DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3225 and Dhx9

DIOPT Version :10

Sequence 1:NP_608860.1 Gene:CG3225 / 33680 FlyBaseID:FBgn0031631 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_001392438.1 Gene:Dhx9 / 13211 MGIID:108177 Length:1384 Species:Mus musculus


Alignment Length:725 Identity:213/725 - (29%)
Similarity:335/725 - (46%) Gaps:138/725 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 NHNM-GLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQY-LYEWGWHTKGL--- 94
            :||: .::::||.||::::..:||..:..:.|||:.|.||.||:|||||| |.::..:.:..   
Mouse   378 DHNLQSVLQERELLPVKKFEAEILEAISSNSVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECN 442

  Fly    95 IGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESM--SSCTKIKFMTEGILLREVLADPL 157
            |.:|:|||:|.|.:|.|||.||||..|.:.||.||| ||:  .....|.|.|.|:|||::.|   
Mouse   443 IVVTQPRRISAVAVAERVAYERGEEPGKSCGYSVRF-ESILPRPHASIMFCTVGVLLRKLEA--- 503

  Fly   158 LTQYGV-----IIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSE-FFSWPGS 216
                |:     :||||.|||::.||.:|.:|:.::.....:::::.|||||.:.|.| ||:.|  
Mouse   504 ----GIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSATIDTTMFCEYFFNCP-- 562

  Fly   217 GEVSVKLSIEGRMHPVSNFYL---------------------------------NEPCAD-YVKE 247
                 .:.:.||..||..::|                                 |..|.| |..|
Mouse   563 -----IIEVYGRTFPVQEYFLEDCIQMTQFIPPPKDKKKKDKEDDGGEDDDANCNLICGDEYGPE 622

  Fly   248 TVETVWKLHQKEP-----------------PGDILAFLTGQEEVLEALDLLREYIASSEQEN--- 292
            |..::.:|::||.                 ||.:|.||.|...:         |......||   
Mouse   623 TKLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLI---------YTMQKHLENNSH 678

  Fly   293 -----LKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYN 352
                 .::||::..:...:|..||...|.|..||:|:||||||||||..:|||||....|||.:.
Mouse   679 FGSHRYQILPLHSQIPREEQRKVFDPVPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFT 743

  Fly   353 PKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQL 417
            ......:...|..||.:..||.|||||:|||..:.|.:::.::.|.....|||.|:.|....|.:
Mouse   744 AHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFDRLETHMTPEMFRTPLHEIALSI 808

  Fly   418 KALGIGNILRF--DFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLY 480
            |.|.:|.|.:|  ....|||...::.|..:|..|||:|....|| |:|.:||:||......||:.
Mouse   809 KLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELT-PLGRILAKLPIEPRFGKMMI 872

  Fly   481 VSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAE-GDFITMLNAYTGFVEEG 544
                |||...:...:..:...:.|..|..:..::.|.| ||.|.... .|.:.:|:.:..:.:..
Mouse   873 ----MGCIFYVGDAVCTISAATCFPEPFISEGKRLGYI-HRNFAGNRFSDHVALLSVFQAWDDAR 932

  Fly   545 MTKE-----FCGQYFLIYRNLKRAHSLREQLITVARKKYGIP-------IFSCKG---DVEKLCK 594
            |:.|     ||.|..|....|:.....:.||..:.... |.|       :|:..|   :::.:..
Mouse   933 MSGEEAEIRFCEQKRLNMATLRMTWEAKVQLKEILINS-GFPEDCLLTQVFTNTGPDNNLDVVIS 996

  Fly   595 CITAGFFTQVAYLHHSGVYRQI--SSGTELAIHPNST---------LYTLPQAQYVVYGELLQTT 648
            .:..|.:..|.|....   |:|  :.|....||.:|.         .|..|   :.|:||.::|.
Mouse   997 LLAFGVYPNVCYHKEK---RKILTTEGRNALIHKSSVNCPFSSQDMKYPSP---FFVFGEKIRTR 1055

  Fly   649 KLFMNYVTVI 658
            .:....:|::
Mouse  1056 AISAKGMTLV 1065

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3225NP_608860.1 HrpA 38..>669 CDD:441249 211/722 (29%)
Dhx9NP_001392438.1 DSRM_DHX9_rpt1 3..71 CDD:380683
siRNA-binding. /evidence=ECO:0000250|UniProtKB:Q08211 5..9
siRNA-binding. /evidence=ECO:0000250|UniProtKB:Q08211 53..55
DSRM_DHX9_rpt2 181..255 CDD:380684
siRNA-binding. /evidence=ECO:0000250|UniProtKB:Q08211 185..189
Interaction with BRCA1. /evidence=ECO:0000250|UniProtKB:Q08211 233..328
siRNA-binding. /evidence=ECO:0000250|UniProtKB:Q08211 237..239
Necessary for interaction with RNA polymerase II holoenzyme. /evidence=ECO:0000250|UniProtKB:Q08211 258..667 96/312 (31%)
Necessary for interaction with H2AX. /evidence=ECO:0000250|UniProtKB:Q08211 316..955 191/606 (32%)
DEXHc_DHX9 333..566 CDD:350730 76/202 (38%)
MTAD. /evidence=ECO:0000250|UniProtKB:Q08211 334..383 2/4 (50%)
HrpA 391..>889 CDD:441249 171/526 (33%)
Core helicase. /evidence=ECO:0000250|UniProtKB:Q08211 401..812 142/434 (33%)
DEAH box 514..517 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 589..611 0/21 (0%)
Nuclear localization signal (NLS1). /evidence=ECO:0000255 589..598 0/8 (0%)
HA2. /evidence=ECO:0000250|UniProtKB:Q08211 834..922 27/93 (29%)
OB-fold. /evidence=ECO:0000250|UniProtKB:Q08211 961..1077 22/112 (20%)
OB_NTP_bind 997..1076 CDD:400182 16/75 (21%)
Nuclear localization signal (NLS2). /evidence=ECO:0000250|UniProtKB:Q08211 1158..1176
Blue background indicates that the domain is not in the aligned region.

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