMTKE-------FCGQYFLIYRNLKRAHSLREQL--ITVARKKYGIPIFSCK 586
                :|..|...:.:.:|       ||....:..::||.|..:.|||  |.:.:|   :...:|.
Worm   676 KTESDARYGKANKSLEREYNQTIRKFCNDNMINEQHLKTASMIEEQLKQIAIEQK---VTFSTCG 737

  Fly   587 GDVEKLCKCITAG-FFTQVAYLHHSGVYR-QISSGTELAIHPNSTLYTLPQAQYVVYGELLQTTK 649
            .|..|:.|.:..| |.....|......|| .|:....|.|||:|.| :..:..|:|:.||::|..
Worm   738 ADFMKMRKALALGMFLNSCEYDRQEDRYRLMINPAITLKIHPSSCL-SRSKPAYIVFSELMKTND 801

  Fly   650 LFMNYVTVIKREWL-------TELAPHYYQQTTVR 677
            ||...||:|..:|:       .::..::..:||.|
Worm   802 LFALQVTLIDGDWVRPLISDHKKMRANHLAETTER 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	241/689 (35%)
		DEXDc	64..202	CDD:238005	66/141 (47%)
		HELICc	289..380	CDD:197757	43/90 (48%)
		HA2	448..534	CDD:214852	26/97 (27%)
		OB_NTP_bind	<581..670	CDD:285018	27/97 (28%)
let-355	NP_491604.3	HrpA	149..>800	CDD:224557	236/670 (35%)
		DEXDc	180..320	CDD:238005	66/139 (47%)
		Helicase_C	383..500	CDD:278689	53/116 (46%)
		HA2	569..660	CDD:214852	26/97 (27%)
		OB_NTP_bind	712..822	CDD:285018	35/113 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830