DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3225 and DHX36

DIOPT Version :9

Sequence 1:NP_608860.1 Gene:CG3225 / 33680 FlyBaseID:FBgn0031631 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_065916.2 Gene:DHX36 / 170506 HGNCID:14410 Length:1008 Species:Homo sapiens


Alignment Length:764 Identity:222/764 - (29%)
Similarity:360/764 - (47%) Gaps:140/764 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 QSSAFVFNVNHNMGLMEQ---------------------RERLPIRQYRDQILYCLEKHQVVILV 69
            :.|.::...|...|.::|                     ||:||....:.:::..::.|||.::.
Human   165 RDSEYLLQENEPDGTLDQKLLEDLQKKKNDLRYIEMQHFREKLPSYGMQKELVNLIDNHQVTVIS 229

  Fly    70 GETGSGKSTQVPQYL----YEWGWHTKGLIGITEPRRVSTVTLANRVAQERGELV--GDTVGYVV 128
            ||||.||:|||.|::    .|.|..:...|..|:|||:|.:::|.|||.||.|..  |::.||.:
Human   230 GETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGSGNSTGYQI 294

  Fly   129 RFLESM-SSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSS 192
            |....: .....|.:.|.||:|:.:.:||.|:....|::||.||||:.:|:::.::|.:|..||.
Human   295 RLQSRLPRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSD 359

  Fly   193 LKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYL-------------------- 237
            ||:|:.|||::|..|||:|     |...: :.|.|...||..:.|                    
Human   360 LKVILMSATLNAEKFSEYF-----GNCPM-IHIPGFTFPVVEYLLEDVIEKIRYVPEQKEHRSQF 418

  Fly   238 ---------------------NEPCADYVKE--------TVETVWKLHQ---------------- 257
                                 .|...|||:|        ||:.:..:..                
Human   419 KRGFMQGHVNRQEKEEKEAIYKERWPDYVRELRRRYSASTVDVIEMMEDDKVDLNLIVALIRYIV 483

  Fly   258 -KEPPGDILAFLTGQEEVLEALDLLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKV 321
             :|..|.||.||.|.:.:....|||...:.....:.| ::|::..|.:.:|..||...|.|.||:
Human   484 LEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDKFL-IIPLHSLMPTVNQTQVFKRTPPGVRKI 547

  Fly   322 VLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVY 386
            |:|||||||||||..:|||||.|.:|...::.:....::....||||:|.||.|||||::||..|
Human   548 VIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCY 612

  Fly   387 RLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRF--DFPSPPPAQNLLSALESLFAL 449
            .||.......|...|.||:.|:.|....||:|.|.:|.|..|  ....||..:.:|.::..|..|
Human   613 HLYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSNEAVLLSIRHLMEL 677

  Fly   450 DAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQ 514
            :|:|:|..|| |:|..||.||....:.||:.......|.:.::||.|.|..:..|..|   :.::
Human   678 NALDKQEELT-PLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIP---LGKE 738

  Fly   515 SGRIAHRKFEVAE---GDFITMLNAYTGFVE---EGM--TKEFCGQYFLIYRNLKRAHSLREQLI 571
            ....|.|| |:|:   .|.:|::||:.|:.|   .|.  .|::|.:|||....|:..|:::.|..
Human   739 KIADARRK-ELAKDTRSDHLTVVNAFEGWEEARRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFA 802

  Fly   572 T-------VARKKYGIPIFSCKGDVEKLCKC-ITAGFFTQVAYLH-HSGVYR---QISSGTE--L 622
            .       |:.:....|..:...|.||:.|. |.||.:.:||.:. :.|..|   ::.:.|:  :
Human   803 EHLLGAGFVSSRNPKDPESNINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVYTKTDGLV 867

  Fly   623 AIHPNSTLYTLPQAQY--VVYGELLQTTKLFMNYVTVIKREWLTELAPH 669
            |:||.|.........|  ::|...::|:.:::..        .||::|:
Human   868 AVHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYD--------CTEVSPY 908

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3225NP_608860.1 HrpA 40..668 CDD:224557 218/747 (29%)
DEXDc 64..202 CDD:238005 56/144 (39%)
HELICc 289..380 CDD:197757 40/90 (44%)
HA2 448..534 CDD:214852 28/88 (32%)
OB_NTP_bind <581..670 CDD:285018 23/98 (23%)
DHX36NP_065916.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000269|PubMed:18279852 1..200 4/34 (12%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..104
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000269|PubMed:18854321 1..51
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:24151078 53..105
DSM (DHX36-specific motif). /evidence=ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26649896 53..75
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 106..386 72/226 (32%)
DEXDc 210..392 CDD:214692 66/187 (35%)
DEXDc 224..369 CDD:238005 56/144 (39%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 265..317 18/51 (35%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 334..337 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 387..628 68/241 (28%)
Helicase_C 476..606 CDD:278689 50/130 (38%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 498..557 20/59 (34%)
Nuclear localization signal. /evidence=ECO:0000303|PubMed:14731398 517..528 2/11 (18%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 629..698 26/69 (38%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 638..697 21/59 (36%)
HA2 676..760 CDD:214852 28/88 (32%)
OB_NTP_bind 800..917 CDD:285018 25/117 (21%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 841..905 13/71 (18%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 849..860 2/10 (20%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 870..900 6/29 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53574
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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