DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3225 and dhx37

DIOPT Version :9

Sequence 1:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_005172500.1	Gene:	dhx37 / 100009635	ZFINID:	ZDB-GENE-030131-4505	Length:	1153	Species:	Danio rerio

Alignment Length:	772	Identity:	254/772 - (32%)
Similarity:	384/772 - (49%)	Gaps:	154/772 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTK-GLIGITEPRRV 103
            :.|.|.|||:......|:..::.|:.|:|.|||||||:|||||:|||.|:.:. |:||:||||||
Zfish   246 IQEARLRLPVLAEEQIIMEAVKDHECVVLCGETGSGKTTQVPQFLYEAGFASSGGIIGVTEPRRV 310

  Fly   104 STVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDE 168
            :.:::::|||.|. .|....|.|.:|:..:::..||||.||:|:||:|:..|.||.:|.|||:||
Zfish   311 AAISMSHRVATEM-NLSSGVVSYQIRYEGNVTENTKIKVMTDGVLLKEIQRDFLLQKYSVIIIDE 374

  Fly   169 AHERNMLTDMILGLLKKI--LRKRSSL--KLIISSATIDASFFSE---FFSWPGSGEVSVKLSIE 226
            ||||::.||:::|||.:|  ||.:..|  ||||.|||:....|:|   .||.|     ...:.:|
Zfish   375 AHERSVYTDILIGLLSRIVPLRNKKGLPMKLIIMSATLRVEDFTENKRLFSSP-----PPVIKVE 434

  Fly   227 GRMHPVS-NFYLNEPCADYVKETVETVWKLHQKEPPGDILAFLTGQEEVLEALDLLRE---YIAS 287
            .|...|: :|....|..||..||...:.|:|:..|||.||.|||||.||......||:   |..:
Zfish   435 ARQFAVTVHFNKRTPMDDYTGETFRKICKIHRMLPPGGILVFLTGQAEVHSVCRRLRKAFPYKPN 499

  Fly   288 SE-------QENLK--------------------------------------------------- 294
            .|       :|:||
Zfish   500 REHTDMMETEEDLKKSKRAKKKNVSLPRINLDNYSALPVDEGDEDRQAGIDEDDGEGSDLELELG 564

  Fly   295 ------------------VLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVI 341
                              |||:|..::...|..||..||.|:|..|:|||:||||:|||||.||:
Zfish   565 DHPDTDHEEKADPSIPLYVLPLYSLLAPEQQAKVFRPPPAGSRLCVVATNVAETSLTIPGIKYVV 629

  Fly   342 DCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMR 406
            |||.||.::|:..|...|..:..:|:|||.||||||||..||..||||:.:.:...:.....|:.
Zfish   630 DCGRVKKRFYDRVTGVSSFKVTWISQASANQRAGRAGRTEPGHCYRLYSSAVFGDFSLFSEAEIT 694

  Fly   407 RSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDE---QGNLTK-------- 460
            |..:...:||:|.|.|..::.|.||:||.::.|::|.|.|.:|.|:::   .|.|::
Zfish   695 RRPVEDLVLQMKDLNIEKVVNFPFPTPPSSEALIAAEELLISLGALEKPARHGRLSEMEKARLSC 759

  Fly   461 ---PVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIF---SRPASAV---AQQSG 516
               |:|..:|..|.:...:|||.:..|.||.:.||||::.:.|:.||   .|||.:.   .:.||
Zfish   760 PISPLGRAMAAFPVAPRYAKMLALGRQQGCMQYIITIVSAMTVREIFEDYDRPAGSEEENVKMSG 824

  Fly   517 RIAH----RKFEVAE------GDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLI 571
            :.|.    |:....:      ||.:.:|.|.......|:|.:||.:..|.::.:.....||.||.
Zfish   825 KKARSVQMRRLWAGQGASLLLGDLMVLLGAVGACEFAGLTPQFCEENGLRFKAMLEIRRLRGQLT 889

  Fly   572 TVAR-----------KKYGIPIFSCKGDVEKLC--KCITAGFFTQVAYLHHS---------GVYR 614
            ....           .|...|.     :.:.||  :.:.||....:|....:         ..|:
Zfish   890 NAVNAVCADADVYVDNKMAPPT-----EAQVLCLRQIVLAGLGDHIARRVQAEELLDPKWRNAYK 949

  Fly   615 QISSGTELAIHPNSTLY-TLPQAQYVVYGELLQTTKLFMNYVTVIKREWLTELAPHY 670
            .......:.|||:|.|: |||  ::|||.|:::|||::|..|..::.:|:.:|.|.|
Zfish   950 TPLLDDPVFIHPSSALHKTLP--EFVVYQEIMETTKMYMRGVCAVQDDWIPKLLPQY 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	252/768 (33%)
		DEXDc	64..202	CDD:238005	73/142 (51%)
		HELICc	289..380	CDD:197757	49/166 (30%)
		HA2	448..534	CDD:214852	30/115 (26%)
		OB_NTP_bind	<581..670	CDD:285018	27/100 (27%)
dhx37	XP_005172500.1	HrpA	200..1007	CDD:224557	254/772 (33%)
		DEXDc	272..412	CDD:238005	73/140 (52%)
		HELICc	583..667	CDD:197757	44/83 (53%)
		HA2	730..781	CDD:282288	12/50 (24%)
		HA2	761..>813	CDD:214852	18/51 (35%)
		OB_NTP_bind	<918..1004	CDD:285018	24/87 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820