DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fipi and KIRREL3

DIOPT Version :9

Sequence 1:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	313	Identity:	80/313 - (25%)
Similarity:	134/313 - (42%)	Gaps:	54/313 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SLSLSP---AEHSVVRYTNESLIVQCRS-PDPKVELHWKSPKGEIIREHKGRIHIEQTSTEQLKI 84
            :||:.|   .|.:||.:       .|.: .:|.|..:..:.:|:||:|..|.::  :|:.:.  .
Human   259 NLSVEPQPVLEDNVVTF-------HCSAKANPAVTQYRWAKRGQIIKEASGEVY--RTTVDY--T 312

  Fly    85 VFAHIALADKGNWSCEAAD--GSLH-SKSFDLIVYQKITFTENATVMTVKEGEKATILCEVKGEP 146
            .|:...       |||..:  ||.: |::.|:....::| ||..::: |..|..|...|...|.|
Human   313 YFSEPV-------SCEVTNALGSTNLSRTVDVYFGPRMT-TEPQSLL-VDLGSDAIFSCAWTGNP 368

  Fly   147 QPNVTWHFNGQPISAGAADDSKFRILAD--GLLINKVTQNDTGEYACRAYQVNSIASDMQERTVL 209
            ...:.|...|..:           :|::  .|.:..|.|.|.|:|.|||. |..:.:.  ||.|.
Human   369 SLTIVWMKRGSGV-----------VLSNEKTLTLKSVRQEDAGKYVCRAV-VPRVGAG--EREVT 419

  Fly   210 MKIEHKPIWSKTPFVSLKYAYINGTATLMCEALAEPPAN-FTWYRKHNKLHS-NNRLYTIQS--- 269
            :.:...||.|.|   ..::|.......:.|...:.||.: ..|..|.|.|.| .:..||:::
Human   420 LTVNGPPIISST---QTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETIST 481

  Fly   270 -DSYWSSLTIHVLNTSAFDN-YRCRARNDLGTIERTTRL-EQGEKPPSPANFQ 319
             :...|:|||..:..:.|.. |.|.|.|..|:.....|| |||.:..|.|..:
Human   482 EEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fipi	NP_787975.1	IG_like	33..115	CDD:214653	19/85 (22%)
		I-set	128..202	CDD:254352	19/75 (25%)
		Ig	133..>193	CDD:299845	15/61 (25%)
		IG_like	228..307	CDD:214653	23/86 (27%)
		Ig	235..305	CDD:143165	20/76 (26%)
		FN3	312..415	CDD:238020	2/8 (25%)
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845
		IG_like	60..149	CDD:214653
		I-set	156..249	CDD:254352
		Ig2_KIRREL3-like	171..252	CDD:143236
		Ig_2	260..337	CDD:290606	22/94 (23%)
		I-set	341..422	CDD:254352	25/96 (26%)
		IGc2	355..406	CDD:197706	15/61 (25%)
		Ig5_KIRREL3	424..521	CDD:143306	26/99 (26%)
		IG_like	432..521	CDD:214653	22/88 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900